SKIP TO:
BLOCK 1
BLOCK 2
BLOCK 3
BLOCK 4 NBME 2 BLOCK 1-4
,*Lipopolysacharides(Bacteria)
LPS bind to "Toll-like receptor"(TLR) (a single Transmembrane receptor)------> activation of
Inhibitory kappa B kinase (IKB kinase)------->
Note: NF-kB is a transcription Factor that exist in cytoplasm bound to Inhibitory kappa B (IKB)
protein in Inactive form [NF-kB=IKB]
so continuing the above sequence ..
LPS----> TLR---->+IKB kinase----->phosphorylation of IKB of the complex[NF-kB=IKB] and now this
phosphorylated IKB get degraded and NF-kB is released----->NF-kB move to Nucleus where it
upregulate gene expression of TNF------>Sepsis
,
,
BLOCK 1
BLOCK 2
BLOCK 3
BLOCK 4 NBME 2 BLOCK 1-4
,*Lipopolysacharides(Bacteria)
LPS bind to "Toll-like receptor"(TLR) (a single Transmembrane receptor)------> activation of
Inhibitory kappa B kinase (IKB kinase)------->
Note: NF-kB is a transcription Factor that exist in cytoplasm bound to Inhibitory kappa B (IKB)
protein in Inactive form [NF-kB=IKB]
so continuing the above sequence ..
LPS----> TLR---->+IKB kinase----->phosphorylation of IKB of the complex[NF-kB=IKB] and now this
phosphorylated IKB get degraded and NF-kB is released----->NF-kB move to Nucleus where it
upregulate gene expression of TNF------>Sepsis
,
,
