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NURS 280 Exam 2 ATI Study Guide | 180+ Practice Questions & Verified Answers | Stress, Mental Health, Pain Management, Peripheral Vascular Disorders, Autoimmune Diseases & Gastrointestinal Nursing | 2026

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Prepare for NURS 280 Exam 2 with this comprehensive ATI study guide featuring 180+ expertly organized practice questions and verified answers covering the essential concepts of mental health nursing, stress and coping, pain management, peripheral vascular disorders, neurological disorders, gastrointestinal diseases, musculoskeletal disorders, dermatological conditions, and autoimmune diseases. This resource provides an in-depth review of stress adaptation, therapeutic communication, major depressive disorder (MDD), postpartum mood disorders, substance use disorders, pain assessment, opioid therapy, multiple sclerosis (MS), peripheral arterial disease (PAD), chronic venous insufficiency (CVI), deep vein thrombosis (DVT), Crohn's disease, ulcerative colitis, osteoarthritis, rheumatoid arthritis, psoriasis, contact dermatitis, and evidence-based nursing interventions. The material is presented in a structured question-and-answer format that promotes active recall, strengthens clinical reasoning, and prepares nursing students for ATI assessments, quizzes, unit exams, comprehensive examinations, and NCLEX-style testing. This study guide systematically explains the principles of stress physiology, coping mechanisms, and mental health nursing, including the General Adaptation Syndrome (GAS), acute and chronic stress responses, distress, therapeutic communication, cognitive reframing, assertive communication, coping strategies, role conflict, family coping, major depressive disorder (MDD), persistent depressive disorder, postpartum blues, postpartum depression, postpartum psychosis, suicide risk assessment, substance use disorders, alcohol withdrawal, benzodiazepine withdrawal, relapse prevention, disulfiram therapy, and recovery-focused nursing interventions. Students will also review psychiatric nursing concepts involving attention-deficit/hyperactivity disorder (ADHD), post-traumatic stress disorder (PTSD), childhood depression, failure to thrive, grief, loss, and patient-centered therapeutic communication. The guide also provides extensive coverage of pain management, neurological disorders, and peripheral vascular disease, including comprehensive pain assessment, acute versus chronic pain, opioid analgesics, patient-controlled analgesia (PCA), breakthrough pain, ketorolac, morphine, opioid adverse effects, multiple sclerosis (MS), neurological assessment, baclofen therapy, chronic venous insufficiency (CVI), peripheral arterial disease (PAD), arterial insufficiency, deep vein thrombosis (DVT), anticoagulant therapy, clopidogrel, heparin-to-warfarin bridging, compression therapy, and evidence-based vascular nursing care. Students will strengthen their understanding of medication safety, vascular assessment, diagnostic testing, and priority nursing interventions frequently tested on ATI and NCLEX examinations. Additionally, this resource thoroughly reviews gastrointestinal, musculoskeletal, dermatological, and autoimmune disorders, including Crohn's disease, ulcerative colitis, inflammatory bowel disease (IBD), corticosteroid therapy, sulfasalazine, nutritional management, osteoarthritis, rheumatoid arthritis, psoriasis, photochemotherapy (PUVA), calcipotriene therapy, contact dermatitis, diphenhydramine, back injury management, exercise recommendations, inflammatory laboratory findings, autoimmune disease assessment, and evidence-based nursing interventions. Organized into concise, exam-focused questions and verified answers, this study guide serves as an excellent revision resource for mastering the ATI concepts most frequently assessed in undergraduate nursing courses and NCLEX preparation. The content aligns with ATI nursing standards and the foundational principles presented in leading medical-surgical nursing, psychiatric nursing, pathophysiology, and adult health nursing textbooks widely adopted in undergraduate BSN and ADN nursing programs. Relevant Students: NURS 280 students, ATI Nursing students, Medical-Surgical Nursing students, Adult Health Nursing students, Mental Health Nursing students, Psychiatric Nursing students, Pathophysiology students, BSN students, ADN students, Registered Nursing students, Practical Nursing students, Pre-Licensure Nursing students, NCLEX-RN candidates, Health Sciences students, Nursing Exam Preparation students. APA References: Assessment Technologies Institute. (2023). RN Adult Medical Surgical Nursing Review Module (12th ed.). ATI Nursing Education. Assessment Technologies Institute. (2023). RN Mental Health Nursing Review Module (12th ed.). ATI Nursing Education. Harding, M. M., Kwong, J., Roberts, D., Hagler, D., & Reinisch, C. (2023). Lewis's Medical-Surgical Nursing: Assessment and Management of Clinical Problems (12th ed.). Elsevier. Ignatavicius, D. D., Workman, M. L., Rebar, C. R., & Heimgartner, N. M. (2024). Medical-Surgical Nursing: Concepts for Interprofessional Collaborative Care (11th ed.). Elsevier. Keywords: NURS 280, Exam 2, ATI, practice questions, verified answers, stress, stress management, distress, coping strategies, General Adaptation Syndrome, GAS, therapeutic communication, assertive communication, cognitive reframing, major depressive disorder, MDD, persistent depressive disorder, postpartum blues, postpartum depression, postpartum psychosis, suicide precautions, substance use disorder, alcohol withdrawal, benzodiazepine withdrawal, disulfiram, pain assessment, acute pain, chronic pain, opioid analgesics, morphine, ketorolac, patient controlled analgesia, PCA, breakthrough pain, multiple sclerosis, MS, baclofen, peripheral arterial disease, PAD, chronic venous insufficiency, CVI, deep vein thrombosis, DVT, pulmonary embolism, anticoagulants, heparin, warfarin, clopidogrel, compression stockings, Crohn's disease, ulcerative colitis, inflammatory bowel disease, IBD, sulfasalazine, prednisone, osteoarthritis, rheumatoid arthritis, psoriasis, photochemotherapy, PUVA, calcipotriene, contact dermatitis, diphenhydramine, autoimmune disorders, inflammatory disorders, musculoskeletal disorders, gastrointestinal disorders, vascular nursing, neurological nursing, psychiatric nursing, ATI review, NCLEX preparation

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NURS 280 Exam 2 ATI Chapters
Questions to Review 2026
Exam Questions and Answers |
Already Graded A+



1. A nurse is preparing to provide an educational seminar on stress to

other nursing staff. Which of the following information should the nurse

include in the discussion?

A. Excessive stressors cause the client to experience distress.

B. The body's initial adaptive response to stress is denial.

C. Absence of stressors results in homeostasis.

,D. Negative, rather than positive, stressors produce a biological

response - ANSWER ✔✔A. CORRECT: Distress is the result of

excessive or damaging stressors, such as anxiety or anger.

2. A nurse is discussing acute vs.prolonged stress with a client. Which of

the following effects should the nurse identify as an acute stress

response? (Select all that apply.)

A. Chronic pain

B. Depressed immune system

C. Increased blood pressure

D. Panic attacks


E. Unhappiness - ANSWER ✔✔B. CORRECT: A depressed immune

system is an indicator of acute stress.

C. CORRECT: Increased blood pressure is an indicator of acute stress.

E. CORRECT: Unhappiness is an indicator of acute stress.

3. A nurse is teaching a client about stress-reduction techniques. Which

of the following client statements indicates understanding of the

teaching?

A. "Cognitive reframing will help me change my

irrational thoughts to something positive."

,B. "Progressive muscle relaxation uses a mechanical device to help me

gain control over my pulse rate."

C."Biofeedback causes my body to release endorphins so that I feel less

stress and anxiety."

D."Mindfulness allows me to prioritize the stressors that I have in my life

so that I have less anxiety." - ANSWER ✔✔A. CORRECT: Cognitive

reframing helps the client look at irrational cognitions (thoughts) in a

more realistic light and to restructure those thoughts in a more positive

way.

4. A nurse is talking with a client who reports she is experiencing

increased stress because her significant other is "pressuring me and my

kids to go live with him. I love him, but I'm not ready to do that." Which of

the following recommendations should the nurse make to promote a

change in the client's situation?

A. Learn to practice mindfulness.

B. Use assertiveness techniques.

C. Exercise regularly.




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, D. Rely on the support of a close friend. - ANSWER ✔✔B.

CORRECT: Assertive communication allows the client to assert her

feelings and then make a change in the situation.

5. A nurse is caring for a client who states, "I'm so stressed at work

because of my coworker. He expects me to finish his work because

he's too lazy!" When discussing effective communication, which

of the following statements by the client to his coworker indicates client

understanding?

A. "You really should complete your own work. I don't think it's right to

expect me to complete your responsibilities."

B. "Why do you expect me to finish your work? You must realize that I

have my own responsibilities."

C."It is not fair to expect me to complete your work. If you continue, then

I will report your behavior to our supervisor."

D."When I have to pick up extra work, I feel very overwhelmed. I need to

focus on my own responsibilities." - ANSWER ✔✔D. CORRECT: This

response demonstrates assertive

communication, which allows the client to state his feelings about the

behavior and then promote a change.

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