ANFS 300 EXAM 3 QUESTIONS WITH VERIFIED
ANSWERS
DNA methylation - Answers - Association of lysine 9 methylated histones with DNA
promotes methylation of cytosine
Epigenetics - Answers - Histone modification and DNA methylation can be inherited by
daughter cells
What is epigenetics the basis of - Answers - Epigenetic inheritance and imprinting
Insulin like growth factor 2 - Answers - Parental side
H19 - Answers - Maternal side
Synonymous mutations - Answers - Codon specifies same amino acid (wobble effect)
Missense mutations - Answers - Conservative: codon specifies chemically similar amino
acid, Nonconservative: codon specifies different amino acids
Nonsense mutations - Answers - Codon for one amino acid is changed into a translation
terminaiton
Frameshift mutation - Answers - Insertion or deletion of one of more nucleotides, results
in a change of the translational reading frame
Open reading frames - Answers - These mutation directly effect protein structure, Could
lead to loss of function or gain of function
Regulatory/non coding genes - Answers - These mutations directly effect expression
patterns
Somatic mutations - Answers - Mutations occurring in somatic cells during development
or in adulthood, Not inherited because not in germ line
Germline mutations - Answers - Mutations that occur in the cell lineage that is destined
to become gametes
Fragile X syndrome - Answers - Typical individual has around 30 CGG repeats
Hardy-Weinberg Equilibrium - Answers - P2 + 2PQ + Q2 = 1
ANSWERS
DNA methylation - Answers - Association of lysine 9 methylated histones with DNA
promotes methylation of cytosine
Epigenetics - Answers - Histone modification and DNA methylation can be inherited by
daughter cells
What is epigenetics the basis of - Answers - Epigenetic inheritance and imprinting
Insulin like growth factor 2 - Answers - Parental side
H19 - Answers - Maternal side
Synonymous mutations - Answers - Codon specifies same amino acid (wobble effect)
Missense mutations - Answers - Conservative: codon specifies chemically similar amino
acid, Nonconservative: codon specifies different amino acids
Nonsense mutations - Answers - Codon for one amino acid is changed into a translation
terminaiton
Frameshift mutation - Answers - Insertion or deletion of one of more nucleotides, results
in a change of the translational reading frame
Open reading frames - Answers - These mutation directly effect protein structure, Could
lead to loss of function or gain of function
Regulatory/non coding genes - Answers - These mutations directly effect expression
patterns
Somatic mutations - Answers - Mutations occurring in somatic cells during development
or in adulthood, Not inherited because not in germ line
Germline mutations - Answers - Mutations that occur in the cell lineage that is destined
to become gametes
Fragile X syndrome - Answers - Typical individual has around 30 CGG repeats
Hardy-Weinberg Equilibrium - Answers - P2 + 2PQ + Q2 = 1
