NU 641 Exam 3 Questions with Correct
Answers
drugs used for parkinson's
dopaminergic
anticholinergic
levodopa - how is it used and why combined with carbidopa
how used: as dopamine replacement in parkinsons undergoes conversion to DA in brain and
activates DA receptors.
why: blocks destruction of levodopa in periphery to decrease amount of decarboxylation so
more drug can enter CNS and increase dopamine synthesis (ties up vitamin b 6)
patient education levodopa
avoid high protein meals delays drug
can have on/off period - tell MD
N/V common take with fruits/veggies
monitor cardiac s/s and renal/liver function
psychosis see MD
what can't you combined levodopa with?
, antipsychotics decrease effectiveness
MAO increase toxicity
pramipexole - what is it used for?
- parkinsons as dopamine agonist in early stages of PD to improve motor function and
combined with levodopa in advance stages to reduce fluctuations of motor control
- restless leg syndrome
SE pramipexole
nausea, dizziness, somulence, insomnia, constipation, hallucinations, SLEEP ATTACKS &
IMPULSE CONTROL DISORDERS (screen for this)
has less sleep attacks than other agents
what drug increases pramipexole levels?
cimetidine
what drug is used to treat n/v in apomorphine
trimethobenzamide (Tigan) 3 days before taking. Cannot combine with other antimetics risk
for postural hypotension and decrease effectiveness of drug.
what is apomorphine used for?
acute hypomobility during off episodes in advance PD given by injection
apomorphine SE
Answers
drugs used for parkinson's
dopaminergic
anticholinergic
levodopa - how is it used and why combined with carbidopa
how used: as dopamine replacement in parkinsons undergoes conversion to DA in brain and
activates DA receptors.
why: blocks destruction of levodopa in periphery to decrease amount of decarboxylation so
more drug can enter CNS and increase dopamine synthesis (ties up vitamin b 6)
patient education levodopa
avoid high protein meals delays drug
can have on/off period - tell MD
N/V common take with fruits/veggies
monitor cardiac s/s and renal/liver function
psychosis see MD
what can't you combined levodopa with?
, antipsychotics decrease effectiveness
MAO increase toxicity
pramipexole - what is it used for?
- parkinsons as dopamine agonist in early stages of PD to improve motor function and
combined with levodopa in advance stages to reduce fluctuations of motor control
- restless leg syndrome
SE pramipexole
nausea, dizziness, somulence, insomnia, constipation, hallucinations, SLEEP ATTACKS &
IMPULSE CONTROL DISORDERS (screen for this)
has less sleep attacks than other agents
what drug increases pramipexole levels?
cimetidine
what drug is used to treat n/v in apomorphine
trimethobenzamide (Tigan) 3 days before taking. Cannot combine with other antimetics risk
for postural hypotension and decrease effectiveness of drug.
what is apomorphine used for?
acute hypomobility during off episodes in advance PD given by injection
apomorphine SE
