Multistate Pharmacy Jurisprudence
Examination (MPJE®) Comprehensive Practice
Question Bank – Version 2.0 a well detailed
exam 2025/2026 graded A+ upgraded !!!
Advanced-Level Multiple-Choice Questions
Covering Federal and State Pharmacy Law,
Controlled Substances Regulation, Patient
Safety, and Professional Practice Standards
Domain 1: Pharmacy and Pharmacist Practice
Question 1
A pharmacist licensed in State A has been practicing for 15 years and wishes to obtain licensure
in State B. Which of the following is TRUE regarding the licensure process?
A. State B must accept State A's license through reciprocity within 30 days
B. The pharmacist must apply for licensure in State B and meet all requirements
C. The pharmacist may practice in State B using State A license for 90 days
D. The pharmacist's NABP e-profile automatically transfers the license to State B
Correct Answer: B
Rationale: Pharmacy practice is regulated at the state level, and each state has its own licensure
requirements. A pharmacist must be licensed in the state where they are practicing. Reciprocity
(licensure transfer) is not automatic; the pharmacist must apply to the state board of pharmacy
in State B and meet all requirements, which typically include passing the MPJE for that
jurisdiction.
,Question 2
Which DEA form is used by a pharmacy to order Schedule II controlled substances from a
supplier?
A. DEA Form 41
B. DEA Form 106
C. DEA Form 222
D. DEA Form 224
Correct Answer: C
Rationale: DEA Form 222 is the official order form used to purchase Schedule II controlled
substances. DEA Form 41 is used for disposal/destruction of controlled substances, DEA Form
106 for reporting theft or loss, and DEA Form 224 for retail pharmacy registration.
Question 3
Under the Poison Prevention Packaging Act (PPPA), which of the following medications is
EXEMPT from child-resistant packaging requirements?
A. Oral contraceptives in unit-dose packaging
B. Sublingual nitroglycerin
C. Erythromycin ethylsuccinate granules for oral suspension
D. Isosorbide dinitrate tablets
Correct Answer: B
Rationale: Sublingual nitroglycerin is exempt from child-resistant packaging requirements
because patients need rapid access in emergency situations. Other exemptions include
sublingual isosorbide dinitrate (not regular tablets), certain powdered forms, and medications
prescribed for specific conditions where child-resistant packaging would impede emergency
use.
Question 4
A pharmacy technician may perform which of the following tasks under direct pharmacist
supervision?
A. Receive a verbal prescription from a prescriber
B. Counsel a patient on the use of a new medication
C. Count, pour, and package medications for dispensing
D. Perform the final verification of a filled prescription
,Correct Answer: C
Rationale: Pharmacy technicians may perform technical tasks such as counting, pouring, and
packaging medications under pharmacist supervision. Receiving new prescriptions, patient
counseling, and final verification are functions that require pharmacist involvement.
Question 5
Which federal law established the requirement for pharmacists to perform prospective drug
utilization review (ProDUR) and offer counseling to Medicaid patients?
A. The Food, Drug, and Cosmetic Act
B. The Controlled Substances Act
C. The Omnibus Budget Reconciliation Act of 1990 (OBRA '90)
D. The Health Insurance Portability and Accountability Act
Correct Answer: C
Rationale: OBRA '90 mandated that pharmacists perform prospective drug utilization review
and offer counseling to Medicaid patients as a condition for states to receive federal funding.
Most states have extended these requirements to all patients.
Question 6
A pharmacist's DEA registration for a retail pharmacy (Form 224) must be renewed every:
A. 1 year
B. 2 years
C. 3 years
D. 5 years
Correct Answer: C
Rationale: DEA registrations for retail pharmacies (Form 224) must be renewed every three
years. This applies to most pharmacy practice registrations. Manufacturers and distributors
(Form 225) also renew every three years.
Question 7
A pharmacist receives a prescription for a Schedule II controlled substance. The prescription is
dated 45 days ago. Under federal law, the pharmacist should:
A. Fill the prescription as written
B. Call the prescriber to verify continued validity
, C. Refuse to fill the prescription
D. Fill the prescription only if the patient has been on the medication continuously
Correct Answer: A
Rationale: Federal law does not specify an expiration date for Schedule II prescriptions;
however, most states impose a time limit (typically 6 months). A 45-day-old prescription is
generally still valid under federal law, but the pharmacist must check state-specific
requirements. The question tests knowledge that federal law does not set a specific expiration
for Schedule II.
Question 8
Which of the following is required on all prescription labels for dispensed medications under
federal law?
A. The patient's diagnosis
B. The prescriber's DEA number
C. The name and address of the dispensing pharmacy
D. The NDC number of the dispensed product
Correct Answer: C
Rationale: Prescription labels must include the name, address, and telephone number of the
dispensing pharmacy. Other required elements include the patient's name, the prescriber's
name, the drug name and strength, directions for use, the date of dispensing, and the
prescription number.
Question 9
A pharmacist who is unable to practice with reasonable skill and safety due to substance abuse
should:
A. Continue practicing until a complaint is filed
B. Report themselves to the state board of pharmacy or impaired pharmacist program
C. Only seek treatment if mandated by the board
D. Designate a colleague to supervise all dispensing
Correct Answer: B
Rationale: Pharmacists have an obligation to report their own inability to practice safely and to
participate in programs addressing such issues. Most state boards have impaired pharmacist
programs that provide confidential treatment and monitoring. Continuing to practice while
impaired constitutes grounds for disciplinary action.
Examination (MPJE®) Comprehensive Practice
Question Bank – Version 2.0 a well detailed
exam 2025/2026 graded A+ upgraded !!!
Advanced-Level Multiple-Choice Questions
Covering Federal and State Pharmacy Law,
Controlled Substances Regulation, Patient
Safety, and Professional Practice Standards
Domain 1: Pharmacy and Pharmacist Practice
Question 1
A pharmacist licensed in State A has been practicing for 15 years and wishes to obtain licensure
in State B. Which of the following is TRUE regarding the licensure process?
A. State B must accept State A's license through reciprocity within 30 days
B. The pharmacist must apply for licensure in State B and meet all requirements
C. The pharmacist may practice in State B using State A license for 90 days
D. The pharmacist's NABP e-profile automatically transfers the license to State B
Correct Answer: B
Rationale: Pharmacy practice is regulated at the state level, and each state has its own licensure
requirements. A pharmacist must be licensed in the state where they are practicing. Reciprocity
(licensure transfer) is not automatic; the pharmacist must apply to the state board of pharmacy
in State B and meet all requirements, which typically include passing the MPJE for that
jurisdiction.
,Question 2
Which DEA form is used by a pharmacy to order Schedule II controlled substances from a
supplier?
A. DEA Form 41
B. DEA Form 106
C. DEA Form 222
D. DEA Form 224
Correct Answer: C
Rationale: DEA Form 222 is the official order form used to purchase Schedule II controlled
substances. DEA Form 41 is used for disposal/destruction of controlled substances, DEA Form
106 for reporting theft or loss, and DEA Form 224 for retail pharmacy registration.
Question 3
Under the Poison Prevention Packaging Act (PPPA), which of the following medications is
EXEMPT from child-resistant packaging requirements?
A. Oral contraceptives in unit-dose packaging
B. Sublingual nitroglycerin
C. Erythromycin ethylsuccinate granules for oral suspension
D. Isosorbide dinitrate tablets
Correct Answer: B
Rationale: Sublingual nitroglycerin is exempt from child-resistant packaging requirements
because patients need rapid access in emergency situations. Other exemptions include
sublingual isosorbide dinitrate (not regular tablets), certain powdered forms, and medications
prescribed for specific conditions where child-resistant packaging would impede emergency
use.
Question 4
A pharmacy technician may perform which of the following tasks under direct pharmacist
supervision?
A. Receive a verbal prescription from a prescriber
B. Counsel a patient on the use of a new medication
C. Count, pour, and package medications for dispensing
D. Perform the final verification of a filled prescription
,Correct Answer: C
Rationale: Pharmacy technicians may perform technical tasks such as counting, pouring, and
packaging medications under pharmacist supervision. Receiving new prescriptions, patient
counseling, and final verification are functions that require pharmacist involvement.
Question 5
Which federal law established the requirement for pharmacists to perform prospective drug
utilization review (ProDUR) and offer counseling to Medicaid patients?
A. The Food, Drug, and Cosmetic Act
B. The Controlled Substances Act
C. The Omnibus Budget Reconciliation Act of 1990 (OBRA '90)
D. The Health Insurance Portability and Accountability Act
Correct Answer: C
Rationale: OBRA '90 mandated that pharmacists perform prospective drug utilization review
and offer counseling to Medicaid patients as a condition for states to receive federal funding.
Most states have extended these requirements to all patients.
Question 6
A pharmacist's DEA registration for a retail pharmacy (Form 224) must be renewed every:
A. 1 year
B. 2 years
C. 3 years
D. 5 years
Correct Answer: C
Rationale: DEA registrations for retail pharmacies (Form 224) must be renewed every three
years. This applies to most pharmacy practice registrations. Manufacturers and distributors
(Form 225) also renew every three years.
Question 7
A pharmacist receives a prescription for a Schedule II controlled substance. The prescription is
dated 45 days ago. Under federal law, the pharmacist should:
A. Fill the prescription as written
B. Call the prescriber to verify continued validity
, C. Refuse to fill the prescription
D. Fill the prescription only if the patient has been on the medication continuously
Correct Answer: A
Rationale: Federal law does not specify an expiration date for Schedule II prescriptions;
however, most states impose a time limit (typically 6 months). A 45-day-old prescription is
generally still valid under federal law, but the pharmacist must check state-specific
requirements. The question tests knowledge that federal law does not set a specific expiration
for Schedule II.
Question 8
Which of the following is required on all prescription labels for dispensed medications under
federal law?
A. The patient's diagnosis
B. The prescriber's DEA number
C. The name and address of the dispensing pharmacy
D. The NDC number of the dispensed product
Correct Answer: C
Rationale: Prescription labels must include the name, address, and telephone number of the
dispensing pharmacy. Other required elements include the patient's name, the prescriber's
name, the drug name and strength, directions for use, the date of dispensing, and the
prescription number.
Question 9
A pharmacist who is unable to practice with reasonable skill and safety due to substance abuse
should:
A. Continue practicing until a complaint is filed
B. Report themselves to the state board of pharmacy or impaired pharmacist program
C. Only seek treatment if mandated by the board
D. Designate a colleague to supervise all dispensing
Correct Answer: B
Rationale: Pharmacists have an obligation to report their own inability to practice safely and to
participate in programs addressing such issues. Most state boards have impaired pharmacist
programs that provide confidential treatment and monitoring. Continuing to practice while
impaired constitutes grounds for disciplinary action.
