1|Page
NORTH AMERICAN PHARMACIST LICENSURE
EXAMINATION
(NAPLEX) PRACTICE QUESTIONS WITH
VERIFIED ANSWERS 2026
A young adult female patient was prescribed an appropriate dose of Tylenol #3
during an emergency department visit. Within 48 hours, the patient was brought
back to the emergency department by ambulance due to respiratory depression
and somnolence. Which of the following is the most likely cause of this response?
Answer
A
The patient is HLA-B*5701 positive.
B
The patient has 2C192 or 3 alleles.
C
The patient is a 2D6 ultra-rapid metabolizer.
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D
The patient has a deficiency of thiopurine methyltransferase (TPMT).
E
The patient has 2C92 or 3 alleles. - correct-answer - C
The patient is a 2D6 ultra-rapid metabolizer.
A pharmacist will counsel a female patient who is beginning lamotrigine therapy
for bipolar disorder. There are no interacting medications on the profile. Which of
the following counseling statements should the pharmacist share with the
patient? (Select ALL that apply.)
Answer
A
This medication can cause serious skin reactions, including a very severe rash.
B
It is important that this medication is titrated slowly; follow the instructions
carefully.
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C
One of the brand names for this medication is Trileptal.
D
Your starter kit packaging should be orange.
E
Your starter kit packaging should be blue. - correct-answer - A
This medication can cause serious skin reactions, including a very severe rash.
B
It is important that this medication is titrated slowly; follow the instructions
carefully.
D
Your starter kit packaging should be orange.
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By Day #2 of her visit, DB's oxygen saturation has gradually improved and her
physician has asked the pharmacist to convert her SoluMedrol to an equivalent
dose of oral prednisone. What is the equivalent daily dose of oral prednisone in
milligrams? (Answer must be numeric; no units or commas; round the final
answer to the nearest WHOLE number.)
Solumedrol IV 20mg q8h - correct-answer - 75 mg prednisone daily
4 methylprednisolone: 5 prednisone: 5 prednisolone: 20 hydrocortisone
Which of the following statements concerning sumatriptan is correct?
Answer
A
It is contraindicated in patients with uncontrolled hypertension.
B
It is available as a needle-free intramuscular injection.
NORTH AMERICAN PHARMACIST LICENSURE
EXAMINATION
(NAPLEX) PRACTICE QUESTIONS WITH
VERIFIED ANSWERS 2026
A young adult female patient was prescribed an appropriate dose of Tylenol #3
during an emergency department visit. Within 48 hours, the patient was brought
back to the emergency department by ambulance due to respiratory depression
and somnolence. Which of the following is the most likely cause of this response?
Answer
A
The patient is HLA-B*5701 positive.
B
The patient has 2C192 or 3 alleles.
C
The patient is a 2D6 ultra-rapid metabolizer.
,2|Page
D
The patient has a deficiency of thiopurine methyltransferase (TPMT).
E
The patient has 2C92 or 3 alleles. - correct-answer - C
The patient is a 2D6 ultra-rapid metabolizer.
A pharmacist will counsel a female patient who is beginning lamotrigine therapy
for bipolar disorder. There are no interacting medications on the profile. Which of
the following counseling statements should the pharmacist share with the
patient? (Select ALL that apply.)
Answer
A
This medication can cause serious skin reactions, including a very severe rash.
B
It is important that this medication is titrated slowly; follow the instructions
carefully.
,3|Page
C
One of the brand names for this medication is Trileptal.
D
Your starter kit packaging should be orange.
E
Your starter kit packaging should be blue. - correct-answer - A
This medication can cause serious skin reactions, including a very severe rash.
B
It is important that this medication is titrated slowly; follow the instructions
carefully.
D
Your starter kit packaging should be orange.
, 4|Page
By Day #2 of her visit, DB's oxygen saturation has gradually improved and her
physician has asked the pharmacist to convert her SoluMedrol to an equivalent
dose of oral prednisone. What is the equivalent daily dose of oral prednisone in
milligrams? (Answer must be numeric; no units or commas; round the final
answer to the nearest WHOLE number.)
Solumedrol IV 20mg q8h - correct-answer - 75 mg prednisone daily
4 methylprednisolone: 5 prednisone: 5 prednisolone: 20 hydrocortisone
Which of the following statements concerning sumatriptan is correct?
Answer
A
It is contraindicated in patients with uncontrolled hypertension.
B
It is available as a needle-free intramuscular injection.
