Toxicology_ Pathophysiology.pdf
Toxicology: Pathophysiology
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Guide, Practice Questions,
Answers & ATI Review
Material
, Toxicology: Pathophysiology
Toxicology Pathophysiology.pdf
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1. describes the changes that occur during a dis- what is pathophysiology?
ease process, with "patho-" referring to the physical
changes that are observed and "physio-" referring to
the functional processes or mechanisms that occur
during a disease process
2. pathophysiology encompasses the biochemical and what does pathophysiolo-
physical alterations that occur upon exposure of an gy include in toxicology
individual (generally termed the "host") to harmful
amounts of a toxicant.
3. In toxicology, pathophysiology takes into account describe the pictured rela-
how the characteristics of the toxicant (for exam- tionship
ple, dosage, physical properties and chemical prop-
erties) and the characteristics of the host (including
species, life stage, health/reproductive status, metab-
olism, and individual sensitivity) interact to produce
physical and/or biochemical changes in the host
4. rapid death With acutely lethal intox-
ications, the physical and
chemical injury may be suf-
ficient to cause ___ ____
of the organism
5. toxicant-induced injury results in dysfunction of cells, what are non-lethal toxic
tissues and/or organs that may persist or that may exposures?
progress to death.
6. does not result in death generally leads to attempts at what is persistant toxic in-
repair of toxicant-induced damage jury?
7. true
, Toxicology: Pathophysiology
Toxicology Pathophysiology.pdf
Study online at https://quizlet.com/_hpulhg
TRUE/FALSE: With some
toxicants, the host is able
to develop strategies to
adapt to continued expo-
sure to toxicants.
8. Dysfunction, repair and adaptive processes that occur define carcinogenesis
in response to exposure to certain toxicants may trig-
ger development of unregulated cell growth leading to
tumor formation
9. an result in physical and biochemical alterations that what can toxic insults re-
may lead to cellular dysfunction, repair, adaptation, sult in?
carcinogenesis and/or death.
10. The clinical syndrome associated with a poisoning what is toxicosis?
11. Covalent binding forms practically irreversible bonds what is an adduct?
between the toxicant and target molecule; the result-
ing toxicant-target molecule is termed an adduct.
12. The acetaminophen metabolite NAPQI is normally
detoxified through binding with glutathione. If glu-
tathione becomes depleted, NAPQI can then bind
to cellular macromolecules, resulting in cell injury.
Providing the glutathione precursor n-acetylcysteine
helps to replenish glutathione stores and mitigate
NAPQI-induced injury to cellular structures
13. Step 1. Electron transfer
Step 2. Lipid peroxidation
Toxicology: Pathophysiology
| Complete Exam Study
Guide, Practice Questions,
Answers & ATI Review
Material
, Toxicology: Pathophysiology
Toxicology Pathophysiology.pdf
Study online at https://quizlet.com/_hpulhg
1. describes the changes that occur during a dis- what is pathophysiology?
ease process, with "patho-" referring to the physical
changes that are observed and "physio-" referring to
the functional processes or mechanisms that occur
during a disease process
2. pathophysiology encompasses the biochemical and what does pathophysiolo-
physical alterations that occur upon exposure of an gy include in toxicology
individual (generally termed the "host") to harmful
amounts of a toxicant.
3. In toxicology, pathophysiology takes into account describe the pictured rela-
how the characteristics of the toxicant (for exam- tionship
ple, dosage, physical properties and chemical prop-
erties) and the characteristics of the host (including
species, life stage, health/reproductive status, metab-
olism, and individual sensitivity) interact to produce
physical and/or biochemical changes in the host
4. rapid death With acutely lethal intox-
ications, the physical and
chemical injury may be suf-
ficient to cause ___ ____
of the organism
5. toxicant-induced injury results in dysfunction of cells, what are non-lethal toxic
tissues and/or organs that may persist or that may exposures?
progress to death.
6. does not result in death generally leads to attempts at what is persistant toxic in-
repair of toxicant-induced damage jury?
7. true
, Toxicology: Pathophysiology
Toxicology Pathophysiology.pdf
Study online at https://quizlet.com/_hpulhg
TRUE/FALSE: With some
toxicants, the host is able
to develop strategies to
adapt to continued expo-
sure to toxicants.
8. Dysfunction, repair and adaptive processes that occur define carcinogenesis
in response to exposure to certain toxicants may trig-
ger development of unregulated cell growth leading to
tumor formation
9. an result in physical and biochemical alterations that what can toxic insults re-
may lead to cellular dysfunction, repair, adaptation, sult in?
carcinogenesis and/or death.
10. The clinical syndrome associated with a poisoning what is toxicosis?
11. Covalent binding forms practically irreversible bonds what is an adduct?
between the toxicant and target molecule; the result-
ing toxicant-target molecule is termed an adduct.
12. The acetaminophen metabolite NAPQI is normally
detoxified through binding with glutathione. If glu-
tathione becomes depleted, NAPQI can then bind
to cellular macromolecules, resulting in cell injury.
Providing the glutathione precursor n-acetylcysteine
helps to replenish glutathione stores and mitigate
NAPQI-induced injury to cellular structures
13. Step 1. Electron transfer
Step 2. Lipid peroxidation
