CSB601 Practice Questions with Correct
Answers
Depression (First-line)
SSRIs
Bipolar Disorder (First-line)
Lithium
Anxiety (First-line)
SSRIs
Hypertension (First-line)
ACEi/ARB/CCB/Thiazide
Dyslipidaemia (First-line)
Statins
Heart Failure (First-line)
ACEi/ARB/ARNI + Beta blocker + MRA + SGLT2i
AF Stroke Prevention (First-line)
DOACs
Angina Attack (First-line)
GTN
T1DM (First-line)
Insulin
,T2DM (First-line)
Metformin
Asthma Reliever (First-line)
Salbutamol
Asthma Preventer (First-line)
ICS
Smoking Cessation (First-line)
NRT or Varenicline
Osteoarthritis (First-line)
Exercise + topical NSAIDs
Rheumatoid Arthritis (First-line)
Methotrexate
Allergy (First-line)
Cetirizine/Loratadine
Anaphylaxis (First-line)
IM Adrenaline
Arrhythmias (First-line)
Beta-blockers
Benzodiazepines
MOA: Enhance GABA-A receptor activity for increased CNS inhibition
, MAOIs (monoamine oxidase inhibitors)
MOA: Inhibit MAO-A + MAO-B from breaking down 5HT, NA, DA and adrenaline
Last-line
Pharmacokinetics
What the body does to the drug
ADME (absorption, distribution, metabolism, excretion)
Pharmacodynamics
What the drug does to the body
SSRIs (selective serotonin reuptake inhibitors)
MOA: Selectively inhibits the presynaptic reuptake of serotonin (5-HT)
AEs: GI upset, nausea, diarrhoea, insomnia, sexual dysfunction
e.g. citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine
SNRIs (serotonin-norepinephrine reuptake inhibitors)
MOA: Block presynaptic reuptake of 5-HT + NA
e.g. renlafaxine, desvenlafaxine, duloxetine
ACEi
MOA: Block conversion of Angiotensin I to Angiotensin II
Promote vasodilation, lowered arterial pressure, lowered aldosterone = less sodium + fluid
retention
AEs: hypotension, cough, hyperkalaemia, headache, dizziness, fatigue, nausea
-pril
e.g. perindopril
Answers
Depression (First-line)
SSRIs
Bipolar Disorder (First-line)
Lithium
Anxiety (First-line)
SSRIs
Hypertension (First-line)
ACEi/ARB/CCB/Thiazide
Dyslipidaemia (First-line)
Statins
Heart Failure (First-line)
ACEi/ARB/ARNI + Beta blocker + MRA + SGLT2i
AF Stroke Prevention (First-line)
DOACs
Angina Attack (First-line)
GTN
T1DM (First-line)
Insulin
,T2DM (First-line)
Metformin
Asthma Reliever (First-line)
Salbutamol
Asthma Preventer (First-line)
ICS
Smoking Cessation (First-line)
NRT or Varenicline
Osteoarthritis (First-line)
Exercise + topical NSAIDs
Rheumatoid Arthritis (First-line)
Methotrexate
Allergy (First-line)
Cetirizine/Loratadine
Anaphylaxis (First-line)
IM Adrenaline
Arrhythmias (First-line)
Beta-blockers
Benzodiazepines
MOA: Enhance GABA-A receptor activity for increased CNS inhibition
, MAOIs (monoamine oxidase inhibitors)
MOA: Inhibit MAO-A + MAO-B from breaking down 5HT, NA, DA and adrenaline
Last-line
Pharmacokinetics
What the body does to the drug
ADME (absorption, distribution, metabolism, excretion)
Pharmacodynamics
What the drug does to the body
SSRIs (selective serotonin reuptake inhibitors)
MOA: Selectively inhibits the presynaptic reuptake of serotonin (5-HT)
AEs: GI upset, nausea, diarrhoea, insomnia, sexual dysfunction
e.g. citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine
SNRIs (serotonin-norepinephrine reuptake inhibitors)
MOA: Block presynaptic reuptake of 5-HT + NA
e.g. renlafaxine, desvenlafaxine, duloxetine
ACEi
MOA: Block conversion of Angiotensin I to Angiotensin II
Promote vasodilation, lowered arterial pressure, lowered aldosterone = less sodium + fluid
retention
AEs: hypotension, cough, hyperkalaemia, headache, dizziness, fatigue, nausea
-pril
e.g. perindopril
