NCLEX-RN Pharmacology Reproductive &
Genitourinary System Exam Questions and
Answers |
20 NGN-Style Practice MCQs with Rationales |
ATI Pharmacology Made Easy Review 2026
Question 1
Clinical Scenario
A 24-year-old female is prescribed a combined oral
contraceptive containing ethinyl estradiol and norethindrone.
During a follow-up visit, she reports smoking one pack of
cigarettes daily and asks about medication safety.
Question Stem
Which information is most important for the nurse to provide?
A. Smoking increases the effectiveness of oral contraceptives.
B. Smoking while taking combined oral contraceptives increases
the risk of thromboembolic events.
C. Oral contraceptives should be discontinued during
,menstruation.
D. Combined oral contraceptives prevent all sexually
transmitted infections.
Correct Answer
B. Smoking while taking combined oral contraceptives
increases the risk of thromboembolic events.
Detailed Rationale
Combined oral contraceptives contain estrogen, which
increases coagulation factors and the risk of venous
thromboembolism, stroke, and myocardial infarction. Smoking
further increases cardiovascular and thrombotic risk,
particularly in women older than 35 years, but smoking is a
concern at any age. Patient education regarding smoking
cessation is a priority safety intervention.
Option A is incorrect because smoking does not increase
contraceptive effectiveness. Option C is incorrect because oral
contraceptives should be taken consistently according to the
prescribed schedule, including during menstruation. Option D is
incorrect because hormonal contraceptives do not protect
against sexually transmitted infections; barrier methods are
necessary for STI prevention.
The nurse should assess additional risk factors such as
hypertension, obesity, migraines with aura, and history of
, thromboembolic disease. Teaching should emphasize
recognizing symptoms of thrombosis such as unilateral leg
swelling, chest pain, and sudden shortness of breath.
Learning Objective
After completing this question, the learner should be able to:
• Identify major risks associated with estrogen-containing
contraceptives.
• Recognize smoking as a contraindication concern.
• Educate patients regarding thromboembolism warning
signs.
Medication Safety Focus
Contraindication
Question 2
Clinical Scenario
A 68-year-old male with benign prostatic hyperplasia (BPH) is
prescribed tamsulosin. The nurse is providing discharge
teaching.
Question Stem
Which instruction should the nurse include?
Genitourinary System Exam Questions and
Answers |
20 NGN-Style Practice MCQs with Rationales |
ATI Pharmacology Made Easy Review 2026
Question 1
Clinical Scenario
A 24-year-old female is prescribed a combined oral
contraceptive containing ethinyl estradiol and norethindrone.
During a follow-up visit, she reports smoking one pack of
cigarettes daily and asks about medication safety.
Question Stem
Which information is most important for the nurse to provide?
A. Smoking increases the effectiveness of oral contraceptives.
B. Smoking while taking combined oral contraceptives increases
the risk of thromboembolic events.
C. Oral contraceptives should be discontinued during
,menstruation.
D. Combined oral contraceptives prevent all sexually
transmitted infections.
Correct Answer
B. Smoking while taking combined oral contraceptives
increases the risk of thromboembolic events.
Detailed Rationale
Combined oral contraceptives contain estrogen, which
increases coagulation factors and the risk of venous
thromboembolism, stroke, and myocardial infarction. Smoking
further increases cardiovascular and thrombotic risk,
particularly in women older than 35 years, but smoking is a
concern at any age. Patient education regarding smoking
cessation is a priority safety intervention.
Option A is incorrect because smoking does not increase
contraceptive effectiveness. Option C is incorrect because oral
contraceptives should be taken consistently according to the
prescribed schedule, including during menstruation. Option D is
incorrect because hormonal contraceptives do not protect
against sexually transmitted infections; barrier methods are
necessary for STI prevention.
The nurse should assess additional risk factors such as
hypertension, obesity, migraines with aura, and history of
, thromboembolic disease. Teaching should emphasize
recognizing symptoms of thrombosis such as unilateral leg
swelling, chest pain, and sudden shortness of breath.
Learning Objective
After completing this question, the learner should be able to:
• Identify major risks associated with estrogen-containing
contraceptives.
• Recognize smoking as a contraindication concern.
• Educate patients regarding thromboembolism warning
signs.
Medication Safety Focus
Contraindication
Question 2
Clinical Scenario
A 68-year-old male with benign prostatic hyperplasia (BPH) is
prescribed tamsulosin. The nurse is providing discharge
teaching.
Question Stem
Which instruction should the nurse include?
