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, Pathophysiology Mod 3 quiz
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1. What is innate Innate immunity, also called natural immunity, is the first line of defense. This type
immunity? of defense is in place before an infection takes place and can function immediately.
It is comprised of physical, chemical, cellular, and molecular defenses.
2. How does the The skin's design makes it a strong physical barrier. It has closely packed cells in
skin act as a phys- multiple layers that are continuously being shed. Keratin covers the skin, which
ical barrier? creates a salty, acidic environment inhospitable to microbes. It also contains an-
timicrobial proteins and lysozymes that inhibit microorganisms and help to destroy
them.
3. What cells are in- The cells responsible for this response include neutrophils, macrophages, dendrit-
volved in innate ic cells (DC), natural killer (NK) cells, and intraepithelial lymphocytes.
immunity?
4. Describe each Neutrophils are the most abundant in the body and are an early responder in
type of leukocyte innate immunity and use phagocytosis to kill microbes. Eosinophils are active
and explain their in parasitic infections and allergic responses. Basophils release histamine and
function: proteolytic enzymes. Monocytes are the largest in size and are released from
the bone marrow and mature into macrophages and dendritic cells where they
engage in the inflammatory response and phagocytize foreign substances and
cellular debris. Macrophages have a long life span, reside in the tissues, and are
the first phagocyte that organisms encounter. Neutrophils and macrophages work
together on behalf of the host's initial defense system.
5. Describe adap- Adaptive immunity, also called acquired immunity, is the second line of defense
tive immunity: and includes both humoral and cellular mechanisms that respond to cell-specific
substances known as antigens. Adaptive immunity is acquired through previous
exposure to infections and other foreign agents. It can not only distinguish self
from nonself but can recognize and destroy specific foreign agents based on their
different antigenic properties. This response takes more time but is extremely
effective.
6.
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