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AGACNP 106 Comprehensive Exam 2026 Study Guide

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This comprehensive exam preparation document contains over 100 questions and answers for the Adult-Gerontology Acute Care Nurse Practitioner (AGACNP) certification exam. The material covers a wide range of clinical topics essential for advanced practice nursing, including differential diagnosis, pharmacology, laboratory interpretation, evidence-based practice, and clinical management across multiple body systems. Key topics include endocrine disorders (Addison's disease, Cushing's disease, hypothyroidism, pheochromocytoma), cardiovascular conditions (pericarditis, cardiac tamponade, aortic stenosis, mitral stenosis), pulmonary disorders (ARDS, COPD, VAP), gastrointestinal conditions (diverticulitis, ulcerative colitis, pancreatitis), renal disorders (acute kidney injury, nephrolithiasis), and oncology. The guide also covers important practice management topics including credentialing, licensure, Medicare coverage, research methodology, statistics (Type I/II errors, p-values, sensitivity/specificity), preventive health screening guidelines, and ethical principles in healthcare.

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AGACNP 106 DOCUMENT COMPREHENSIVE
EXAM 2026 QUESTIONS WITH ANSWERS
GRADED A+



What disease conditions do you see Telangiectasia in?
Differential?
- ✔✔✔ANSW
Physical Exam? ✔✔..-("spider veins") dilated or broken
D

blood vessels located near the surface of the skin or mucous membranes.
O

-Rosasea
-Liver dx
N

-Scleroderma
O

-Lupus
-Corticosteriod use
T

-Raynauds
-Basal cell Skin CA
C
O

-Differential: PVD
-PE: Hemosiderans deposition (staining)
PY

Type 1 Error - ✔✔✔ANSW✔✔..-False positive
-Incorrectly rejecting the true null hypothesis (occurs if the null
hypothesis is rejected when it is true)
-Rejection of the null hypothesis when it is actually true.

Type 2 Error - ✔✔✔ANSW✔✔..-False negative
-Failing to reject a null hypothesis which is false (occurs if the null
hypothesis is not rejected when it is false)

,National mandate to prevent VAP? - ✔✔✔ANSW✔✔..Elevate the HOB
Credentials - ✔✔✔ANSW✔✔..1. Encompass required education,
licensure and certification
2. Establish minimal levels of acceptable performance
3. Necessary to: ensure the safe healthcare is provided by qualified
individuals and comply with federal and state laws relating to
advanced practice nursing
4. Scope of practice
5. Mandates accountability
6. Enforces professional standards of practice
D

What is credentialing or priviliging? - ✔✔✔ANSW✔✔..-Process by
O

which a NP is granted permission to practice in an inpatient setting
-Credentialing with hospital privileges is granted by a Hospital
N

Credentialing Committee comprised of MDs who hold privileges at the
O

given hospital where the NP has made request
-Privileges may be granted in part or full; stipulations regarding the
T

allowance of future privileges may be made by the Credentialing
Committee
C
O

Licensure - ✔✔✔ANSW✔✔..-Establishes that a person is qualified to
perform in a particular profession.
PY

-Granted as defined by rules and regulations set forth by a governmental
regulatory body

Who gives licensure? - ✔✔✔ANSW✔✔..State board of nursing

What is sensitivity? - ✔✔✔ANSW✔✔..-True positives
-The degree to which those who have a disease screen/test positive

What is specificity? - ✔✔✔ANSW✔✔..-True negatives

, -The degree to which those who do not have a disease screen/test
negative

What is null hypothesis?
What if the null hypothesis is rejected? - ✔✔✔ANSW✔✔..-There is no
significant relation between the variables of the study
-Results are due to chance and are not significant in terms of supporting
the idea being investigated. Thus, the null hypothesis assumes that
whatever you are trying to prove did not happen
-It means the results of the study are not due to chance
D

What is p-value? - ✔✔✔ANSW✔✔..-Number describing how likely it
O

is that your data would have occurred by random chance (i.e. that the
null hypothesis is true).
N

-0.05 as the standard level of significance
O

-The smaller the p-value, the stronger the evidence that you should reject
the null hypothesis
T

if P<0.05 it? - ✔✔✔ANSW✔✔..-Rejects null hypothesis
C

-Statistically significant
O

-A significant result and this would have only arose 5/100 times through
chance
PY

-Experimental and control groups are considered to be significantly
different

if p>0.05? - ✔✔✔ANSW✔✔..-Fail to reject the null hypothesis
-Not statistically significant and indicates strong evidence for the null
hypothesis

What is treatment for VAP? - ✔✔✔ANSW✔✔..Cover MRSA+ Double
antipseudomonal coverage
-Abs with MRSA activity = vanc or linezolid

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