3 parts of the neurodevelopmental evaluation
1) Defining developmental level in multiple domains (e.g. language, motor, visual-
spatial, attention and social)
2) Determining etiology of developmental delays
3) Planning a tx program
3 VERY EARLY components of child's medical history to identify conditions that
might compromise CNS function
1) Pregnancy
2) Labor
3) Delivery
Examples of dysmorphic features to make note of in the neurodevelopmental
examination
+ Epicanthal folds
+ Palpebral fissure size
+ Shape and length of philtrum
+ Low set or posteriorly rotated ears
+ Prominent ear pinnae
+ Unusual dermatoglyphics (e.g. single transverse palmar crease)
,+ Hyperextensibility of joints
+ Syndactyly or clinodactyly
Diagnostic criteria for ADHD in children
+ ≥ 6 symptoms of inattention or hyperactivity/impulsivity persisting for ≥ 6 months
which is maladaptive AND inconsistent with developmental level:
+ Onset is ≤ 12 y.o.
+ Several sx are present in 2 or more settings (e.g. home, school, work; with friends or
relatives; in other activities)
+ Evidence that sx causes distress or impairment of social, academic or
occupational functioning
+ Do not exclusively occur during course of a psychotic disorder, and are not better
explained by another mental disorder
Differences in diagnostic criteria for ADHD in children with ASD?
For children > 17 and adults with ASD, only 5 symptoms from the "Inattention" or
"Impulsivity/Hyperactivity" domains are required.
With regard to ADHD dx, girls have a ↑ prevalence of the _______ type and boys
have a ↑ prevalence of the ______ type.
Girls = Inattentive
Boys = Hyperactive
,SELECT ALL THAT APPLY: Which features of ADHD often persist into adolescence
and adulthood?
a) Hyperactivity
b) Impulsivity
c) Inattentiveness
B, C
Relationship between Tourette's and ADHD?
+ Up to 25% of kids with ADHD have Tourette's
+ Over 50% of kids with Tourette's have ADHD
What genetic disorders are also associated with ADHD?
+ Fragile X
+ Williams Syndrome
+ Angelman Syndrome
+ Kleinfelter Syndrome
+ Turner Syndrome
True/False: Hyperthyroidism can sometimes cause ADHD?
, TRUE
Extended-release stimulant medications for ADHD
+ Methylphenidate (Ritalin LA or SR, Concerta, Quillivant SR, Daytrana patch,
Contempla ODT)
+ Dexmethylphenidate (Focalin XR)
+ Detroamphetamine (Dexedrine CR)
+ Mixed amphetamine (Adderall XR, Mydayis)
+ Lisdexamfetamine (Vyvanse)
Examples of non-stimulant medications for ADHD
SNRI
+ Atomoxetine (Strattera)
--- 2nd line med (per Hay) or as an adjunct to stimulants.
---LOW ABUSE POTENTIAL
---Good for comorbid tic, anxiety or substance abuse disorder
---Effect not seen for 2 - 4 weeks!
α-adrenergic agonists
+ Clonidine (Kapvay XR) --