EDAPT ANTI INFLAMMATORY QUESTIONS AND
ANSWERS SURE A+
✔✔Too much uric acid in the blood is known as __________. - ✔✔Hyperuricemia
✔✔Uric acid is produced as part of the metabolism process of __________. -
✔✔Purines
✔✔Which drug class is first used when treating clients with gout? - ✔✔Nonsteroidal
anti-inflammatory drugs (NSAIDs)
✔✔Nonsteroidal anti-inflammatory drugs (NSAIDs) taken for the treatment of gout can
impact the __________ without altering __________. - ✔✔Client's pain level
How the body metabolizes purines
✔✔The nurse verifying new medications prescribed for an adult client with gout should
contact the healthcare provider (HCP) for which ordered daily dose? - ✔✔1 gram
✔✔Why is allopurinol considered safer than febuxostat? - ✔✔Allopurinol has a lower
risk for serious cardiovascular effects.
, ✔✔Colchicine is thought to __________ the metabolism, mobility, and chemotaxis of
polymorphonuclear leukocytes. - ✔✔Inhibit
✔✔The nurse is preparing to administer probenecid to several clients with gout. For
which clients should the nurse contact the healthcare provider prior to giving the
medicine? Select all that apply. - ✔✔A client admitted with renal calculi.
The client experiencing an acute gouty attack.
An older adult who takes a baby aspirin daily.
✔✔What is involved in the pathophysiology of gout? - ✔✔Inflammation resulting from
intraarticular deposition of urate crystals.
✔✔What client information indicates that probenecid remains effective in a client who
has been taking the medication for 6 months? Select all that apply. - ✔✔Decreased pain
No acute gouty attacks in 5 months
Decreased serum uric acid levels
✔✔Drag and drop to match the drug to the mechanism of action. - ✔✔*Probenecid* -
Inhibits the reabsorption of uric acid in the kidney and thus increases the excretion of
uric acid.
*Febuxostat* - Selectively inhibits the xanthine oxidase enzyme to reduce uric acid
production.
*Allopurinol* - Inhibits the enzyme xanthine oxidase which prevents uric acid production.
*Colchicine* - Not clearly defined, but it is thought to inhibit the metabolism, mobility,
and chemotaxis of polymorphonuclear leukocytes.
✔✔Drag and drop to match the drug to its indication. - ✔✔*Colchicine* - Treatment and
prophylaxis of acute attacks.
*Allopurinol* - Overproduction of uric acid (hyperuricemia).
*Probenecid* - Underexcretion of uric acid by the kidneys.
✔✔Match the contraindication for use to the correct medication. - ✔✔*Allopurinol* -
Presence of HLA-B*58:01 allele
*Colchicine* - Renal impairment
*Febuxostat* - Concurrent use with azathioprine
*Probenecid* = Concurrent use with aspirin therapy
ANSWERS SURE A+
✔✔Too much uric acid in the blood is known as __________. - ✔✔Hyperuricemia
✔✔Uric acid is produced as part of the metabolism process of __________. -
✔✔Purines
✔✔Which drug class is first used when treating clients with gout? - ✔✔Nonsteroidal
anti-inflammatory drugs (NSAIDs)
✔✔Nonsteroidal anti-inflammatory drugs (NSAIDs) taken for the treatment of gout can
impact the __________ without altering __________. - ✔✔Client's pain level
How the body metabolizes purines
✔✔The nurse verifying new medications prescribed for an adult client with gout should
contact the healthcare provider (HCP) for which ordered daily dose? - ✔✔1 gram
✔✔Why is allopurinol considered safer than febuxostat? - ✔✔Allopurinol has a lower
risk for serious cardiovascular effects.
, ✔✔Colchicine is thought to __________ the metabolism, mobility, and chemotaxis of
polymorphonuclear leukocytes. - ✔✔Inhibit
✔✔The nurse is preparing to administer probenecid to several clients with gout. For
which clients should the nurse contact the healthcare provider prior to giving the
medicine? Select all that apply. - ✔✔A client admitted with renal calculi.
The client experiencing an acute gouty attack.
An older adult who takes a baby aspirin daily.
✔✔What is involved in the pathophysiology of gout? - ✔✔Inflammation resulting from
intraarticular deposition of urate crystals.
✔✔What client information indicates that probenecid remains effective in a client who
has been taking the medication for 6 months? Select all that apply. - ✔✔Decreased pain
No acute gouty attacks in 5 months
Decreased serum uric acid levels
✔✔Drag and drop to match the drug to the mechanism of action. - ✔✔*Probenecid* -
Inhibits the reabsorption of uric acid in the kidney and thus increases the excretion of
uric acid.
*Febuxostat* - Selectively inhibits the xanthine oxidase enzyme to reduce uric acid
production.
*Allopurinol* - Inhibits the enzyme xanthine oxidase which prevents uric acid production.
*Colchicine* - Not clearly defined, but it is thought to inhibit the metabolism, mobility,
and chemotaxis of polymorphonuclear leukocytes.
✔✔Drag and drop to match the drug to its indication. - ✔✔*Colchicine* - Treatment and
prophylaxis of acute attacks.
*Allopurinol* - Overproduction of uric acid (hyperuricemia).
*Probenecid* - Underexcretion of uric acid by the kidneys.
✔✔Match the contraindication for use to the correct medication. - ✔✔*Allopurinol* -
Presence of HLA-B*58:01 allele
*Colchicine* - Renal impairment
*Febuxostat* - Concurrent use with azathioprine
*Probenecid* = Concurrent use with aspirin therapy
