CHT Practice Exam (ClinImmune Labs CHT/CHS Practice Exam) questions and
answers 2026\2027 A+ Grade
Which of the following is not a secondary lymphoid organ?
a. Spleen
b. Thymus
c. Lymph nodes
d. Liver
e. Tonsils
- correct answer b. Thymus
Which of the following is not a component of the reticuloendothelial cell system?
a. Microglial cells
b. Kupffer cells
c. Langerhans cells
d. Neutrophils
e. Monocytes
- correct answer d. Neutrophils (E. Monocytes, possibly)
Opsonization is a term to describe what?
a. Lysis of bacteria
b. Coating of bacteria
c. Ingestion of bacteria
d. Killing of bacteria
,e. Phagocytosis
- correct answer b. Coating of bacteria
Which of the following does not describe a role of antibodies in host defense?
a. They serve as a bridge between bacteria and phagocytes
b. They lyse bacteria
c. They enhance complement binding to the bacterial cell wall
d. They prevent viruses from infecting cells
e. They bind pathogens in mucus secretions
- correct answer b. They lyse bacteria
MHC Class I and II molecules differ in all of the following except
a. Types of T cells they stimulate
b. Types of cells they are expressed on
c. Which chromosome they are located on
d. Types of antigens they present
e. Whether or not they have foreign peptides in the antigen-binding groove
- correct answer c. Which chromosome they are located on
The primary role of the proteasome in antigen presentation is to
a. Prevent premature folding of MHC class I molecules
b. Process cytoplasmic proteins
c. Degrade recycled MHC molecules
d. Bind HLA-DM in the endosome
e. Chaperone peptides to the cell surface
- correct answer b. Process cytoplasmic proteins
,Peptides that bind to MHC class I molecules differ from peptides that bind to MHC class II molecules in
all except which of the following ways?
a. They are shorter
b. They were processed by different proteases
c. They anchor in the middle instead of the end of the MHC molecule
d. They interact with different subsets of T cells
- correct answer c. They anchor in the middle instead of the end of the MHC molecule
HLA-DM is primarily involved in the
a. Activation of cytotoxic T cells
b. Loading antigen onto HLA-DR molecules
c. Preventing HLA-A molecules from folding prior to antigen binding
d. Rejection of islet grafts
e. Induction of diabetes mellitus
- correct answer b. Loading antigen onto HLA-DR molecules
The antigen-binding site of an antibody is comprised of which of the following?
a. The variable region of the light and heavy chains
b. The variable region of the light chain only
c. The entire light chain
d. The entire heavy chain
e. The Fc portion of the immunoglobulin molecule
- correct answer a. The variable region of the light and heavy chains
10. The immunoglobulin that binds the most complement is
a. IgA
, b. IgD
c. IgM
d. IgG2
e. IgE
- correct answer c. IgM
11. The immunoglobulin responsible for activating mast cells in an allergic response is
a. IgA
b. IgD
c. IgM
d. IgG
e. IgE
- correct answer e. IgE
The molecular interaction between an antibody and its corresponding antigen is mediated by all except
which of the following?
a. Hydrogen bonds
b. Hydrophobic interactions
c. Covalent bonds
d. Electrostatic interactions
e. Van der Waals interactions..
- correct answer c. Covalent bonds
The phenomenon of 'affinity maturation,' in which later antibodies bind to antigen with a higher affinity
than the ones made weeks earlier, is due to
a. Allelic exclusion
b. VDJ recombination
answers 2026\2027 A+ Grade
Which of the following is not a secondary lymphoid organ?
a. Spleen
b. Thymus
c. Lymph nodes
d. Liver
e. Tonsils
- correct answer b. Thymus
Which of the following is not a component of the reticuloendothelial cell system?
a. Microglial cells
b. Kupffer cells
c. Langerhans cells
d. Neutrophils
e. Monocytes
- correct answer d. Neutrophils (E. Monocytes, possibly)
Opsonization is a term to describe what?
a. Lysis of bacteria
b. Coating of bacteria
c. Ingestion of bacteria
d. Killing of bacteria
,e. Phagocytosis
- correct answer b. Coating of bacteria
Which of the following does not describe a role of antibodies in host defense?
a. They serve as a bridge between bacteria and phagocytes
b. They lyse bacteria
c. They enhance complement binding to the bacterial cell wall
d. They prevent viruses from infecting cells
e. They bind pathogens in mucus secretions
- correct answer b. They lyse bacteria
MHC Class I and II molecules differ in all of the following except
a. Types of T cells they stimulate
b. Types of cells they are expressed on
c. Which chromosome they are located on
d. Types of antigens they present
e. Whether or not they have foreign peptides in the antigen-binding groove
- correct answer c. Which chromosome they are located on
The primary role of the proteasome in antigen presentation is to
a. Prevent premature folding of MHC class I molecules
b. Process cytoplasmic proteins
c. Degrade recycled MHC molecules
d. Bind HLA-DM in the endosome
e. Chaperone peptides to the cell surface
- correct answer b. Process cytoplasmic proteins
,Peptides that bind to MHC class I molecules differ from peptides that bind to MHC class II molecules in
all except which of the following ways?
a. They are shorter
b. They were processed by different proteases
c. They anchor in the middle instead of the end of the MHC molecule
d. They interact with different subsets of T cells
- correct answer c. They anchor in the middle instead of the end of the MHC molecule
HLA-DM is primarily involved in the
a. Activation of cytotoxic T cells
b. Loading antigen onto HLA-DR molecules
c. Preventing HLA-A molecules from folding prior to antigen binding
d. Rejection of islet grafts
e. Induction of diabetes mellitus
- correct answer b. Loading antigen onto HLA-DR molecules
The antigen-binding site of an antibody is comprised of which of the following?
a. The variable region of the light and heavy chains
b. The variable region of the light chain only
c. The entire light chain
d. The entire heavy chain
e. The Fc portion of the immunoglobulin molecule
- correct answer a. The variable region of the light and heavy chains
10. The immunoglobulin that binds the most complement is
a. IgA
, b. IgD
c. IgM
d. IgG2
e. IgE
- correct answer c. IgM
11. The immunoglobulin responsible for activating mast cells in an allergic response is
a. IgA
b. IgD
c. IgM
d. IgG
e. IgE
- correct answer e. IgE
The molecular interaction between an antibody and its corresponding antigen is mediated by all except
which of the following?
a. Hydrogen bonds
b. Hydrophobic interactions
c. Covalent bonds
d. Electrostatic interactions
e. Van der Waals interactions..
- correct answer c. Covalent bonds
The phenomenon of 'affinity maturation,' in which later antibodies bind to antigen with a higher affinity
than the ones made weeks earlier, is due to
a. Allelic exclusion
b. VDJ recombination
