Multistate Pharmacy Jurisprudence Examination
(MPJE®) Comprehensive Practice Question Bank a
well detailed exam 2025/2026 graded A+
upgraded !!! Advanced-Level Multiple-Choice
Questions Covering Federal and State Pharmacy
Law, Controlled Substances Regulation, Patient
Safety, and Professional Practice Standards
Domain 1: Pharmacy and Pharmacist Practice
Question 1
A pharmacist-in-charge (PIC) is responsible for all of the following EXCEPT:
A. Ensuring all pharmacy personnel are properly licensed and registered
B. Maintaining the pharmacy's DEA registration and controlled substance records
C. Personally verifying the identity of every patient before dispensing
D. Implementing policies to prevent medication errors and diversion
Correct Answer: C
Rationale: The pharmacist-in-charge bears ultimate responsibility for pharmacy operations,
personnel licensure, regulatory compliance, and controlled substance accountability. However,
the PIC is not required to personally verify the identity of every patient before dispensing—this
task may be delegated to pharmacy technicians or other personnel under appropriate
supervision. The PIC remains responsible for ensuring that appropriate verification procedures
are in place.
Question 2
Which of the following individuals is NOT required to register with the DEA?
A. A retail pharmacy dispensing controlled substances
,B. A hospital pharmacy administering controlled substances
C. A pharmacy intern handling controlled substances under supervision
D. A manufacturer of controlled substances
Correct Answer: C
Rationale: DEA registration is required for all entities that manufacture, distribute, or dispense
controlled substances. Pharmacy interns are not required to hold their own DEA registration;
they operate under the DEA registration of the supervising pharmacist or pharmacy. Retail
pharmacies, hospital pharmacies, and manufacturers must all maintain valid DEA registrations.
Question 3
A pharmacist licensed in State A receives a job offer in State B. Which statement regarding
licensure is correct?
A. The pharmacist may practice in State B immediately using State A license for 30 days
B. The pharmacist must obtain licensure in State B before practicing
C. The pharmacist may practice in State B if State B has reciprocity with State A
D. The pharmacist may practice in State B under federal license for 90 days
Correct Answer: B
Rationale: Pharmacy practice is regulated at the state level, and a pharmacist must be licensed
in the state where they are practicing. There is no automatic reciprocity; the pharmacist must
obtain licensure in State B, which may involve passing the MPJE for that jurisdiction or the
Uniform MPJE, depending on the state's requirements.
Question 4
Under federal law, which DEA form is used by a registrant to report the theft or significant loss
of controlled substances?
A. DEA Form 41
B. DEA Form 106
C. DEA Form 222
D. DEA Form 224
Correct Answer: B
Rationale: DEA Form 106 is used to report theft or significant loss of controlled substances to
the DEA. This report must be submitted within one business day of discovery. DEA Form 41 is
used for disposal/destruction requests, DEA Form 222 for ordering Schedule II controlled
substances, and DEA Form 224 for retail pharmacy registration.
,Question 5
A pharmacy technician may perform which of the following tasks without direct pharmacist
supervision?
A. Receive a new prescription over the phone
B. Affix the prescription label to the medication container
C. Count and pour medication for dispensing
D. Counsel a patient on medication use
Correct Answer: C
Rationale: Pharmacy technicians may perform technical tasks such as counting, pouring, and
packaging medications under pharmacist supervision. However, receiving new prescriptions,
affixing labels, and patient counseling are functions that generally require pharmacist
involvement. The pharmacist must provide direct and immediate supervision to technicians and
remains responsible for the accuracy of all dispensing activities.
Question 6
Which federal law established the requirement for pharmacists to offer counseling to Medicaid
patients?
A. The Food, Drug, and Cosmetic Act
B. The Controlled Substances Act
C. The Omnibus Budget Reconciliation Act of 1990 (OBRA '90)
D. The Health Insurance Portability and Accountability Act
Correct Answer: C
Rationale: OBRA '90 mandated that pharmacists offer to counsel Medicaid patients on their
medications as a condition for states to receive federal funding. Most states have extended this
requirement to all patients. The law also requires prospective drug utilization review (ProDUR)
and maintenance of patient profiles.
Question 7
A pharmacist's DEA registration must be renewed every:
A. 1 year
B. 2 years
C. 3 years
D. 5 years
, Correct Answer: C
Rationale: DEA registrations for retail pharmacies (Form 224) must be renewed every three
years. This applies to most pharmacy practice registrations. Manufacturers and distributors
(Form 225) also renew every three years.
Question 8
Which of the following is NOT a valid reason for a state board of pharmacy to discipline a
pharmacist?
A. Dispensing a controlled substance without a valid prescription
B. Failing to maintain proper records of controlled substances
C. Refusing to fill a prescription due to potential drug interaction
D. Practicing while impaired by drugs or alcohol
Correct Answer: C
Rationale: Refusing to fill a prescription due to a potential drug interaction is an appropriate
exercise of professional judgment and patient safety responsibility. Disciplinary actions are
warranted for violations such as dispensing without valid prescriptions, recordkeeping failures,
and practicing while impaired. Pharmacists have both the right and obligation to refuse to fill
prescriptions that may harm patients.
Question 9
Under the HIPAA Privacy Rule, a pharmacy may disclose protected health information (PHI)
without patient authorization for:
A. Marketing purposes
B. Sale of PHI to data brokers
C. Treatment, payment, and healthcare operations (TPO)
D. Research without IRB approval
Correct Answer: C
Rationale: The HIPAA Privacy Rule permits disclosure of PHI without patient authorization for
treatment, payment, and healthcare operations (TPO). Marketing, sale of PHI, and most
research require patient authorization. The minimum necessary standard applies to all
disclosures except treatment and patient-requested disclosures.
Question 10
What is the maximum number of pharmacy technicians a pharmacist may supervise at one time
(MPJE®) Comprehensive Practice Question Bank a
well detailed exam 2025/2026 graded A+
upgraded !!! Advanced-Level Multiple-Choice
Questions Covering Federal and State Pharmacy
Law, Controlled Substances Regulation, Patient
Safety, and Professional Practice Standards
Domain 1: Pharmacy and Pharmacist Practice
Question 1
A pharmacist-in-charge (PIC) is responsible for all of the following EXCEPT:
A. Ensuring all pharmacy personnel are properly licensed and registered
B. Maintaining the pharmacy's DEA registration and controlled substance records
C. Personally verifying the identity of every patient before dispensing
D. Implementing policies to prevent medication errors and diversion
Correct Answer: C
Rationale: The pharmacist-in-charge bears ultimate responsibility for pharmacy operations,
personnel licensure, regulatory compliance, and controlled substance accountability. However,
the PIC is not required to personally verify the identity of every patient before dispensing—this
task may be delegated to pharmacy technicians or other personnel under appropriate
supervision. The PIC remains responsible for ensuring that appropriate verification procedures
are in place.
Question 2
Which of the following individuals is NOT required to register with the DEA?
A. A retail pharmacy dispensing controlled substances
,B. A hospital pharmacy administering controlled substances
C. A pharmacy intern handling controlled substances under supervision
D. A manufacturer of controlled substances
Correct Answer: C
Rationale: DEA registration is required for all entities that manufacture, distribute, or dispense
controlled substances. Pharmacy interns are not required to hold their own DEA registration;
they operate under the DEA registration of the supervising pharmacist or pharmacy. Retail
pharmacies, hospital pharmacies, and manufacturers must all maintain valid DEA registrations.
Question 3
A pharmacist licensed in State A receives a job offer in State B. Which statement regarding
licensure is correct?
A. The pharmacist may practice in State B immediately using State A license for 30 days
B. The pharmacist must obtain licensure in State B before practicing
C. The pharmacist may practice in State B if State B has reciprocity with State A
D. The pharmacist may practice in State B under federal license for 90 days
Correct Answer: B
Rationale: Pharmacy practice is regulated at the state level, and a pharmacist must be licensed
in the state where they are practicing. There is no automatic reciprocity; the pharmacist must
obtain licensure in State B, which may involve passing the MPJE for that jurisdiction or the
Uniform MPJE, depending on the state's requirements.
Question 4
Under federal law, which DEA form is used by a registrant to report the theft or significant loss
of controlled substances?
A. DEA Form 41
B. DEA Form 106
C. DEA Form 222
D. DEA Form 224
Correct Answer: B
Rationale: DEA Form 106 is used to report theft or significant loss of controlled substances to
the DEA. This report must be submitted within one business day of discovery. DEA Form 41 is
used for disposal/destruction requests, DEA Form 222 for ordering Schedule II controlled
substances, and DEA Form 224 for retail pharmacy registration.
,Question 5
A pharmacy technician may perform which of the following tasks without direct pharmacist
supervision?
A. Receive a new prescription over the phone
B. Affix the prescription label to the medication container
C. Count and pour medication for dispensing
D. Counsel a patient on medication use
Correct Answer: C
Rationale: Pharmacy technicians may perform technical tasks such as counting, pouring, and
packaging medications under pharmacist supervision. However, receiving new prescriptions,
affixing labels, and patient counseling are functions that generally require pharmacist
involvement. The pharmacist must provide direct and immediate supervision to technicians and
remains responsible for the accuracy of all dispensing activities.
Question 6
Which federal law established the requirement for pharmacists to offer counseling to Medicaid
patients?
A. The Food, Drug, and Cosmetic Act
B. The Controlled Substances Act
C. The Omnibus Budget Reconciliation Act of 1990 (OBRA '90)
D. The Health Insurance Portability and Accountability Act
Correct Answer: C
Rationale: OBRA '90 mandated that pharmacists offer to counsel Medicaid patients on their
medications as a condition for states to receive federal funding. Most states have extended this
requirement to all patients. The law also requires prospective drug utilization review (ProDUR)
and maintenance of patient profiles.
Question 7
A pharmacist's DEA registration must be renewed every:
A. 1 year
B. 2 years
C. 3 years
D. 5 years
, Correct Answer: C
Rationale: DEA registrations for retail pharmacies (Form 224) must be renewed every three
years. This applies to most pharmacy practice registrations. Manufacturers and distributors
(Form 225) also renew every three years.
Question 8
Which of the following is NOT a valid reason for a state board of pharmacy to discipline a
pharmacist?
A. Dispensing a controlled substance without a valid prescription
B. Failing to maintain proper records of controlled substances
C. Refusing to fill a prescription due to potential drug interaction
D. Practicing while impaired by drugs or alcohol
Correct Answer: C
Rationale: Refusing to fill a prescription due to a potential drug interaction is an appropriate
exercise of professional judgment and patient safety responsibility. Disciplinary actions are
warranted for violations such as dispensing without valid prescriptions, recordkeeping failures,
and practicing while impaired. Pharmacists have both the right and obligation to refuse to fill
prescriptions that may harm patients.
Question 9
Under the HIPAA Privacy Rule, a pharmacy may disclose protected health information (PHI)
without patient authorization for:
A. Marketing purposes
B. Sale of PHI to data brokers
C. Treatment, payment, and healthcare operations (TPO)
D. Research without IRB approval
Correct Answer: C
Rationale: The HIPAA Privacy Rule permits disclosure of PHI without patient authorization for
treatment, payment, and healthcare operations (TPO). Marketing, sale of PHI, and most
research require patient authorization. The minimum necessary standard applies to all
disclosures except treatment and patient-requested disclosures.
Question 10
What is the maximum number of pharmacy technicians a pharmacist may supervise at one time
