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Medical-Surgical Nursing (Med Surg) HESI Exam V1 & V2 (2026/2027)
Comprehensive Practice Exam with Verified Rationales
Table of Contents
Section Topic
1 Cardiovascular Disorders
2 Respiratory Disorders
3 Neurological Disorders
4 Gastrointestinal Disorders
5 Endocrine Disorders
6 Renal & Urinary Disorders
7 Musculoskeletal Disorders
8 Hematologic & Immune Disorders
9 Oncology Nursing
10 Perioperative Nursing
11 Infection Control & Safety
12 Pharmacology
13 Comprehensive Practice Questions
14 Answer Key with Rationales
,Introduction
This comprehensive Medical-Surgical Nursing (Med Surg) HESI practice exam is
designed to help nursing students review major concepts commonly tested in
medical-surgical nursing. The questions emphasize clinical judgment, nursing
priorities, patient safety, pharmacology, and evidence-based nursing care.
Section 1: Cardiovascular Disorders
Question 1
A client with heart failure reports increasing shortness of breath and has bilateral crackles.
Which intervention should the nurse perform first?
A. Administer prescribed IV furosemide.
B. Elevate the head of the bed.
C. Restrict oral fluids.
D. Obtain daily weight.
Answer: B
Rationale:
Positioning the patient upright immediately improves ventilation and reduces preload while
additional interventions are prepared.
Question 2
Which laboratory value is most important to monitor before administering digoxin?
A. Hemoglobin
B. Potassium
C. Sodium
D. Platelets
Answer: B
Rationale:
Hypokalemia significantly increases the risk of digoxin toxicity.
, Question 3
A patient receiving heparin develops bleeding gums. Which laboratory test should the nurse
review first?
A. INR
B. aPTT
C. BNP
D. Troponin
Answer: B
Section 2: Respiratory Disorders
Question 4
Which finding requires immediate intervention in a patient with COPD receiving oxygen
therapy?
A. Oxygen saturation 92%
B. Respiratory rate 22/min
C. Increasing drowsiness
D. Productive cough
Answer: C
Rationale:
Increasing drowsiness may indicate carbon dioxide retention and impending respiratory failure.
Question 5
Which patient should the nurse assess first?
A. Asthma patient with expiratory wheezes
B. Pneumonia patient with temperature of 101°F
C. Pulmonary embolism patient reporting sudden chest pain
D. COPD patient requesting pain medication
Answer: C