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SCI225 / SCI 225 Midterm Exam: Pathophysiology | Nightingale | Latest 2026 / 2027

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SCI225 / SCI 225 Midterm Exam: Pathophysiology | Nightingale | Latest 2026 / 2027 Question: Explain the two most common causes of spinal disk herniation Answer: -Aging (elderly) -Obesity Question: What level of spinal cord is the most common spinal disk herniation? Answer: L4-S1 Question: Define Allo-AB vs Auto-AM (alloantibodies vs autoantibodies) Answer: Alloantibodies - AB against foreign antigen Autoantibodies - Against self

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SCI225 / SCI 225 Midterm Exam:
Pathophysiology | Nightingale |
Latest


Question:
Explain the two most common causes of spinal disk herniation
Answer:


-Aging (elderly)


-Obesity




Question:
What level of spinal cord is the most common spinal disk herniation?
Answer:
L4-S1

,Question:
Define Allo-AB vs Auto-AM (alloantibodies vs autoantibodies)
Answer:
Alloantibodies - AB against foreign antigen


Autoantibodies - Against self




Question:
Alloantibodies
Answer:


-Alloantibodies are immune antibodies that are only produced following
exposure to foreign red blood cell antigens.
-They are produced by exposure to foreign red cell antigens which are non-
self antigens but are of the same species.
-Alloantibodies react only with allogenic cells.
-Exposure to alloantigens can occur through pregnancy or transfusion.

, Question:
Autoantibodies
Answer:


-Autoantibodies are antibodies that react with a person's own red blood
cells.
-They can be produced in an autoimmune process and are directed against
one's own red cell antigens.
-Autoantibodies typically react with the patient's own cells and typically all
cells tested.




Question:
Define hemolytic disease of a newborn
Answer:


-most common cause is maternal made antibodies against Rh positive RBC
of the fetus


-Maternal developed alloantibody Rh antigen since Rh antigen negative
from the first encounter


-Now IgG crosses the placenta and attacks all RBCs with Rh antigen on it

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