Entacapone/Tolcapone MOA
Give this one a try later!
-Entacapone is COMT inhibitor that primarily serves to INCREASE the
bioavailability of levodopa by INHIBITING PERPHERAL METHYLATION
-Tolcapone is another COMT inhibitor that inhibits BOTH peripheral and
central methylation. It has hepatoxic though..unlike entacapone
Eosinophilic cytoplasmic inclusion in nerve cell
Give this one a try later!
Lewy body (Parkinson disease)
,Iron poisoning with multiple blood transfusions tx
Give this one a try later!
Deferoxamine
Chest pain on exertion
Give this one a try later!
Angina (stable: with moderate exertion; unstable: with minimal exertion or
at rest)
Unilateral facial drooping involving forehead
Give this one a try later!
LMN facial nerve (CN VII) palsy; UMN lesions spare the forehead
Confusion + Ataxia + Opthalmoplegia
Give this one a try later!
, -Wernicke Encephalopathy due to chronic thiamine deficiency
-The infusion of glucose WITHOUT thiamine in pts with chronic thiamine
deficiency prepipiates encephalopathy because thiamine is a cofactor of
the enzymes responsible for glucose metabolism
Severe jaundice in neonate
Give this one a try later!
Crigler-Najjar syndrome (congenital unconjugated hyperbilirubinemia)
Diverticulum in pharynx
Give this one a try later!
Zenker diverticulum (diagnosed by barium swallow)
Kaposi's Sarcoma
Give this one a try later!
-Usually involve skin and GI tract in HIV pts
-Biopsy shows SPINDLE cells, neovascularization, and extravasated red
blood cells
, Stippled vaginal epithelial cells
Give this one a try later!
"Clue cells" (Gardnerella vaginalis)
Giant B cells with bilobed nuclei with prominent inclusions ("owl's eye")
Give this one a try later!
Reed-Sternberg cells (Hodgkin lymphoma)
Fall on the outstretched hand
Give this one a try later!
Damages the hook of the hamate
-Can result in Ulnar never injury
Abdominal pain, ascites, and hepatomegaly
Give this one a try later!
Budd-Chiari syndrome (posthepatic venous thrombosis)
-Absence of JVD
Give this one a try later!
-Entacapone is COMT inhibitor that primarily serves to INCREASE the
bioavailability of levodopa by INHIBITING PERPHERAL METHYLATION
-Tolcapone is another COMT inhibitor that inhibits BOTH peripheral and
central methylation. It has hepatoxic though..unlike entacapone
Eosinophilic cytoplasmic inclusion in nerve cell
Give this one a try later!
Lewy body (Parkinson disease)
,Iron poisoning with multiple blood transfusions tx
Give this one a try later!
Deferoxamine
Chest pain on exertion
Give this one a try later!
Angina (stable: with moderate exertion; unstable: with minimal exertion or
at rest)
Unilateral facial drooping involving forehead
Give this one a try later!
LMN facial nerve (CN VII) palsy; UMN lesions spare the forehead
Confusion + Ataxia + Opthalmoplegia
Give this one a try later!
, -Wernicke Encephalopathy due to chronic thiamine deficiency
-The infusion of glucose WITHOUT thiamine in pts with chronic thiamine
deficiency prepipiates encephalopathy because thiamine is a cofactor of
the enzymes responsible for glucose metabolism
Severe jaundice in neonate
Give this one a try later!
Crigler-Najjar syndrome (congenital unconjugated hyperbilirubinemia)
Diverticulum in pharynx
Give this one a try later!
Zenker diverticulum (diagnosed by barium swallow)
Kaposi's Sarcoma
Give this one a try later!
-Usually involve skin and GI tract in HIV pts
-Biopsy shows SPINDLE cells, neovascularization, and extravasated red
blood cells
, Stippled vaginal epithelial cells
Give this one a try later!
"Clue cells" (Gardnerella vaginalis)
Giant B cells with bilobed nuclei with prominent inclusions ("owl's eye")
Give this one a try later!
Reed-Sternberg cells (Hodgkin lymphoma)
Fall on the outstretched hand
Give this one a try later!
Damages the hook of the hamate
-Can result in Ulnar never injury
Abdominal pain, ascites, and hepatomegaly
Give this one a try later!
Budd-Chiari syndrome (posthepatic venous thrombosis)
-Absence of JVD
