NRNP 6566 / NRNP6566 Advanced
Care of Adults in Acute Settings I
Week 5 Knowledge Check |
Questions and Verified Answers |
Latest
Answer: Cytochrome p450 system is a series of
enzymes used to metabolize medications
Q: Describe cytochrome p450 system
Answer: block metabolic activity from one or more
CYP450 enzymes
Q: Inhibitors
Answer: increase CYP450 enzyme activity by
increasing enzyme synthesis
Q: Inducers
Answer: Albumin is the plasma protein with the
greatest capacity for binding drugs. Binding plasma
proteins affect drug distribution into tissues because
only drug that is not bound is available to penetrate
tissues bind to receptors and exert activity. As free
drug leaves the blood stream more bound drug is
released from binding sites.
Q: Describe effect on low and high albumin levels
on active drug levels especially for drugs that are
highly protein bound
Answer: malnutrition chronic illness
Q: Low albumin levels
, Answer: toxicity in patients with low albumin
levels example malnutrition or chronic illness. This
is because there are fewer than the normal sites for
the drug to bind
Q: Highly protein bound drugs can lead to
Answer: Alternative routes include suppository
intravenous intramuscular inhalational aerosol
transdermal sublingual These allow drugs to bypass the
first-pass effect and be absorbed directly into
systemic circulation
Q: Describe the ways the hepatic first pass
effect- which is metabolism during first pass through
the liver
Answer: Male = 140-age times weight in kilograms
divided by serum creatinine times 72. Women = CRCL
(male) times 0.85
Q: Be able to calculate creatinine clearance using
Coc graft Gault equation:
Answer: half-life plasma concentration
Q: Describe what defines the frequency of drug
administration
Answer: Potentially Inappropriate Medication Use
in Older Adults to call attention to medications that
are most commonly problematic and thus should be
avoided in older adults
Q: Be familiar with the beers criteria and how to
use it
Answer: low blood state (shock or arrest) contact
time with GI tract too fast (diarrhea = can’t absorb)
delayed stomach emptying (large meal = delayed
absorption) Drug- to drug or drug to food interactions
Q: Describe factors that affect absorption
Care of Adults in Acute Settings I
Week 5 Knowledge Check |
Questions and Verified Answers |
Latest
Answer: Cytochrome p450 system is a series of
enzymes used to metabolize medications
Q: Describe cytochrome p450 system
Answer: block metabolic activity from one or more
CYP450 enzymes
Q: Inhibitors
Answer: increase CYP450 enzyme activity by
increasing enzyme synthesis
Q: Inducers
Answer: Albumin is the plasma protein with the
greatest capacity for binding drugs. Binding plasma
proteins affect drug distribution into tissues because
only drug that is not bound is available to penetrate
tissues bind to receptors and exert activity. As free
drug leaves the blood stream more bound drug is
released from binding sites.
Q: Describe effect on low and high albumin levels
on active drug levels especially for drugs that are
highly protein bound
Answer: malnutrition chronic illness
Q: Low albumin levels
, Answer: toxicity in patients with low albumin
levels example malnutrition or chronic illness. This
is because there are fewer than the normal sites for
the drug to bind
Q: Highly protein bound drugs can lead to
Answer: Alternative routes include suppository
intravenous intramuscular inhalational aerosol
transdermal sublingual These allow drugs to bypass the
first-pass effect and be absorbed directly into
systemic circulation
Q: Describe the ways the hepatic first pass
effect- which is metabolism during first pass through
the liver
Answer: Male = 140-age times weight in kilograms
divided by serum creatinine times 72. Women = CRCL
(male) times 0.85
Q: Be able to calculate creatinine clearance using
Coc graft Gault equation:
Answer: half-life plasma concentration
Q: Describe what defines the frequency of drug
administration
Answer: Potentially Inappropriate Medication Use
in Older Adults to call attention to medications that
are most commonly problematic and thus should be
avoided in older adults
Q: Be familiar with the beers criteria and how to
use it
Answer: low blood state (shock or arrest) contact
time with GI tract too fast (diarrhea = can’t absorb)
delayed stomach emptying (large meal = delayed
absorption) Drug- to drug or drug to food interactions
Q: Describe factors that affect absorption
