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HESI RN Advanced Pathophysiology Exam

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This document is a study guide or practice exam for the HESI RN Advanced Pathophysiology exam. It features over 160 questions and answers with rationales covering fundamental pathophysiological concepts. Topics include cellular adaptation, mechanisms of disease, the stress response, genetics, immunology, oncology, and detailed pathophysiology of various body systems such as cardiovascular, pulmonary, renal, and endocrine. It is designed to test knowledge on the underlying mechanisms of disease processes and their clinical manifestations.

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HESI RN ADVANCED PATHOPHYSIOLOGY
2025-2026 ACTUAL EXAM 160 QUESTIONS
AND CORRECT DETAILED ANSWERS WITH
RATIONALES (VERIFIED ANSWERS) |ALREADY
D
O
N
O
T
C
O

Which term is used for the first two months of life?
PY

a. Infancy
b. Childhood
c. Prenatal
d. Neonatal - ANSWER-d. Neonatal

,An initial disturbance in a system sets off a chain of events that
does not favor stability and often abruptly displaces a system
from its steady state: what is that? a. Positive Feedback
b. Negative Feedback
c. Disease
d. Homeostasis - ANSWER-a. positive feedback
D

What organ shrinks with age? a.
O

Prostate
N

b. Gums
O

c. Heart
T

d. All of the above - ANSWER-b. gums
C
O

Which of the following is true?
PY

a. An infant will have a slower heart rate than an adult
b. The elderly have better temperature sensations
c. There are more sweat glands in an elderly person
d. There is less thirst perception in the elderly - ANSWER-d.
there is less thirst perception in the elderly


Which of the following is true?

,a. Women snore more than men
b. Men have higher calcium levels
c. Women have a lower hemoglobin than men
d. Men have a lower creatinine level than women - ANSWER-c.
Women have a lower hemoglobin than men


An increase in normal adaptive response to the decreased
D

availability of oxygen at high altitude is termed which? a.
O

Circadian
N

b. Acclimatization
O

c. Population
T

d. Diurnal - ANSWER-b. Acclimatization
C

What does it mean when the cause of the disease is unwanted
O

medical treatment? a. Idiopathic
PY

b. Ecogenetic
c. Genotypical
d. Iatrogenic - ANSWER-d. Iatrogenic


Which is an objectively identifiable aberration of the disease? a.
Symptom

, b. Syndrome
c. Stage
d. Sign - ANSWER-d. Sign


Which of the following is true regarding catecholamines? a.
They are from the parasympathetic nervous system
D

b. They cross the blood brain barrier
O

c. They include epinephrine and norepinephrine
d. They cause of decrease in heart rate - ANSWER-c. They
N

include epinephrine and norepinephrine
O
T

Which of the following is a true statement?
C

a. Antidiuretic hormone is not important for blood volume
O

regulation
PY

b. Endorphins increase with stress, resulting in a decrease in
pain perception
c. Epinephrine and cortisol act very differently
d. Cortisol negates epinephrine's activity - ANSWER-b.
Endorphins increase with stress, resulting in a decrease in
pain perception

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