243 EXAM 2 QUESTIONS AND ANSWERS |
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,H2 blocker adverse effects - serious effects are uncommon
- antiandrogenic effects
- CNS effects
- pneumonia
H2 blocker drug interactions - warfarin
- phenytoin
- theophylline
- lidocaine
- all increase blood levels
- antacids can decrease absorption, so they should be administered at least 1 hr apart
Cimetidine class H2 receptor antagonist (H2 blocker)
Cimetidine MOA blocks H2 receptors on gastric parietal cells -> reduces gastric acid secretion/volume
Cimetidine indications - GERD
- PUD
- Zollinger-Ellison syndrome
- heartburn
Cimetidine route/dosage - oral, IM, IV
- 300mg BID, 800mg @ bedtime
Cimetidine side effects - gynecomastia
- decreased libido
- CNS effects
- diarrhea
- headache
Cimetidine warnings use with caution in elderly or renal impairment
Cimetidine considerations - administer with meals or at bedtime
- monitor for mental status changes
Omeprazole class Proton pump inhibitor (PPI)
, Omeprazole MOA inhibits H+/K+ ATPase enzyme in gastric parietal cells -> suppresses gastric acid secretion
by blocking final step of acid production
Omeprazole indications - GERD
- PUD
- Zollinger-Ellison Syndrome
- Erosive Esophagus
- H. Pylori eradication
Omeprazole route/dosage Oral, IV -> dosage 20-40mg daily
Omeprazole side effects - headache
- nausea
- abdominal pain
- osteoporosis
- vitamin B12 deficiency
- magnesium deficiency
- C. Diff
- kidney failure
Omeprazole warnings use with cautions in patients with osteoporosis or malabsorption issues
Omeprazole considerations - administer 30-60 mins before meals
- dont crush/chew delayed release capsules
- monitor for C. Diff
- may interact with clopidogrel (reduces antiplatelet)
Bulk forming laxatives administration Mix in glass of water or juice.
Stir and drink immediately.
Follow with 1 glass water.
Lactulose (ammonia) uses - constipation
- hepatic encephalopathy -> reduces ammonia
Magnesium hydroxide contraindications Patients with CHF
Renal failure & elderly may develop hypermagnesemia
Montelukast class leukotriene receptor antagonist