NURS 751 Finals Prep Questions and Answers |
2026 Update | 100% Correct.
Clinical Significance of Resilience
Lowers risk of:
Depression
Anxiety
PTSD
o Moderates response to treatment
Definition of Resilience
Capacity to effectively cope with and respond to stress
Neurobiological, Cognitive and Behavioral features of Resilience
o Intact reward and motivation systems
o Appropriate fear responses
o Adaptive social behaviors (altruism, social bonding)
o Accurate threat appraisal
o Avoids overly negative or overly positive biases
First-line agent for PTSD
SSRIs are first-line for PTSD
o Sertraline (Zoloft) carries an FDA indication for PTSD
Treatment for Sleep Disturbances associated with PTSD
,Temazepam (benzodiazepine) GAGBA-A agonist. may be used for short-term for sleep
disruption
• Trazodone (α1 antagonist) may also help with PTSD-related insomnia (off-label)
• Prazosin (minipress) (α1 antagonist) is especially helpful for nightmares in veterans
Dosing protocol for prazosin
o Start: 1 mg at bedtime for ≥3 nights
o Titrate: 3-15 mg (mean dose ~10 mg)
Improves sleep latency and duration
What is used for adrenergic modulation in PTSD?
Propranolol (beta blocker)
What to know about Propanolol for PTSD?
Beta Blocker
may prevent PTSD if given early
o Crosses blood-brain barrier → blunts adrenergic overconsolidation of trauma
memory
o Most effective if initiated within 6-24 hours of trauma
o Typical dose: 40 mg TID to QID for 7-10 days
NNT- 6-8. (experimental)
NNH- 50+ (bradycardia, fatigue)
, What is used to treat hyperarousal in PTSD?
Clonidine and Guanfacine
o Avoid abrupt withdrawal → rebound hypertension (especially with clonidine)
• Clonidine: binds to α2A, α2B, α2C → more sedating
(reduces hyperarousal and sympathetic tone)
• Guanfacine: more selective for α2A → less sedation (improves sleep and emotional regulation)
Study based dosing recommendations for Hydrocortisone in treating PTSD
100 mg hydrocortisone IV TID for 5 days post-op
100-140 mg/day hydrocortisone for 10 days post-trauma
A single 100 mg IV dose of hydrocortisone administered within 6 hours of
trauma was associated with reduced intrusive memories and lower CAPS scores at 1
month.
20-30 mg PO BID x 10 days starting within 12 hours of trauma reduced
PTSD symptoms and decreased emotional memory consolidation.
what to know about hydrocortisone for PTSD
2026 Update | 100% Correct.
Clinical Significance of Resilience
Lowers risk of:
Depression
Anxiety
PTSD
o Moderates response to treatment
Definition of Resilience
Capacity to effectively cope with and respond to stress
Neurobiological, Cognitive and Behavioral features of Resilience
o Intact reward and motivation systems
o Appropriate fear responses
o Adaptive social behaviors (altruism, social bonding)
o Accurate threat appraisal
o Avoids overly negative or overly positive biases
First-line agent for PTSD
SSRIs are first-line for PTSD
o Sertraline (Zoloft) carries an FDA indication for PTSD
Treatment for Sleep Disturbances associated with PTSD
,Temazepam (benzodiazepine) GAGBA-A agonist. may be used for short-term for sleep
disruption
• Trazodone (α1 antagonist) may also help with PTSD-related insomnia (off-label)
• Prazosin (minipress) (α1 antagonist) is especially helpful for nightmares in veterans
Dosing protocol for prazosin
o Start: 1 mg at bedtime for ≥3 nights
o Titrate: 3-15 mg (mean dose ~10 mg)
Improves sleep latency and duration
What is used for adrenergic modulation in PTSD?
Propranolol (beta blocker)
What to know about Propanolol for PTSD?
Beta Blocker
may prevent PTSD if given early
o Crosses blood-brain barrier → blunts adrenergic overconsolidation of trauma
memory
o Most effective if initiated within 6-24 hours of trauma
o Typical dose: 40 mg TID to QID for 7-10 days
NNT- 6-8. (experimental)
NNH- 50+ (bradycardia, fatigue)
, What is used to treat hyperarousal in PTSD?
Clonidine and Guanfacine
o Avoid abrupt withdrawal → rebound hypertension (especially with clonidine)
• Clonidine: binds to α2A, α2B, α2C → more sedating
(reduces hyperarousal and sympathetic tone)
• Guanfacine: more selective for α2A → less sedation (improves sleep and emotional regulation)
Study based dosing recommendations for Hydrocortisone in treating PTSD
100 mg hydrocortisone IV TID for 5 days post-op
100-140 mg/day hydrocortisone for 10 days post-trauma
A single 100 mg IV dose of hydrocortisone administered within 6 hours of
trauma was associated with reduced intrusive memories and lower CAPS scores at 1
month.
20-30 mg PO BID x 10 days starting within 12 hours of trauma reduced
PTSD symptoms and decreased emotional memory consolidation.
what to know about hydrocortisone for PTSD
