NR547 Week 5
Study online at https://quizlet.com/_dig39y
1. Medications for depression SSRIs
SNRIs
SDRIs
TCAs
MAOIs
2. SSRIs -Action: inhibit 5-HT reuptake
-Examples: citalopram, escitalopram, fluoxetine,
paroxetine, sertraline
-Adverse effects:
• nausea
• agitation
• diarrhea
• headache
• weight gain
• sexual side effects
3. SNRIs -inhibit 5-HT reuptake
-inhibit NE reuptake (‘energy, focus)
-increase DA in prefrontal cortex (‘cognition)
-Examples: desvenlafaxine, duloxetine, levomil-
nacipran, venlafaxine
-Adverse effects:
• elevated blood pressure
• nausea
• sweating
• tremors
• anxiety
• insomnia
• constipation
• anorexia
• sexual dysfunction
, NR547 Week 5
Study online at https://quizlet.com/_dig39y
4. SDRIs -inhibit DA reuptake (‘alertness, motivation)
-inhibit NE reuptake (‘energy)
-Adverse effects:
• agitation
• headache
• dry mouth
• constipation
• weight loss
5. TCAs -Action: inhibits the reuptake of serotonin and nor-
epinephrine; blocks norepinephrine, histamine, and
acetylcholine receptors
-Examples: amitriptyline, clomipramine, de-
sipramine, doxepin
-Common Side Effects:
• dry mouth
• constipation
• blurred vision
• urinary retention
• sedation
• weight gain
• hypotension
• tachycardia
• sexual dysfunction
6. MAOIs -Action: increases norepinephrine and serotonin by
inhibiting the enzyme that inactivates it
-Examples: isocarboxazid, phenelzine, tranyl-
cypromine
-Common Side Effects:
• sedation
, NR547 Week 5
Study online at https://quizlet.com/_dig39y
• dizziness
• sexual dysfunction
• hypertensive crisis
7. Prescribing pearls: citalopram mild antihistamine effects
(Celexa)
8. Prescribing pearls: escitalopram no known drug interactions
(Lexapro)
9. Prescribing pearls: fluoxetine (Prozac) longest half-life
10. Prescribing pearls: paroxetine (Paxil) also treats social anxiety and insomnia
11. Prescribing pearls: fluvoxamine (Lu- treats anxious depression smokers require in-
vox) creased dose
12. Prescribing pearls: sertraline (Zoloft) also treats social anxiety and hypersomnolence
13. Prescribing pearls: bupropion (Well- NDRI may improve energy, alertness, and motiva-
butrin) tion; not first line treatment for anxiety; contraindi-
cated in clients with a history of seizures
14. Prescribing pearls: duloxetine (Cym- effective for atypical pain at higher doses; appropri-
balta) ate for clients who present with somatic symptoms
of depression; effective for atypical pain, such as
fibromyalgia and diabetic neuropathy
15. Prescribing pearls: venlafaxine (Effex- treats both depression and anxiety disorders, ensure
or) trial of higher dose before switching to a different
medication
16. Prescribing pearls: desvenlafaxine effective for perimenopausal vasomotor symptoms
(Pristiq)
Study online at https://quizlet.com/_dig39y
1. Medications for depression SSRIs
SNRIs
SDRIs
TCAs
MAOIs
2. SSRIs -Action: inhibit 5-HT reuptake
-Examples: citalopram, escitalopram, fluoxetine,
paroxetine, sertraline
-Adverse effects:
• nausea
• agitation
• diarrhea
• headache
• weight gain
• sexual side effects
3. SNRIs -inhibit 5-HT reuptake
-inhibit NE reuptake (‘energy, focus)
-increase DA in prefrontal cortex (‘cognition)
-Examples: desvenlafaxine, duloxetine, levomil-
nacipran, venlafaxine
-Adverse effects:
• elevated blood pressure
• nausea
• sweating
• tremors
• anxiety
• insomnia
• constipation
• anorexia
• sexual dysfunction
, NR547 Week 5
Study online at https://quizlet.com/_dig39y
4. SDRIs -inhibit DA reuptake (‘alertness, motivation)
-inhibit NE reuptake (‘energy)
-Adverse effects:
• agitation
• headache
• dry mouth
• constipation
• weight loss
5. TCAs -Action: inhibits the reuptake of serotonin and nor-
epinephrine; blocks norepinephrine, histamine, and
acetylcholine receptors
-Examples: amitriptyline, clomipramine, de-
sipramine, doxepin
-Common Side Effects:
• dry mouth
• constipation
• blurred vision
• urinary retention
• sedation
• weight gain
• hypotension
• tachycardia
• sexual dysfunction
6. MAOIs -Action: increases norepinephrine and serotonin by
inhibiting the enzyme that inactivates it
-Examples: isocarboxazid, phenelzine, tranyl-
cypromine
-Common Side Effects:
• sedation
, NR547 Week 5
Study online at https://quizlet.com/_dig39y
• dizziness
• sexual dysfunction
• hypertensive crisis
7. Prescribing pearls: citalopram mild antihistamine effects
(Celexa)
8. Prescribing pearls: escitalopram no known drug interactions
(Lexapro)
9. Prescribing pearls: fluoxetine (Prozac) longest half-life
10. Prescribing pearls: paroxetine (Paxil) also treats social anxiety and insomnia
11. Prescribing pearls: fluvoxamine (Lu- treats anxious depression smokers require in-
vox) creased dose
12. Prescribing pearls: sertraline (Zoloft) also treats social anxiety and hypersomnolence
13. Prescribing pearls: bupropion (Well- NDRI may improve energy, alertness, and motiva-
butrin) tion; not first line treatment for anxiety; contraindi-
cated in clients with a history of seizures
14. Prescribing pearls: duloxetine (Cym- effective for atypical pain at higher doses; appropri-
balta) ate for clients who present with somatic symptoms
of depression; effective for atypical pain, such as
fibromyalgia and diabetic neuropathy
15. Prescribing pearls: venlafaxine (Effex- treats both depression and anxiety disorders, ensure
or) trial of higher dose before switching to a different
medication
16. Prescribing pearls: desvenlafaxine effective for perimenopausal vasomotor symptoms
(Pristiq)
