LMR GEORGETTE’S LATEST EXAM TEST 2026/2027
QUESTIONS AND SOLUTIONS RATED A+
✔✔Neuroleptic Malignant Syndrome caused by which med - ✔✔antipsychotics
✔✔Symptoms of NMS - ✔✔muscular rigidity, mutism, hyperthermia, tachycardia,
diaphoresis, elevated CPK/WBCS/LFTs
✔✔NMS Treatment - ✔✔D/c offending agent, Bromocriptine (dopamine agonist),
Dantrolene (muscle relaxant)
✔✔Serotonin Syndrome symptoms - ✔✔hyperreflexia, myoclonic jerks,
sweating/shivering, rapid heart rate
✔✔Neurological defects associated with Schizophrenia - ✔✔Enlarged ventricles,
cerebral cortex atrophy, decreased cerebral blood flow, hippocampal and amygdala
reduction
✔✔ACT (Assertive Community Treatment) - ✔✔holistic approach of services provided
in community setting
✔✔Tangentiality - ✔✔moving from thought to thought that may never get to the point
✔✔Circumstantiality - ✔✔provide unnecessary detail but eventually get to the point
✔✔Mesolimbic pathway - ✔✔high dopamineleads to positive psychotic symptoms
antagonism of D2 receptors in this pathway can help treat positive symptoms
affects ventral tegmental area
✔✔Mesocortical pathway - ✔✔decreased dopamine leads to both positive and negative
symptoms
✔✔Nigrostriatal pathway - ✔✔mediates motor movements
blockade of dopamine can lead to EPS
✔✔EPS treatment - ✔✔Benztropine (Cogentin)
✔✔Tuberofundibular pathway - ✔✔blockade of D2 receptors can lead to
hyperprolactinemia
✔✔What enzyme is nicotene metabolized by? - ✔✔CYP2A6
✔✔What enzyme is clozapine metabolized by? - ✔✔CYP1A2
, ✔✔What do inducers do? - ✔✔Decrease serum level of other drugs that are substrates
of that enzyme, causing subtherapeutic levels
✔✔What do inhibitors do? - ✔✔can cause higher serum level, potentially leading to
toxic levels
✔✔Bipolar disorder treatment - ✔✔Lithium: neuroprotective
Olanzapine with Prozac; Latuda, or Seroquel for bipolar depression
✔✔Borderline personality treatment - ✔✔Lithium for irritability and self harm, Depakote
for mood lability, SSRIs for depression and anxiety
✔✔ADHD brain issues - ✔✔dorsolateral prefrontal cortex and orbitofrontal cortex
abnormalities in the RAS
✔✔What neurotransmitters are affected in ADHD - ✔✔dopamine and norepinephrine
✔✔Signs of stimulant abuse - ✔✔insomnia, tremors, heart palpitations
✔✔OCD neurotransmitters - ✔✔high glutamate, low serotonin
✔✔Dementia neurotransmitters - ✔✔decreased acetylcholine and norepinephrine
✔✔Dementia brain effects - ✔✔diffuse cerebral atrophy and enlarged ventricles
✔✔Subcortical vs cortical dementia - ✔✔Subcortical: motor symptoms
Cortical: language and memory impairments
✔✔Parkinsons dementia treatment - ✔✔donezapil, galantamine
✔✔Amygdala regulates - ✔✔aggression, fear, anxiety, emotions
✔✔Hypothalamus regulates - ✔✔appetite, circadian rhythm, hormones
✔✔Hippocampus regulates - ✔✔memory, stress
✔✔Addiction parts of the brain - ✔✔nucleus accumbens
hippocampus
amygdala
prefrontal cortex
✔✔Depression scales - ✔✔PHQ9, HAM D, Beck, MADRS
✔✔Moderate PHQ9 - ✔✔10-14
QUESTIONS AND SOLUTIONS RATED A+
✔✔Neuroleptic Malignant Syndrome caused by which med - ✔✔antipsychotics
✔✔Symptoms of NMS - ✔✔muscular rigidity, mutism, hyperthermia, tachycardia,
diaphoresis, elevated CPK/WBCS/LFTs
✔✔NMS Treatment - ✔✔D/c offending agent, Bromocriptine (dopamine agonist),
Dantrolene (muscle relaxant)
✔✔Serotonin Syndrome symptoms - ✔✔hyperreflexia, myoclonic jerks,
sweating/shivering, rapid heart rate
✔✔Neurological defects associated with Schizophrenia - ✔✔Enlarged ventricles,
cerebral cortex atrophy, decreased cerebral blood flow, hippocampal and amygdala
reduction
✔✔ACT (Assertive Community Treatment) - ✔✔holistic approach of services provided
in community setting
✔✔Tangentiality - ✔✔moving from thought to thought that may never get to the point
✔✔Circumstantiality - ✔✔provide unnecessary detail but eventually get to the point
✔✔Mesolimbic pathway - ✔✔high dopamineleads to positive psychotic symptoms
antagonism of D2 receptors in this pathway can help treat positive symptoms
affects ventral tegmental area
✔✔Mesocortical pathway - ✔✔decreased dopamine leads to both positive and negative
symptoms
✔✔Nigrostriatal pathway - ✔✔mediates motor movements
blockade of dopamine can lead to EPS
✔✔EPS treatment - ✔✔Benztropine (Cogentin)
✔✔Tuberofundibular pathway - ✔✔blockade of D2 receptors can lead to
hyperprolactinemia
✔✔What enzyme is nicotene metabolized by? - ✔✔CYP2A6
✔✔What enzyme is clozapine metabolized by? - ✔✔CYP1A2
, ✔✔What do inducers do? - ✔✔Decrease serum level of other drugs that are substrates
of that enzyme, causing subtherapeutic levels
✔✔What do inhibitors do? - ✔✔can cause higher serum level, potentially leading to
toxic levels
✔✔Bipolar disorder treatment - ✔✔Lithium: neuroprotective
Olanzapine with Prozac; Latuda, or Seroquel for bipolar depression
✔✔Borderline personality treatment - ✔✔Lithium for irritability and self harm, Depakote
for mood lability, SSRIs for depression and anxiety
✔✔ADHD brain issues - ✔✔dorsolateral prefrontal cortex and orbitofrontal cortex
abnormalities in the RAS
✔✔What neurotransmitters are affected in ADHD - ✔✔dopamine and norepinephrine
✔✔Signs of stimulant abuse - ✔✔insomnia, tremors, heart palpitations
✔✔OCD neurotransmitters - ✔✔high glutamate, low serotonin
✔✔Dementia neurotransmitters - ✔✔decreased acetylcholine and norepinephrine
✔✔Dementia brain effects - ✔✔diffuse cerebral atrophy and enlarged ventricles
✔✔Subcortical vs cortical dementia - ✔✔Subcortical: motor symptoms
Cortical: language and memory impairments
✔✔Parkinsons dementia treatment - ✔✔donezapil, galantamine
✔✔Amygdala regulates - ✔✔aggression, fear, anxiety, emotions
✔✔Hypothalamus regulates - ✔✔appetite, circadian rhythm, hormones
✔✔Hippocampus regulates - ✔✔memory, stress
✔✔Addiction parts of the brain - ✔✔nucleus accumbens
hippocampus
amygdala
prefrontal cortex
✔✔Depression scales - ✔✔PHQ9, HAM D, Beck, MADRS
✔✔Moderate PHQ9 - ✔✔10-14
