Comprehensive Osteopathic Medical
Licensing Exam Practice Questions And
Correct Answers (Verified Answers) Plus
Rationales 2026 Q&A | Instant
Download Pdf
1. A 65-year-old man presents with exertional chest pain relieved by rest.
Which is the most likely diagnosis?
A. Stable angina
B. Myocardial infarction
C. Pericarditis
D. GERD
E. Aortic dissection
Correct answer: A. Stable angina
Rationale: Stable angina presents as predictable chest pain on exertion
relieved by rest due to transient myocardial ischemia.
, 2. A 22-year-old woman presents with tremor, weight loss, and heat
intolerance. Labs show low TSH and elevated T4. Diagnosis?
A. Hypothyroidism
B. Graves disease
C. Hashimoto thyroiditis
D. Thyroid cancer
E. Subacute thyroiditis
Correct answer: B. Graves disease
Rationale: Graves disease is an autoimmune hyperthyroidism characterized
by suppressed TSH and elevated thyroid hormones.
3. Which valve is most commonly affected in rheumatic heart disease?
A. Aortic
B. Pulmonary
C. Tricuspid
D. Mitral
E. Pulmonic
Correct answer: D. Mitral
Rationale: The mitral valve is most commonly involved in rheumatic heart
disease due to immune-mediated damage.
4. A patient with COPD is most likely to have which ABG pattern?
A. Respiratory alkalosis
, B. Metabolic alkalosis
C. Respiratory acidosis
D. Metabolic acidosis
E. Normal ABG
Correct answer: C. Respiratory acidosis
Rationale: COPD leads to CO₂ retention resulting in chronic respiratory
acidosis.
5. Which organism causes peptic ulcers associated with H. pylori
infection?
A. E. coli
B. H. influenzae
C. Helicobacter pylori
D. Staphylococcus aureus
E. Streptococcus pyogenes
Correct answer: C. Helicobacter pylori
Rationale: H. pylori damages gastric mucosa leading to ulcer formation.
6. A 30-year-old man presents with fever, headache, and stiff neck. Most
likely diagnosis?
A. Migraine
B. Meningitis
C. Stroke
, D. Brain tumor
E. Sinusitis
Correct answer: B. Meningitis
Rationale: Classic triad includes fever, neck stiffness, and altered mental
status.
7. Which electrolyte abnormality is seen in Addison disease?
A. Hypernatremia
B. Hypokalemia
C. Hyperkalemia
D. Hypercalcemia
E. Hypochloremia
Correct answer: C. Hyperkalemia
Rationale: Aldosterone deficiency causes potassium retention.
8. What is the primary neurotransmitter at the neuromuscular junction?
A. Dopamine
B. Serotonin
C. Acetylcholine
D. GABA
E. Norepinephrine
Correct answer: C. Acetylcholine
Rationale: Acetylcholine mediates skeletal muscle contraction at the NMJ.
Licensing Exam Practice Questions And
Correct Answers (Verified Answers) Plus
Rationales 2026 Q&A | Instant
Download Pdf
1. A 65-year-old man presents with exertional chest pain relieved by rest.
Which is the most likely diagnosis?
A. Stable angina
B. Myocardial infarction
C. Pericarditis
D. GERD
E. Aortic dissection
Correct answer: A. Stable angina
Rationale: Stable angina presents as predictable chest pain on exertion
relieved by rest due to transient myocardial ischemia.
, 2. A 22-year-old woman presents with tremor, weight loss, and heat
intolerance. Labs show low TSH and elevated T4. Diagnosis?
A. Hypothyroidism
B. Graves disease
C. Hashimoto thyroiditis
D. Thyroid cancer
E. Subacute thyroiditis
Correct answer: B. Graves disease
Rationale: Graves disease is an autoimmune hyperthyroidism characterized
by suppressed TSH and elevated thyroid hormones.
3. Which valve is most commonly affected in rheumatic heart disease?
A. Aortic
B. Pulmonary
C. Tricuspid
D. Mitral
E. Pulmonic
Correct answer: D. Mitral
Rationale: The mitral valve is most commonly involved in rheumatic heart
disease due to immune-mediated damage.
4. A patient with COPD is most likely to have which ABG pattern?
A. Respiratory alkalosis
, B. Metabolic alkalosis
C. Respiratory acidosis
D. Metabolic acidosis
E. Normal ABG
Correct answer: C. Respiratory acidosis
Rationale: COPD leads to CO₂ retention resulting in chronic respiratory
acidosis.
5. Which organism causes peptic ulcers associated with H. pylori
infection?
A. E. coli
B. H. influenzae
C. Helicobacter pylori
D. Staphylococcus aureus
E. Streptococcus pyogenes
Correct answer: C. Helicobacter pylori
Rationale: H. pylori damages gastric mucosa leading to ulcer formation.
6. A 30-year-old man presents with fever, headache, and stiff neck. Most
likely diagnosis?
A. Migraine
B. Meningitis
C. Stroke
, D. Brain tumor
E. Sinusitis
Correct answer: B. Meningitis
Rationale: Classic triad includes fever, neck stiffness, and altered mental
status.
7. Which electrolyte abnormality is seen in Addison disease?
A. Hypernatremia
B. Hypokalemia
C. Hyperkalemia
D. Hypercalcemia
E. Hypochloremia
Correct answer: C. Hyperkalemia
Rationale: Aldosterone deficiency causes potassium retention.
8. What is the primary neurotransmitter at the neuromuscular junction?
A. Dopamine
B. Serotonin
C. Acetylcholine
D. GABA
E. Norepinephrine
Correct answer: C. Acetylcholine
Rationale: Acetylcholine mediates skeletal muscle contraction at the NMJ.
