COMLEX Level 2–style Exam Newest With Complete Questions And
Correct Detailed Answers| Brand New Version!
Question 1
A 67-year-old man presents with crushing substernal chest pain
radiating to his left arm that began 45 minutes ago. ECG demonstrates
ST-segment elevation in leads II, III, and aVF. Blood pressure is 92/60
mm Hg, and lung examination is clear. Which diagnosis is most likely?
A. Stable angina
B. Inferior ST-elevation myocardial infarction (STEMI)
C. Acute pericarditis
D. Pulmonary embolism
Correct Answer: B. Inferior ST-Elevation Myocardial Infarction (STEMI)
Rationale:
ST-segment elevation in leads II, III, and aVF localizes an acute inferior-
wall myocardial infarction, typically involving the right coronary artery.
Hypotension with clear lungs raises concern for right ventricular
involvement.
Question 2
A 28-year-old woman presents with fever, dysuria, flank pain, and
costovertebral angle tenderness. Urinalysis reveals positive leukocyte
esterase, nitrites, and numerous white blood cells. Which diagnosis is
most likely?
A. Acute cystitis
B. Pyelonephritis
, C. Interstitial cystitis
D. Nephrolithiasis
Correct Answer: B. Pyelonephritis
Rationale:
Flank pain, fever, CVA tenderness, and evidence of urinary infection
indicate an upper urinary tract infection involving the kidneys.
Question 3
A patient with poorly controlled diabetes develops a warm,
erythematous lower leg with rapidly spreading borders and fever.
Which organism is the most likely cause?
A. Escherichia coli
B. Staphylococcus aureus
C. Mycoplasma pneumoniae
D. Clostridioides difficile
Correct Answer: B. Staphylococcus aureus
Rationale:
Staphylococcus aureus and Streptococcus pyogenes are common causes
of cellulitis. Diabetes increases the risk of skin and soft tissue infections.
Question 4
A 56-year-old man presents with progressive fatigue and iron-deficiency
anemia. Colonoscopy reveals a mass in the ascending colon. Which
symptom is most commonly associated with right-sided colon cancer?
Correct Detailed Answers| Brand New Version!
Question 1
A 67-year-old man presents with crushing substernal chest pain
radiating to his left arm that began 45 minutes ago. ECG demonstrates
ST-segment elevation in leads II, III, and aVF. Blood pressure is 92/60
mm Hg, and lung examination is clear. Which diagnosis is most likely?
A. Stable angina
B. Inferior ST-elevation myocardial infarction (STEMI)
C. Acute pericarditis
D. Pulmonary embolism
Correct Answer: B. Inferior ST-Elevation Myocardial Infarction (STEMI)
Rationale:
ST-segment elevation in leads II, III, and aVF localizes an acute inferior-
wall myocardial infarction, typically involving the right coronary artery.
Hypotension with clear lungs raises concern for right ventricular
involvement.
Question 2
A 28-year-old woman presents with fever, dysuria, flank pain, and
costovertebral angle tenderness. Urinalysis reveals positive leukocyte
esterase, nitrites, and numerous white blood cells. Which diagnosis is
most likely?
A. Acute cystitis
B. Pyelonephritis
, C. Interstitial cystitis
D. Nephrolithiasis
Correct Answer: B. Pyelonephritis
Rationale:
Flank pain, fever, CVA tenderness, and evidence of urinary infection
indicate an upper urinary tract infection involving the kidneys.
Question 3
A patient with poorly controlled diabetes develops a warm,
erythematous lower leg with rapidly spreading borders and fever.
Which organism is the most likely cause?
A. Escherichia coli
B. Staphylococcus aureus
C. Mycoplasma pneumoniae
D. Clostridioides difficile
Correct Answer: B. Staphylococcus aureus
Rationale:
Staphylococcus aureus and Streptococcus pyogenes are common causes
of cellulitis. Diabetes increases the risk of skin and soft tissue infections.
Question 4
A 56-year-old man presents with progressive fatigue and iron-deficiency
anemia. Colonoscopy reveals a mass in the ascending colon. Which
symptom is most commonly associated with right-sided colon cancer?
