Test Bank Basic and Clinical Pharmacology 15th Edition Bertram G Katzung Exam Questions Answers Study Resource

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BASIC AND CLINICAL PHARMACOLOGY 15TH EDITION
KATZUNG TREVOR TEST BANK
INCLUSIVE OF CHAPTERS 1-66 COMPLETE WITH EXPLAINED ANSWERS
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Basic and Clinical Pharmacology 15th Edition Katzung Trevor Test Bank
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Chapter 1. Introduction: The Nature of Drugs & Drug Development & Regulation
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1.
A nurse working in radiology administers iodine to a patient who is havin
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g a computed tomography (CT) scan. The nurse working on the oncology u
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nit administers chemotherapy to patients who have cancer. At the Public He
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alth Department, a nurse administers a measles-mumps-
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rubella (MMR) vaccine to a 14-month-
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old child as a routine immunization. Which branch of pharmacology best de
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scribes the actions of all three nurses?
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A) Pharmacoeconomics
B) Pharmacotherapeutics
C) Pharmacodynamics
D) Pharmacokinetics
Ans: B
Feedback:

Pharmacology is the study of the biologic effects of chemicals. Nurses are i
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nvolved with clinical pharmacology or pharmacotherapeutics, which is a bra
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nch of pharmacology that deals with the uses of drugs to treat, prevent, and
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diagnose disease. The radiology nurse is administering a drug to help diagn
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ose a disease. The oncology nurse is administering a drug to help treat a dise
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ase. Pharmacoeconomics includes any costs involved in drug therapy.
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Pharmacodynamics involves how a drug affects the body and pharmacokinetic qr qr qr qr qr qr qr qr qr


s is how the body acts on the body.
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2.
When involved in phase III drug evaluation studies, wh
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at responsibilities would the nurse have?
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A) Working with animals who are given experimental drugs
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B) Choosing appropriate patients to be involved in the drug study
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C) Monitoring and observing patients closely for adverse effects
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D) Conducting research to determine effectiveness of the drug
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Ans: C
Feedback:

Phase III studies involve use of a drug in a vast clinical population in which
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patients are asked to record any symptoms they experience while taking the
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drugs. Nurses may be responsible for helping collect and analyze the infor
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mation to be shared with the Food and Drug Administration (FDA) but woul
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d not conduct research independently because nurses do not prescribe medi
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cations. Use of animals in drug testing is done in the preclinical trials. Selec
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t patients who are involved in phase II studies to participate in studies wher
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e the participants have the disease the drug is intended to treat. These patien
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ts are monitored closely for drug action and adverse effects. Phase I studies
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involve healthy human volunteers who are usually paid for their participatio
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n. Nurses may observe for adverse effects and toxicity.
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3.
A physician has ordered intramuscular (IM) injections of morphine, a nar
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cotic, every 4 hours as needed for pain in a motor vehicle accident victim. T
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he nurse is aware this drug has a high abuse potential. Under what category
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would morphine be classified? qr qr qr




A) Schedule I qr




B) Schedule II qr




C) Schedule III qr




D) Schedule IV qr




Ans: B
Feedback:

Narcotics with a high abuse potential are classified as Schedule II drugs be
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cause of severe dependence liability. Schedule I drugs have high abuse pot
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ential and no accepted medical use. Schedule III drugs have a lesser abuse
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potential than II and an accepted medical use. Schedule IV drugs have low a
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buse potential and limited dependence liability.
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4.
What concept is considered when generic drugs are substituted for bra
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nd name drugs?
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A) Bioavailability

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B) Critical concentration qr




C) Distribution
D) Half-life
Ans: A
Feedback:

Bioavailability is the portion of a dose of a drug that reaches the systemic qr qr qr qr qr qr qr qr qr qr qr qr qr qr


circulation and is available to act on body cells. Binders used in a generic
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drug may not be the same as those used in the brand name drug. Therefore
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, the way the body breaks down and uses the drug may differ, which may
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eliminate a generic drug substitution. Critical concentration is the amount of
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a drug that is needed to cause a therapeutic effect and should not differ bet
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ween generic and brand name medications. Distribution is the phase of ph
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armacokinetics, which involves the movement of a drug to the bodys tissu qr qr qr qr qr qr qr qr qr qr qr


es and is the same in generic and brand name drugs. A drugs half-
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life is the time it takes for the amount of drug to decrease to half the peak
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level, which should not change when substituting a generic medication.
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5.
A nurse is assessing the patients home medication use. After listening to t
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he patient list current medications, the nurse asks what priority question?
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A) Do you take any generic medications?
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B) Are any of these medications orphan drugs?
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C) Are these medications safe to take during pregnancy?
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D) Do you take any over-the-counter medications?
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Ans: D
Feedback:

It is important for the nurse to specifically question use of over-the-
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counter medications because patients may not consider them important. Th
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e patient is unlikely to know the meaning of orphan drugs unless they too a
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re health care providers. Safety during pregnancy, use of a generic medicati
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on, or classification of orphan drugs are things the patient would be unable
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to answer but could be found in reference books if the nurse wishes to resear
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