Katzung Chapter 1: Nature of Drugs
and Chapter 2: Drug Receptors and
Pharmocodynamics
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, Pharmacology The study of substances that interact with living systems through chemical
processes by binding to regulatory molecules and activating or inhibiting normal
body activities used to treat, prevent or diagnose disease
Toxicology The undesirable effects of chemicals on living systems
Pharmacogenomics The relation of the individual's genetic makeup to his or her response to specific
drugs
Knocked out Mutated gene product is absent or nonfunctional.
Knockdown Limited suppression of a gene's function
Knockin Overexpression of a gene
Small interfering RNAs Small segments of RNA can interfere with protein synthesis with extreme
selectivity
Antisense oligonucleotides Complementary RNA or DNA can interfere with the transcription of RNA
Agonist Activate effector molecules or inhibit molecules responsible for terminating the
action of endogenous agonists
Antagonist Blocks binding of other molecules to a receptor
Partial agonist Partially activate effector molecules
Inverse agonist Stabilizes the receptor in the inactive form and prevents constitutive activity
Allosteric agents Bind to the receptor and enhance or inhibit receptor function but do not prevent
binding of the agonist
Xenobiotics Molecules not synthesized within the body
Toxins Poison of biological origin
Chirality Molecule that has non-superposable mirror image, often because of a
asymmetric carbon atom