University of Texas at Arlington (UTA)NURS 5334
Advanced Pharmacology Quiz 2 Study Guide &100
Practice Questions with Rationales & Answers
(Graded A+)
NB ALL ANSWERS AVAILABLE
Description:
Pass your NURS 5334 Advanced Pharmacology Quiz 2 on your first try!
This comprehensive 100-question practice exam and high-yield study guide is specifically designed for
APRN / MSN students preparing for Quiz 2 in NURS 5334.
What’s Included:
High-Yield Concept Summaries: Key principles covering Antihypertensives, Antiarrhythmics,
Asthma/COPD, Autonomic/Cholinergic Agents, Endocrine, and Pharmacokinetics.
100 Multiple-Choice Practice Questions: Standardized board/quiz-style practice covering
cardiovascular, respiratory, renal, endocrine, GI, and advanced pharmacokinetics.
Detailed Explanations & Rationales: Every question comes with a verified answer key and
clinical rationale to help reinforce complex drug mechanisms, black box warnings, and drug
interactions.
Part 1: Core Pharmacological Principles & High-Yield Topics
Before diving into the practice questions, review these essential high-yield concepts
commonly tested in Advanced Pharmacology Quiz 2:
1. Cardiovascular & Renal Systems
ACE Inhibitors (-pril) & ARBs (-sartan):
, o Mechanism: ACE inhibitors block conversion of Angiotensin I to Angiotensin
II, preventing vasoconstriction and aldosterone release. ARBs directly block
AT1 receptors.
o Key Adverse Effects: ACE inhibitors cause a dry cough (due to bradykinin
accumulation) and angioedema. Both can cause hyperkalemia and acute
kidney injury (AKI) in renal artery stenosis.
o Contraindications: Absolute contraindication in pregnancy (black box warning
for teratogenicity/fetal harm).
Beta-Blockers (-olol):
o Selectivity: Cardioselective ($\beta_1$-selective) agents include Atenolol,
Metoprolol, and Bisoprolol (safe/preferred in mild reactive airway disease).
Non-selective agents like Propranolol block $\beta_1$ and $\beta_2$
(contraindicated in asthma/COPD).
o Indications: Heart failure with reduced ejection fraction (HFrEF), post-MI,
angina, rate control in AFib.
o Counseling: Never abruptly stop taking beta-blockers due to risk of rebound
hypertension and myocardial ischemia.
Calcium Channel Blockers (CCBs):
o Dihydropyridines (Amlodipine, Nifedipine): Potent peripheral vasodilators;
main side effect is peripheral edema.
o Non-Dihydropyridines (Verapamil, Diltiazem): Act on SA/AV nodes to lower
heart rate and contractility; avoid in HFrEF with severe systolic dysfunction.
Diuretics:
o Thiazides (HCTZ, Chlorthalidone): First-line for hypertension; cause
hypokalemia, hyponatremia, hyperuricemia (precipitates gout), and
hyperglycemia.
, o Loop Diuretics (Furosemide, Bumetanide): Inhibit
$\text{Na}^+/\text{K}^+/2\text{Cl}^-$ in the thick ascending Limb of Henle;
used for volume overload/edema. Watch for hypokalemia and ototoxicity.
o Potassium-Sparing / Aldosterone Antagonists (Spironolactone, Eplerenone):
Inhibit aldosterone in the distal tubule; risk of hyperkalemia and gynecomastia
(with spironolactone).
2. Respiratory Systems
Asthma & COPD Management:
o SABA (Albuterol): Short-acting $\beta_2$-agonist for acute bronchospasm.
o ICS (Fluticasone, Budesonide): Mainstay of long-term asthma control;
reduces airway inflammation. Patient teaching: Rinse mouth after use to
prevent oral candidiasis (thrush).
o LAMA (Tiotropium): First-line maintenance for COPD; blocks M3 muscarinic
receptors causing bronchodilation.
3. Autonomic & Neuropharmacology
Cholinergic vs. Anticholinergic Signals:
o Cholinergic (Parasympathetic): SLUDGE (Salivation, Lacrimation, Urination,
Defecation, Gastrointestinal distress, Emesis).
o Anticholinergic (Sympathetic-like): "Dry as a bone, blind as a bat, red as a
beet, mad as a hatter, hot as a hare" (urinary retention, constipation, dry
mouth, blurred vision/mydriasis, tachycardia).
Questions 1–25: Cardiovascular Pharmacology
Q1
, A 58-year-old male with hypertension and stage 3 chronic kidney disease (CKD) is started
on lisinopril. Which laboratory test must be rechecked within 1 to 2 weeks of initiating
therapy?
A) Serum calcium and albumin
B) Serum potassium and creatinine
C) Complete blood count (CBC) and liver function tests (LFTs)
D) Fasting blood glucose and uric acid
Q2
A patient with a history of hypertension and heart failure with reduced ejection fraction
(HFrEF) is prescribed metoprolol succinate. Which statement accurately describes the
mechanism by which this medication improves long-term outcomes in HFrEF?
A) Decreases renal perfusion to reduce intravascular volume
B) Blocks sympathetic neurohormonal toxicity on the myocardium
C) Increases systemic vascular resistance to improve coronary perfusion
D) Stimulates cardiac $\beta_2$-receptors to increase stroke volume
Q3
Which anti-hypertensive class is considered first-line for a pregnant patient with chronic
hypertension?
A) Lisinopril
B) Losartan
C) Labetalol
D) Spironolactone
Advanced Pharmacology Quiz 2 Study Guide &100
Practice Questions with Rationales & Answers
(Graded A+)
NB ALL ANSWERS AVAILABLE
Description:
Pass your NURS 5334 Advanced Pharmacology Quiz 2 on your first try!
This comprehensive 100-question practice exam and high-yield study guide is specifically designed for
APRN / MSN students preparing for Quiz 2 in NURS 5334.
What’s Included:
High-Yield Concept Summaries: Key principles covering Antihypertensives, Antiarrhythmics,
Asthma/COPD, Autonomic/Cholinergic Agents, Endocrine, and Pharmacokinetics.
100 Multiple-Choice Practice Questions: Standardized board/quiz-style practice covering
cardiovascular, respiratory, renal, endocrine, GI, and advanced pharmacokinetics.
Detailed Explanations & Rationales: Every question comes with a verified answer key and
clinical rationale to help reinforce complex drug mechanisms, black box warnings, and drug
interactions.
Part 1: Core Pharmacological Principles & High-Yield Topics
Before diving into the practice questions, review these essential high-yield concepts
commonly tested in Advanced Pharmacology Quiz 2:
1. Cardiovascular & Renal Systems
ACE Inhibitors (-pril) & ARBs (-sartan):
, o Mechanism: ACE inhibitors block conversion of Angiotensin I to Angiotensin
II, preventing vasoconstriction and aldosterone release. ARBs directly block
AT1 receptors.
o Key Adverse Effects: ACE inhibitors cause a dry cough (due to bradykinin
accumulation) and angioedema. Both can cause hyperkalemia and acute
kidney injury (AKI) in renal artery stenosis.
o Contraindications: Absolute contraindication in pregnancy (black box warning
for teratogenicity/fetal harm).
Beta-Blockers (-olol):
o Selectivity: Cardioselective ($\beta_1$-selective) agents include Atenolol,
Metoprolol, and Bisoprolol (safe/preferred in mild reactive airway disease).
Non-selective agents like Propranolol block $\beta_1$ and $\beta_2$
(contraindicated in asthma/COPD).
o Indications: Heart failure with reduced ejection fraction (HFrEF), post-MI,
angina, rate control in AFib.
o Counseling: Never abruptly stop taking beta-blockers due to risk of rebound
hypertension and myocardial ischemia.
Calcium Channel Blockers (CCBs):
o Dihydropyridines (Amlodipine, Nifedipine): Potent peripheral vasodilators;
main side effect is peripheral edema.
o Non-Dihydropyridines (Verapamil, Diltiazem): Act on SA/AV nodes to lower
heart rate and contractility; avoid in HFrEF with severe systolic dysfunction.
Diuretics:
o Thiazides (HCTZ, Chlorthalidone): First-line for hypertension; cause
hypokalemia, hyponatremia, hyperuricemia (precipitates gout), and
hyperglycemia.
, o Loop Diuretics (Furosemide, Bumetanide): Inhibit
$\text{Na}^+/\text{K}^+/2\text{Cl}^-$ in the thick ascending Limb of Henle;
used for volume overload/edema. Watch for hypokalemia and ototoxicity.
o Potassium-Sparing / Aldosterone Antagonists (Spironolactone, Eplerenone):
Inhibit aldosterone in the distal tubule; risk of hyperkalemia and gynecomastia
(with spironolactone).
2. Respiratory Systems
Asthma & COPD Management:
o SABA (Albuterol): Short-acting $\beta_2$-agonist for acute bronchospasm.
o ICS (Fluticasone, Budesonide): Mainstay of long-term asthma control;
reduces airway inflammation. Patient teaching: Rinse mouth after use to
prevent oral candidiasis (thrush).
o LAMA (Tiotropium): First-line maintenance for COPD; blocks M3 muscarinic
receptors causing bronchodilation.
3. Autonomic & Neuropharmacology
Cholinergic vs. Anticholinergic Signals:
o Cholinergic (Parasympathetic): SLUDGE (Salivation, Lacrimation, Urination,
Defecation, Gastrointestinal distress, Emesis).
o Anticholinergic (Sympathetic-like): "Dry as a bone, blind as a bat, red as a
beet, mad as a hatter, hot as a hare" (urinary retention, constipation, dry
mouth, blurred vision/mydriasis, tachycardia).
Questions 1–25: Cardiovascular Pharmacology
Q1
, A 58-year-old male with hypertension and stage 3 chronic kidney disease (CKD) is started
on lisinopril. Which laboratory test must be rechecked within 1 to 2 weeks of initiating
therapy?
A) Serum calcium and albumin
B) Serum potassium and creatinine
C) Complete blood count (CBC) and liver function tests (LFTs)
D) Fasting blood glucose and uric acid
Q2
A patient with a history of hypertension and heart failure with reduced ejection fraction
(HFrEF) is prescribed metoprolol succinate. Which statement accurately describes the
mechanism by which this medication improves long-term outcomes in HFrEF?
A) Decreases renal perfusion to reduce intravascular volume
B) Blocks sympathetic neurohormonal toxicity on the myocardium
C) Increases systemic vascular resistance to improve coronary perfusion
D) Stimulates cardiac $\beta_2$-receptors to increase stroke volume
Q3
Which anti-hypertensive class is considered first-line for a pregnant patient with chronic
hypertension?
A) Lisinopril
B) Losartan
C) Labetalol
D) Spironolactone
