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BSN 266 HESI MED-SURG EXAM - 350 PRACTICE QUESTIONS WITH ANSWERS & RATIONALES

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Are you a nursing student preparing for the BSN 266 HESI Medical-Surgical Nursing exam? This comprehensive study guide is the ultimate resource to help you master the material and pass your exit exam with confidence. Designed for the 2026/2027 academic year, this book covers all essential content areas you need to succeed on the HESI. Inside, you'll find 350 carefully curated practice questions meticulously organized into 10 key sections, including Cardiovascular, Respiratory, Gastrointestinal, Renal, Endocrine, Neurological, and Musculoskeletal systems. Each question is designed to challenge your clinical reasoning and test your ability to apply nursing knowledge in real-world scenarios. What sets this guide apart is the inclusion of detailed rationales for every single answer. You won't just memorize the correct letter—you'll understand the why behind each answer, solidifying your understanding of pathophysiology, pharmacology, and nursing interventions. This book is more than just a practice test; it's a comprehensive learning tool. Each rationale provides a concise, exam-focused explanation to reinforce key concepts and build the critical thinking skills essential for the HESI exam and for safe nursing practice. The included answer key allows for quick self-assessment, making it the perfect resource for both structured study sessions and last-minute cramming. Ideal for nursing students in the final semester of their BSN program, this guide is your key to acing the HESI Med-Surg exam and launching your nursing career. Don't just prepare—dominate the HESI exam with confidence.

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BSN 266 HESI MED-SURG EXAM - 350
PRACTICE QUESTIONS WITH ANSWERS
& RATIONALES



CARDIOVASCULAR SYSTEM (Questions 1-70)


---


Question 1
A patient with heart failure is prescribed furosemide (Lasix). Which
electrolyte imbalance should the nurse monitor most closely?
A) Hyperkalemia
B) Hypokalemia
C) Hypernatremia
D) Hypermagnesemia


Correct Answer: B
Rationale: Furosemide is a loop diuretic that causes potassium wasting,
leading to hypokalemia, which increases the risk of digoxin toxicity and
arrhythmias.


---

,Question 2
A patient with heart failure with reduced ejection fraction (HFrEF) should be
prescribed which first-line medications?
A) ACE inhibitor and beta-blocker
B) Calcium channel blocker and loop diuretic
C) Digoxin and spironolactone
D) Hydralazine and isosorbide dinitrate


Correct Answer: A
Rationale: ACE inhibitors and beta-blockers are the cornerstone of HFrEF
therapy, improving mortality and morbidity.


---


Question 3
A patient with acute decompensated heart failure is given IV furosemide. The
primary purpose is to:
A) Increase contractility
B) Reduce preload
C) Decrease afterload
D) Increase heart rate


Correct Answer: B
Rationale: Furosemide reduces preload by promoting diuresis and decreasing
blood volume.

,---


Question 4
A client presents to the emergency department reporting chest pain that
radiates to the left arm, shortness of breath, and diaphoresis. Which
medication should the nurse anticipate being prescribed?
A) Fentanyl
B) Hydromorphone
C) Oxycodone
D) Morphine


Correct Answer: D
Rationale: Morphine is the analgesic of choice for acute myocardial infarction
because it reduces pain, preload, and myocardial oxygen demand.


---


Question 5
What laboratory test result should a client with a diagnosis of myocardial
infarction ten hours ago exhibit?
A) Elevated creatine kinase-MB
B) Elevated troponin
C) Elevated LDH
D) Elevated myoglobin


Correct Answer: C

, Rationale: LDH begins to rise 8-12 hours after MI and peaks at 24-48 hours,
making it detectable at 10 hours post-MI.


---


Question 6
A client with atrial fibrillation should be prepared for which treatment
protocol based on analysis?
A) Anticoagulation therapy
B) Antiarrhythmic therapy
C) Pacemaker insertion
D) Cardiac ablation


Correct Answer: A
Rationale: Atrial fibrillation increases the risk of thrombus formation and
stroke; anticoagulation therapy is the priority treatment.


---


Question 7
Three weeks post-MI, a client reports his wife moved to a separate bedroom
and states, "I guess we will never have sex again." What is the nurse's best
response?
A) "Sexual activity has similar cardiac workload as climbing two flights of
stairs and can be resumed like other activities."
B) "You should avoid sexual activity for at least six months."
C) "This is a common fear; I will notify the physician."

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