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CCTC Transplant -Pharmacology Exam Questions and Answers.

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CCTC Transplant -Pharmacology Exam Questions and Answers.

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CCTC Transplant -Pharmacology Exam
Questions and Answers
Question 1
Antiproliferative Azathioprine (Imuran) MOA
Correct Answer
interrupts DNA structure in lymphocytes preventing transcription. (cytotoxic).



Question 2
Meds that raise tacrolimus & cyclosporine & Sirolimus trough levels
Correct Answer
Macrolide ABX(erythromycin & clarithromycin).
Diltiazem
verapamil
high dose steroids
azole antifungals
grapefruit (squirt & fresca)
sirolimus



Question 3
tacrolimus dosage
Correct Answer
0.2 mg/kg/day divided into 2 doses.
IV form highly Nephrotoxic.



Question 4
blood levels of MPA
Correct Answer
not usually done except for in heart transplants.

goal 3-8




Page 1 of 10

, Question 5
is sirolimus Nephrotoxic?
Correct Answer
no



Question 6
azathioprine (Imuran) adverse effects
Correct Answer
leukopenia
thrombocytopenia
anemia
N/V
hepatotoxicity
pancreatitis
skin cancers/skin lesions



Question 7
mycophenolic acid (MPA) adverse effects
Correct Answer
1. GI upset- (diarrhea, nausea, abdominal discomfort, may lead to ulcer).
2. Hematologic-leukopenia, thrombocytopenia, anemia.
3. Increased risk of viral infections.
4. myfortic- lower GI upset d/t enteric coating.



Question 8
Sirolimus in combination with a CNI (Calcineurin inhibitor) drug range usually runs
higher or lower?

Correct Answer
lower
sirolimus with CNI 5-10.
without CNI 15-20.




Page 2 of 10

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