BASIC AND CLINICAL PHARMACOLOGY 15TH EDITION KATZUNG TREVOR TEST BANK INCLUSIVE OF CHAPTERS 1-66 COMPLETE WITH EXPLAINED ANSWERS

BASIC AND CLINICAL PHARMACOLOGY 15TH EDITION
KATZUNG TREVOR TEST BANK
INCLUSIVE OF CHAPTERS 1-66 COMPLETE WITH EXPLAINED ANSWERS

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Basic and Clinical Pharmacology 15th Edition Katzung Trevor Test Bank
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Chapter 1. Introduction: The Nature of Drugs & Drug Development & Regulation
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1.
A nurse working in radiology administers iodine to a patient who is havin
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g a computed tomography (CT) scan. The nurse working on the oncology un
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it administers chemotherapy to patients who have cancer. At the Public Healt
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h Department, a nurse administers a measles-mumps-
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rubella (MMR) vaccine to a 14-month- ln ln ln ln ln


old child as a routine immunization. Which branch of pharmacology best des
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cribes the actions of all three nurses?
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A) Pharmacoeconomics
B) Pharmacotherapeutics
C) Pharmacodynamics
D) Pharmacokinetics
Ans: B
Feedback:

Pharmacology is the study of the biologic effects of chemicals. Nurses are in
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volved with clinical pharmacology or pharmacotherapeutics, which is a bran
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ch of pharmacology that deals with the uses of drugs to treat, prevent, and di
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agnose disease. The radiology nurse is administering a drug to help diagnose
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a disease. The oncology nurse is administering a drug to help treat a disease.
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Pharmacoeconomics includes any costs involved in drug therapy. ln ln ln ln ln ln ln


Pharmacodynamics involves how a drug affects the body and pharmacokinetic ln ln ln ln ln ln ln ln ln


s is how the body acts on the body.
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2.
When involved in phase III drug evaluation studies, wh
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at responsibilities would the nurse have?
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A) Working with animals who are given experimental drugs
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B) Choosing appropriate patients to be involved in the drug study
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C) Monitoring and observing patients closely for adverse effects
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D) Conducting research to determine effectiveness of the drugln ln ln ln ln ln ln

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Ans: C
Feedback:

Phase III studies involve use of a drug in a vast clinical population in which
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patients are asked to record any symptoms they experience while taking the
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drugs. Nurses may be responsible for helping collect and analyze the inform
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ation to be shared with the Food and Drug Administration (FDA) but would
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not conduct research independently because nurses do not prescribe medicat
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ions. Use of animals in drug testing is done in the preclinical trials. Select p
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atients who are involved in phase II studies to participate in studies where th
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e participants have the disease the drug is intended to treat. These patients ar
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e monitored closely for drug action and adverse effects. Phase I studies invo
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lve healthy human volunteers who are usually paid for their participation. N
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urses may observe for adverse effects and toxicity.
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3.
A physician has ordered intramuscular (IM) injections of morphine, a nar
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cotic, every 4 hours as needed for pain in a motor vehicle accident victim. Th
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e nurse is aware this drug has a high abuse potential. Under what category w
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ould morphine be classified?
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A) Schedule I ln




B) Schedule II ln




C) Schedule III ln




D) Schedule IV ln




Ans: B
Feedback:

Narcotics with a high abuse potential are classified as Schedule II drugs be
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cause of severe dependence liability. Schedule I drugs have high abuse pot
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ential and no accepted medical use. Schedule III drugs have a lesser abuse
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potential than II and an accepted medical use. Schedule IV drugs have low a
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buse potential and limited dependence liability.
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4.
What concept is considered when generic drugs are substituted for bran
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d name drugs?
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A) Bioavailability

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B) Critical concentration ln




C) Distribution
D) Half-life
Ans: A
Feedback:

Bioavailability is the portion of a dose of a drug that reaches the systemic c ln ln ln ln ln ln ln ln ln ln ln ln ln ln


irculation and is available to act on body cells. Binders used in a generic dr
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ug may not be the same as those used in the brand name drug. Therefore, t
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he way the body breaks down and uses the drug may differ, which may eli
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minate a generic drug substitution. Critical concentration is the amount of a d
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rug that is needed to cause a therapeutic effect and should not differ betwee
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n generic and brand name medications. Distribution is the phase of pharma
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cokinetics, which involves the movement of a drug to the bodys tissues and
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is the same in generic and brand name drugs. A drugs half-
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life is the time it takes for the amount of drug to decrease to half the peak l
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evel, which should not change when substituting a generic medication.
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5.
A nurse is assessing the patients home medication use. After listening to th
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e patient list current medications, the nurse asks what priority question?
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A) Do you take any generic medications?
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B) Are any of these medications orphan drugs?
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C) Are these medications safe to take during pregnancy?
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D) Do you take any over-the-counter medications?
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Ans: D
Feedback:

It is important for the nurse to specifically question use of over-the-
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counter medications because patients may not consider them important. The
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npatient is unlikely to know the meaning of orphan drugs unless they too are
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nhealth care providers. Safety during pregnancy, use of a generic medication
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, or classification of orphan drugs are things the patient would be unable to
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answer but could be found in reference books if the nurse wishes to research t
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hem.