CPIA EXAM PREP NEWEST
2026/2027: Complete Study Guide
with Practice Questions and Answers
[Verified Explanations]
Key Legislation and Historical Milestones
Q: What year did Congress pass the Laboratory Animal
Welfare Act?
• A. 1971
• B. 1963
• C. 1966
• D. 1979
Answer: C. 1966
Explanation: The Laboratory Animal Welfare Act was passed by
Congress in 1966, establishing the foundation for federal
regulation of animal care and use in research.
Q: In what year was the Animal Care Panel established?
• A. 1950
• B. 1976
• C. 1963
• D. 1985
Answer: A. 1950
,Explanation: The Animal Care Panel, which later became the
American Association for Laboratory Animal Science (AALAS),
was established in 1950.
Q: In what year was the first Public Health Service Policy on
Humane Care and Use of Laboratory Animals established?
• A. 1971
• B. 1973
• C. 1974
• D. 1979
Answer: B. 1973
Q: In what year was the first edition of the Guide for the
Care and Use of Laboratory Animals developed?
• A. 1950
• B. 1963
• C. 1965
• D. 1967
Answer: B. 1963
Q: Public Responsibility in Medicine and Research
(PRIM&R) was established in which year?
• A. 1973
, • B. 1974
• C. 1979
• D. 1982
Answer: A. 1973
Q: True/False: The Animal Care Panel changed its name to
the American Association for Laboratory Animal Science
(AALAS) in 1967.
Answer: True
Q: True/False: In 1963, the incorporation of the American
Association for the Accreditation of Laboratory Animal Care
(AAALAC) was established.
Answer: False - AAALAC was incorporated in 1965.
U.S. Government Principles
Q: Which U.S. Government Principle states that the care and
use of animals should be in accordance with the Animal
Welfare Act?
• A. U.S. Government Principle I
• B. U.S. Government Principle II
• C. U.S. Government Principle III
• D. U.S. Government Principle IV
Answer: A. U.S. Government Principle I
, Q: True/False: U.S. Government Principle II states that
procedures involving animals should be designed and
performed with due consideration of their relevance to
human or animal health, the advancement of knowledge, or
the good of society.
Answer: True
Q: U.S. Government Principles on the Use of Animals in
Research state that:
• A. Relief of pain should be provided for vertebrate animals
except for birds, mice and rats
• B. Animals will show evidence of pain if a procedure
causes them pain
• C. Pain is perceived differently by animals than by humans
• D. Procedures that are painful to humans should be
assumed to cause pain in animals unless there is evidence
to the contrary
Answer: D. Procedures that are painful to humans should
be assumed to cause pain in animals unless there is
evidence to the contrary.
Health Research Extension Act of 1985
Q: The Health Research Extension Act of 1985 directs ______
to establish guidelines for the proper care and treatment of
2026/2027: Complete Study Guide
with Practice Questions and Answers
[Verified Explanations]
Key Legislation and Historical Milestones
Q: What year did Congress pass the Laboratory Animal
Welfare Act?
• A. 1971
• B. 1963
• C. 1966
• D. 1979
Answer: C. 1966
Explanation: The Laboratory Animal Welfare Act was passed by
Congress in 1966, establishing the foundation for federal
regulation of animal care and use in research.
Q: In what year was the Animal Care Panel established?
• A. 1950
• B. 1976
• C. 1963
• D. 1985
Answer: A. 1950
,Explanation: The Animal Care Panel, which later became the
American Association for Laboratory Animal Science (AALAS),
was established in 1950.
Q: In what year was the first Public Health Service Policy on
Humane Care and Use of Laboratory Animals established?
• A. 1971
• B. 1973
• C. 1974
• D. 1979
Answer: B. 1973
Q: In what year was the first edition of the Guide for the
Care and Use of Laboratory Animals developed?
• A. 1950
• B. 1963
• C. 1965
• D. 1967
Answer: B. 1963
Q: Public Responsibility in Medicine and Research
(PRIM&R) was established in which year?
• A. 1973
, • B. 1974
• C. 1979
• D. 1982
Answer: A. 1973
Q: True/False: The Animal Care Panel changed its name to
the American Association for Laboratory Animal Science
(AALAS) in 1967.
Answer: True
Q: True/False: In 1963, the incorporation of the American
Association for the Accreditation of Laboratory Animal Care
(AAALAC) was established.
Answer: False - AAALAC was incorporated in 1965.
U.S. Government Principles
Q: Which U.S. Government Principle states that the care and
use of animals should be in accordance with the Animal
Welfare Act?
• A. U.S. Government Principle I
• B. U.S. Government Principle II
• C. U.S. Government Principle III
• D. U.S. Government Principle IV
Answer: A. U.S. Government Principle I
, Q: True/False: U.S. Government Principle II states that
procedures involving animals should be designed and
performed with due consideration of their relevance to
human or animal health, the advancement of knowledge, or
the good of society.
Answer: True
Q: U.S. Government Principles on the Use of Animals in
Research state that:
• A. Relief of pain should be provided for vertebrate animals
except for birds, mice and rats
• B. Animals will show evidence of pain if a procedure
causes them pain
• C. Pain is perceived differently by animals than by humans
• D. Procedures that are painful to humans should be
assumed to cause pain in animals unless there is evidence
to the contrary
Answer: D. Procedures that are painful to humans should
be assumed to cause pain in animals unless there is
evidence to the contrary.
Health Research Extension Act of 1985
Q: The Health Research Extension Act of 1985 directs ______
to establish guidelines for the proper care and treatment of
