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ACLS EXAM VERSION A 2026 – 350 PRACTICE QUESTIONS WITH ANSWERS & RATIONALES

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Ace your ACLS certification exam with confidence! This comprehensive study guide contains 350 practice questions and detailed answer rationales, providing the ultimate preparation for the AHA ACLS written exam and megacode skills test. Updated for 2026, this resource is your key to mastering the algorithms and passing on your first attempt. Are you a healthcare professional preparing for the Advanced Cardiovascular Life Support (ACLS) certification or recertification? This essential study guide is designed to help you master the knowledge and clinical decision-making required to lead and participate in cardiac arrest resuscitations and other cardiovascular emergencies.

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ACLS EXAM VERSION A 2026 – 350
PRACTICE QUESTIONS WITH ANSWERS
& RATIONALES



Section 1: High Quality CPR & BLS Foundations (Questions 1–40)


1. What is the recommended compression rate during highquality CPR?
A. 80–90/min
B. 100–120/min
C. 120–140/min
D. 60–80/min


Correct Answer: B
Rationale: High quality CPR requires a compression rate of 100–120 per
minute to maintain adequate coronary and cerebral perfusion.


2. What is the FIRST action in a witnessed cardiac arrest in a hospital?
A. Intubate immediately
B. Start chest compressions
C. Check pulse for 2 minutes
D. Give epinephrine

,Correct Answer: B
Rationale: Immediate chest compressions improve survival and should be
started without delay.


3. What is the recommended compressiontoventilation ratio for an adult
WITHOUT an advanced airway?
A. 15:2
B. 30:2
C. 20:2
D. 10:1


Correct Answer: B
Rationale: ACLS recommends a 30:2 ratio for adults without an advanced
airway to ensure adequate perfusion and oxygenation.


4. Compression depth for an adult should be:
A. At least 1.5 inches
B. At least 2 inches (5 cm)
C. At least 2.4 inches (6 cm)
D. Between 1 and 1.5 inches


Correct Answer: B
Rationale: AHA guidelines recommend at least 2 inches (5 cm), but not exceed
2.4 inches (6 cm).


5. Chest compression fraction should be at least:

,A. 50%
B. 60%
C. 70%
D. 80%


Correct Answer: B
Rationale: AHA recommends ≥60% chest compression fraction, with ideal
>80% to maximize perfusion.


6. After placing an advanced airway (ET tube), compressions should be:
A. Paused for each breath
B. Continuous at 100120/min with breaths q6s (10 breaths/min)
C. 30:2 regardless
D. 15:2


Correct Answer: B
Rationale: Continuous compressions without pauses. Give 1 breath every 6
seconds (10/min).


7. What is the maximum interval for rhythm checks during CPR?
A. 1 minute
B. 2 minutes
C. 3 minutes
D. 4 minutes


Correct Answer: B

, Rationale: Check rhythm every 2 minutes (after 5 cycles of 30:2 or 2 minutes
of CPR).


8. Agonal gasping is:
A. A sign of effective breathing
B. Not considered normal breathing; treat as cardiac arrest
C. An indication to stop compressions
D. Always present in VF arrest


Correct Answer: B
Rationale: Agonal gasping is abnormal and common in early cardiac arrest. Do
not mistake for normal breathing.


9. Complete chest recoil allows:
A. Faster compression rate
B. Venous return and coronary perfusion
C. Less fatigue for rescuer
D. Higher tidal volume


Correct Answer: B
Rationale: Recoil creates negative intrathoracic pressure, enhancing venous
return and cardiac output.


10. What is the correct rate for bagmask ventilation during CPR when an
advanced airway is in place?
A. 5–6/min

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