Galen Pharmacology
Exam 1
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, What is Pharmacokinetics what the body does to the drug
What is Pharmacodynamics what the drug does to the body
What phase is Pharmacokinetics Absorption phase
Where does absorption of a drug take place Small intestine
What affects absorption time -Pill type
-stomach contents
-blood circulation
-pain, stress, anxiety
-route of administration
Contraindicators for medications Grapefruit juice and antacids
what is disintegration breakdown of oral drug into smaller particles
What is dissolution Process of combining small drug particles with liquid to form a solution
What is drug absorption Drug movement from GI tract into bloodstream
happens in small intestine
What is bioavailability What is left of drug after swallowing.
PO meds will never have 100% bioavailability
Factors affecting Bioavailability -Absorption
-first pass metabolism
-Drug form
-route of admin
-gastric mucous % motility
-changes in liver metabolism
-Administration w/ food and other drugs
What is first pass effect drugs absorbed from the GI tract enter the portal vein and pass through the liver
before entering circulation.
PO meds only
Characteristics of ADHD Inattentiveness, inability to concentrate, restlessness, hyperactivity, inability to
complete tasks, impulsivity
Characteristics of narcolepsy recurrent attacks of drowsiness and sleep during daytime
unable to control sleep
falling asleep while driving, talking, eating, standing
Where does drug metablosim occur In the the liver