,LEHNE’S
PHARMACOTHERAPEUTICS
for Advanced Practice Nurses
and Physician Assistants
THIRD EDITION
LAURA D. ROSENTHAL, DNP, RN, ACNP-BC, FAANP
Professor, College of Nursing
University of Colorado Anschutz Medical Campus
Aurora, Colorado
JACQUELINE ROSENJACK BURCHUM, DNSc, FNP-BC, CNE
Associate Professor, College of Nursing
Department of Advanced Practice and Doctoral Studies
University of Tennessee Health Science Center
Memphis, Tennessee
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2019v1.0
, CONTENTS
UNIT I Introduction 31 Central Nervous System Stimulants and Attention-Deficit/
Hyperactivity Disorder, 246
1 Prescriptive Authority, 1
2 Rational Drug Selection and Prescription Writing, 6 UNIT VIII Substance Use Disorders
3 Promoting Positive Outcomes of Drug Therapy, 10
32 Substance Use Disorders I: Basic Considerations, 253
UNIT II Basic Principles of Pharmacology 33 Substance Use Disorders II: Alcohol, 258
34 Substance Use Disorders III: Nicotine and Smoking, 265
4 Pharmacokinetics, Pharmacodynamics, and Drug 35 Substance Use Disorders IV: Major Drugs of Misuse Other
Interactions, 15 Than Alcohol and Nicotine, 270
5 Adverse Drug Reactions and Medication Errors, 36
6 Individual Variation in Drug Responses, 44 UNIT IX Drugs That Affect the Heart, Blood
7 Genetic and Genomic Considerations in
Pharmacotherapeutics, 48 Vessels, Blood, and Blood Volume
36 Review of Hemodynamics, 281
UNIT III Drug Therapy Across the Life Span 37 Diuretics, 286
38 Drugs Acting on the Renin-Angiotensin-Aldosterone
8 Drug Therapy During Pregnancy and Breastfeeding, 53 System, 293
9 Drug Therapy in Pediatric Patients, 59 39 Calcium Channel Blockers, 304
10 Drug Therapy in Geriatric Patients, 63 40 Vasodilators, 309
41 Drugs for Hypertension, 312
UNIT IV Peripheral Nervous System Drugs 42 Drugs for Heart Failure, 321
43 Antidysrhythmic Drugs, 333
11 Basic Principles of Neuropharmacology, 69 44 Prophylaxis of Atherosclerotic Cardiovascular Disease:
12 Physiology of the Peripheral Nervous System, 73 Drugs That Help Normalize Cholesterol and Triglyceride
13 Muscarinic Agonists and Cholinesterase Inhibitors, 83 Levels, 345
14 Muscarinic Antagonists, 92 45 Drugs for Angina Pectoris, 360
15 Adrenergic Agonists, 100 46 Anticoagulant and Antiplatelet Drugs, 368
16 Adrenergic Antagonists, 109 47 Drugs for Deficiency Anemias, 385
17 Indirect-Acting Antiadrenergic Agents, 120
UNIT X Drugs for Endocrine Disorders
UNIT V Central Nervous System Drugs
48 Drugs for Diabetes, 393
18 Introduction to Central Nervous System 49 Drugs for Thyroid Disorders, 416
Pharmacology, 125
19 Drugs for Parkinson Disease, 127 UNIT XI Reproductive Health
20 Drugs for Alzheimer Disease, 144
21 Drugs for Seizure Disorders, 152 50 Estrogens and Progestins: Basic Pharmacology and
22 Drugs for Muscle Spasm and Spasticity, 169 Noncontraceptive Applications, 425
51 Birth Control, 437
UNIT VI Drugs for Pain 52 Androgens, 447
53 Drugs for Benign Prostatic Hyperplasia, 453
23 Local Anesthetics, 177 54 Drugs for Sexual Dysfunction, 457
24 Opioid Analgesics, Opioid Antagonists, and Nonopioid 55 Transgender Health, 466
Centrally Acting Analgesics, 181
25 Drugs for Headache, 192 UNIT XII Antiinflammatory, Antiallergic,
and Immunologic Drugs
UNIT VII Psychotherapeutic Drugs
56 Review of the Immune System, 475
26 Antipsychotic Agents and Their Use in Schizophrenia, 201 57 Childhood Immunization, 484
27 Antidepressants, 212 58 Antihistamines, 495
28 Drugs for Bipolar Disorder, 226 59 Cyclooxygenase Inhibitors, Nonsteroidal
29 Sedative-Hypnotic Drugs, 232 Antiinflammatory Drugs, and Acetaminophen, 500
30 Management of Anxiety Disorders, 241 60 Glucocorticoids in Nonendocrine Disorders, 510
PHARMACOTHERAPEUTICS
for Advanced Practice Nurses
and Physician Assistants
THIRD EDITION
LAURA D. ROSENTHAL, DNP, RN, ACNP-BC, FAANP
Professor, College of Nursing
University of Colorado Anschutz Medical Campus
Aurora, Colorado
JACQUELINE ROSENJACK BURCHUM, DNSc, FNP-BC, CNE
Associate Professor, College of Nursing
Department of Advanced Practice and Doctoral Studies
University of Tennessee Health Science Center
Memphis, Tennessee
,YOU’VE JUST PURCHASED
MORE THAN
A TEXTBOOK!
Enhance your learning with Evolve Student Resources.
These online study tools and exercises can help deepen your
understanding of textbook content so you can be more
prepared for class, perform better on exams, and succeed
in your course.
Activate the complete learning experience that comes with each
NEW textbook purchase by registering with your scratch-off access code at
http://evolve.elsevier.com/Rosenthal/pharmacotherapeutics/
If your school uses its own Learning Management System, your resources may be
delivered on that platform. Consult with your instructor.
If you rented or purchased a used book and the scratch-off code at right
has already been revealed, the code may have been used and cannot
be re-used for registration. To purchase a new code to access these
Place
valuable study resources, simply follow the link above.
Sticker
Here
REGISTER TODAY!
You can now purchase Elsevier products on Evolve!
Go to evolve.elsevier.com/shop to search and browse for products.
2019v1.0
, CONTENTS
UNIT I Introduction 31 Central Nervous System Stimulants and Attention-Deficit/
Hyperactivity Disorder, 246
1 Prescriptive Authority, 1
2 Rational Drug Selection and Prescription Writing, 6 UNIT VIII Substance Use Disorders
3 Promoting Positive Outcomes of Drug Therapy, 10
32 Substance Use Disorders I: Basic Considerations, 253
UNIT II Basic Principles of Pharmacology 33 Substance Use Disorders II: Alcohol, 258
34 Substance Use Disorders III: Nicotine and Smoking, 265
4 Pharmacokinetics, Pharmacodynamics, and Drug 35 Substance Use Disorders IV: Major Drugs of Misuse Other
Interactions, 15 Than Alcohol and Nicotine, 270
5 Adverse Drug Reactions and Medication Errors, 36
6 Individual Variation in Drug Responses, 44 UNIT IX Drugs That Affect the Heart, Blood
7 Genetic and Genomic Considerations in
Pharmacotherapeutics, 48 Vessels, Blood, and Blood Volume
36 Review of Hemodynamics, 281
UNIT III Drug Therapy Across the Life Span 37 Diuretics, 286
38 Drugs Acting on the Renin-Angiotensin-Aldosterone
8 Drug Therapy During Pregnancy and Breastfeeding, 53 System, 293
9 Drug Therapy in Pediatric Patients, 59 39 Calcium Channel Blockers, 304
10 Drug Therapy in Geriatric Patients, 63 40 Vasodilators, 309
41 Drugs for Hypertension, 312
UNIT IV Peripheral Nervous System Drugs 42 Drugs for Heart Failure, 321
43 Antidysrhythmic Drugs, 333
11 Basic Principles of Neuropharmacology, 69 44 Prophylaxis of Atherosclerotic Cardiovascular Disease:
12 Physiology of the Peripheral Nervous System, 73 Drugs That Help Normalize Cholesterol and Triglyceride
13 Muscarinic Agonists and Cholinesterase Inhibitors, 83 Levels, 345
14 Muscarinic Antagonists, 92 45 Drugs for Angina Pectoris, 360
15 Adrenergic Agonists, 100 46 Anticoagulant and Antiplatelet Drugs, 368
16 Adrenergic Antagonists, 109 47 Drugs for Deficiency Anemias, 385
17 Indirect-Acting Antiadrenergic Agents, 120
UNIT X Drugs for Endocrine Disorders
UNIT V Central Nervous System Drugs
48 Drugs for Diabetes, 393
18 Introduction to Central Nervous System 49 Drugs for Thyroid Disorders, 416
Pharmacology, 125
19 Drugs for Parkinson Disease, 127 UNIT XI Reproductive Health
20 Drugs for Alzheimer Disease, 144
21 Drugs for Seizure Disorders, 152 50 Estrogens and Progestins: Basic Pharmacology and
22 Drugs for Muscle Spasm and Spasticity, 169 Noncontraceptive Applications, 425
51 Birth Control, 437
UNIT VI Drugs for Pain 52 Androgens, 447
53 Drugs for Benign Prostatic Hyperplasia, 453
23 Local Anesthetics, 177 54 Drugs for Sexual Dysfunction, 457
24 Opioid Analgesics, Opioid Antagonists, and Nonopioid 55 Transgender Health, 466
Centrally Acting Analgesics, 181
25 Drugs for Headache, 192 UNIT XII Antiinflammatory, Antiallergic,
and Immunologic Drugs
UNIT VII Psychotherapeutic Drugs
56 Review of the Immune System, 475
26 Antipsychotic Agents and Their Use in Schizophrenia, 201 57 Childhood Immunization, 484
27 Antidepressants, 212 58 Antihistamines, 495
28 Drugs for Bipolar Disorder, 226 59 Cyclooxygenase Inhibitors, Nonsteroidal
29 Sedative-Hypnotic Drugs, 232 Antiinflammatory Drugs, and Acetaminophen, 500
30 Management of Anxiety Disorders, 241 60 Glucocorticoids in Nonendocrine Disorders, 510
