APEA WOMEN'S HEALTH FINAL EXAM
& PRACTICE EXAM 2 2026 question and
answers
Question 1
A 49-year-old woman with HER2-positive breast cancer is preparing to begin trastuzumab
therapy. Which baseline assessment is the highest priority before the first dose?
A) Pulmonary function test
B) Echocardiogram to assess left ventricular ejection fraction (LVEF)
C) Colonoscopy
D) Bone density scan
Correct Answer: B
Rationale: Trastuzumab can cause cardiomyopathy. Baseline and periodic evaluation of LVEF
is recommended before and during treatment.
Question 2
A patient receiving trastuzumab develops dyspnea, fatigue, and bilateral ankle edema. Which
adverse effect should the provider suspect first?
A) Acute renal failure
B) Congestive heart failure
C) Hyperthyroidism
D) Pulmonary fibrosis
Correct Answer: B
Rationale: These symptoms are consistent with trastuzumab-induced cardiac dysfunction.
Question 3
,APEA WOMEN'S HEALTH FINAL EXAM
& PRACTICE EXAM 2 2026 question and
answers
A 46-year-old woman taking tamoxifen reports new-onset vaginal bleeding. What is the nurse
practitioner's priority action?
A) Reassure the patient that this is expected
B) Recommend increasing fluid intake
C) Arrange prompt evaluation for possible endometrial pathology
D) Discontinue calcium supplements
Correct Answer: C
Rationale: Tamoxifen increases the risk of endometrial hyperplasia and endometrial cancer.
Abnormal uterine bleeding requires evaluation.
Question 4
Tamoxifen produces its therapeutic effect in breast cancer by:
A) Increasing estrogen production
B) Blocking estrogen receptors in breast tissue
C) Destroying ovarian follicles
D) Stimulating progesterone secretion
Correct Answer: B
Question 5
Which medication class is commonly recommended as first-line endocrine therapy for many
postmenopausal women with hormone receptor-positive breast cancer?
A) Aromatase inhibitors
,APEA WOMEN'S HEALTH FINAL EXAM
& PRACTICE EXAM 2 2026 question and
answers
B) Beta-blockers
C) Corticosteroids
D) Calcium-channel blockers
Correct Answer: A
Question 6
A woman taking tamoxifen develops sudden unilateral calf pain and swelling. Which
complication is most concerning?
A) Osteoarthritis
B) Deep vein thrombosis
C) Peripheral neuropathy
D) Cellulitis
Correct Answer: B
Question 7
Which adverse effect should be discussed with women beginning aromatase inhibitor therapy?
A) Increased bone loss and fracture risk
B) Cataracts
C) Renal failure
D) Hyperkalemia
Correct Answer: A
, APEA WOMEN'S HEALTH FINAL EXAM
& PRACTICE EXAM 2 2026 question and
answers
Question 8
Which finding would most likely require interruption of trastuzumab therapy?
A) Mild nausea
B) Decreased left ventricular ejection fraction
C) Temporary hair thinning
D) Mild constipation
Correct Answer: B
Question 9
Before initiating tamoxifen therapy, clinicians should educate patients to promptly report:
A) Mild hot flashes
B) Abnormal vaginal bleeding
C) Dry skin
D) Occasional headache
Correct Answer: B
Question 10
A patient asks why cardiac function is monitored throughout trastuzumab treatment. The best
response is:
A) The medication may reduce heart pumping function over time.
& PRACTICE EXAM 2 2026 question and
answers
Question 1
A 49-year-old woman with HER2-positive breast cancer is preparing to begin trastuzumab
therapy. Which baseline assessment is the highest priority before the first dose?
A) Pulmonary function test
B) Echocardiogram to assess left ventricular ejection fraction (LVEF)
C) Colonoscopy
D) Bone density scan
Correct Answer: B
Rationale: Trastuzumab can cause cardiomyopathy. Baseline and periodic evaluation of LVEF
is recommended before and during treatment.
Question 2
A patient receiving trastuzumab develops dyspnea, fatigue, and bilateral ankle edema. Which
adverse effect should the provider suspect first?
A) Acute renal failure
B) Congestive heart failure
C) Hyperthyroidism
D) Pulmonary fibrosis
Correct Answer: B
Rationale: These symptoms are consistent with trastuzumab-induced cardiac dysfunction.
Question 3
,APEA WOMEN'S HEALTH FINAL EXAM
& PRACTICE EXAM 2 2026 question and
answers
A 46-year-old woman taking tamoxifen reports new-onset vaginal bleeding. What is the nurse
practitioner's priority action?
A) Reassure the patient that this is expected
B) Recommend increasing fluid intake
C) Arrange prompt evaluation for possible endometrial pathology
D) Discontinue calcium supplements
Correct Answer: C
Rationale: Tamoxifen increases the risk of endometrial hyperplasia and endometrial cancer.
Abnormal uterine bleeding requires evaluation.
Question 4
Tamoxifen produces its therapeutic effect in breast cancer by:
A) Increasing estrogen production
B) Blocking estrogen receptors in breast tissue
C) Destroying ovarian follicles
D) Stimulating progesterone secretion
Correct Answer: B
Question 5
Which medication class is commonly recommended as first-line endocrine therapy for many
postmenopausal women with hormone receptor-positive breast cancer?
A) Aromatase inhibitors
,APEA WOMEN'S HEALTH FINAL EXAM
& PRACTICE EXAM 2 2026 question and
answers
B) Beta-blockers
C) Corticosteroids
D) Calcium-channel blockers
Correct Answer: A
Question 6
A woman taking tamoxifen develops sudden unilateral calf pain and swelling. Which
complication is most concerning?
A) Osteoarthritis
B) Deep vein thrombosis
C) Peripheral neuropathy
D) Cellulitis
Correct Answer: B
Question 7
Which adverse effect should be discussed with women beginning aromatase inhibitor therapy?
A) Increased bone loss and fracture risk
B) Cataracts
C) Renal failure
D) Hyperkalemia
Correct Answer: A
, APEA WOMEN'S HEALTH FINAL EXAM
& PRACTICE EXAM 2 2026 question and
answers
Question 8
Which finding would most likely require interruption of trastuzumab therapy?
A) Mild nausea
B) Decreased left ventricular ejection fraction
C) Temporary hair thinning
D) Mild constipation
Correct Answer: B
Question 9
Before initiating tamoxifen therapy, clinicians should educate patients to promptly report:
A) Mild hot flashes
B) Abnormal vaginal bleeding
C) Dry skin
D) Occasional headache
Correct Answer: B
Question 10
A patient asks why cardiac function is monitored throughout trastuzumab treatment. The best
response is:
A) The medication may reduce heart pumping function over time.
