Pathophysiology (ATI)
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1. Change position slowly to prevent orthostatic hypotension. (Levodopa/carbidopa
can cause orthostatic hypotension.)
2. Phenytoin toxicity (Valproic acid can cause an increase in phenytoin blood levels,
resulting in phenytoin toxicity. The nurse should monitor serum phenytoin levels
and notify the provider if levels begin to exceed the therapeutic range.)
3. Avoid driving until the drug's effects are evident. (Baclofen, a centrally-acting
muscle relaxant, causes CNS depression. Clients taking the drug should avoid
alcohol and other CNS depressants, and should not drive a vehicle until they know
how the drug will affect them.)
4. Take the drug in the morning. (Modafinil is a nonamphetamine stimulant. Taking it
in the morning helps improve wakefulness for clients who have narcolepsy. Clients
taking the drug for shift-work sleepiness should take it 1 hr before work.)
5. "Administer the drug in your thigh or upper arm." (Interferon beta-1a is admin-
istered via the subcutaneous route. Therefore, the nurse should instruct the client
how to perform subcutaneous injections for self-administration.)
6. Jaundice (Valproic acid can cause hepatic toxicity, characterized by jaundice, ab-
dominal pain, and nausea. Clients taking the drug should report these manifesta-
tions, and the nurse should monitor liver function studies prior to treatment and
periodically during therapy.)
7. Tachycardia (Amphetamine sulfate is an amphetamine stimulant. It can cause
tachycardia and dysrhythmias. The client should notify the nurse if they develop
palpitations or chest pain.)
8. Muscle rigidity (A drug interaction between selegiline and opioids, especially
meperidine, can result in rigidity, stupor, agitation, hypertension, and fever.)
9.
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