Ca2+ channel blockers exert their effects primarily in which part of the heart?
Nodes
Atria
Ventricals
Cardiomyocytes
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Nodes
A Ca2+ channel blocker would be expected to alleviate which mechanism of
arrhythmia?
Enhanced normal automaticity
Abnormal automaticity
, Early afterdepolarizations
Delayed afterdepolarizations
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Delayed afterdepolarizations
*ANTIARRHYTHMIC DRUGS*
SODIUM CHANNEL BLOCKERS (CLASS 1B)
SLIGHTLY DECREASE AP DURATION
DIRECT EFFECTS:
- DECREASED AP duration slightly (dissociates rapidly at resting Em)
- NO CHANGE in ERP at normal heart rates
SIDE EFFECTS:
- Dizziness, seizures
- IV ONLY (rapid first pass metabolism)
USE:
- V-tach
- AMI (Acute myocardial infarctions)
- DIGITALIS-INDUCED ARRHYTHMIAS
Give this one a try later!
Lidocaine
Mexiletine
Phenytoin
Nodes
Atria
Ventricals
Cardiomyocytes
Give this one a try later!
Nodes
A Ca2+ channel blocker would be expected to alleviate which mechanism of
arrhythmia?
Enhanced normal automaticity
Abnormal automaticity
, Early afterdepolarizations
Delayed afterdepolarizations
Give this one a try later!
Delayed afterdepolarizations
*ANTIARRHYTHMIC DRUGS*
SODIUM CHANNEL BLOCKERS (CLASS 1B)
SLIGHTLY DECREASE AP DURATION
DIRECT EFFECTS:
- DECREASED AP duration slightly (dissociates rapidly at resting Em)
- NO CHANGE in ERP at normal heart rates
SIDE EFFECTS:
- Dizziness, seizures
- IV ONLY (rapid first pass metabolism)
USE:
- V-tach
- AMI (Acute myocardial infarctions)
- DIGITALIS-INDUCED ARRHYTHMIAS
Give this one a try later!
Lidocaine
Mexiletine
Phenytoin
