Choline + Acetyl-CoA
CHT
v
↓ ChAT
E
Choline Ach
Car
It
Osc
cate
vesicles
2
i
a
tuxin (BotOx) YUMAP
Botulinum
↳ Inhibit
exocytosis
ofAch
m )
#
(Ach-relaxatiGN
on
.
↳ Indication Ach Ach
Direct-acting anticholinesterase
line
frown laxis
migraine prophy
+
S
+
SMame)
bladder
-
It
Ach Ach drugs "indirect
-
+ OAB GI sphincter Sweat)
S
"
of lower > N↓ acting
para
Spasm
-
+ My
(block ↑ Ach
paraly sis) Ach
Hyperhydrosis(systemic
Choline
Esterase
m . +
cause
Sympa
+ -
locally months
inject M M
/
: 3-4
↳ Note last j
Effect
mAchR nAchR ↑
Why muscle paralysis happen ?
AchE
Ap
h⑭
channel >
↓ of UG Nat
-
binds to
NM >
-
trigger depolarization -
ML
I
Frimempe
muscarinT
-
activated it's stuck here
-
i
+
closed - open
↑ ---------
(Para + Sympa Repolarization
preganglionic) I sustained
but depolarization is
-
> paralysis due to can't
repolarization that not close to stimulate m .
contraction
again
Succinykchelm m
-
.
>
-
depolarization blockade
CHT
v
↓ ChAT
E
Choline Ach
Car
It
Osc
cate
vesicles
2
i
a
tuxin (BotOx) YUMAP
Botulinum
↳ Inhibit
exocytosis
ofAch
m )
#
(Ach-relaxatiGN
on
.
↳ Indication Ach Ach
Direct-acting anticholinesterase
line
frown laxis
migraine prophy
+
S
+
SMame)
bladder
-
It
Ach Ach drugs "indirect
-
+ OAB GI sphincter Sweat)
S
"
of lower > N↓ acting
para
Spasm
-
+ My
(block ↑ Ach
paraly sis) Ach
Hyperhydrosis(systemic
Choline
Esterase
m . +
cause
Sympa
+ -
locally months
inject M M
/
: 3-4
↳ Note last j
Effect
mAchR nAchR ↑
Why muscle paralysis happen ?
AchE
Ap
h⑭
channel >
↓ of UG Nat
-
binds to
NM >
-
trigger depolarization -
ML
I
Frimempe
muscarinT
-
activated it's stuck here
-
i
+
closed - open
↑ ---------
(Para + Sympa Repolarization
preganglionic) I sustained
but depolarization is
-
> paralysis due to can't
repolarization that not close to stimulate m .
contraction
again
Succinykchelm m
-
.
>
-
depolarization blockade
