CPHON CORRECT FINAL EXAM QUESTIONS AND
ANSWERS SURE A+
✔✔Cisplatin - ✔✔-Alkylating agent
-Delayed n/v (severe)
-Mannitol (to ensure adequate urinary output)
*May also see renal damage and hemorrhagic cystitis*
-hypomagnesemia (need mag supplementation)
-Ototoxicity
-Antidote is sodium thiosulfate
✔✔Dactinomycin - ✔✔-Anthracycline
-Radiation recall (an acute inflammatory reaction confined to previously irradiated areas
that can be triggered when chemotherapy agents are administered after radiotherapy)
✔✔Daunorubicin/doxorubicin - ✔✔Anthracyclines
Monitor cardiac function
✔✔Irinotecan - ✔✔-Plant derivative
-Diarrhea
✔✔MTX - ✔✔-Anti-metabolite
-Avoid vitamins containing folic acid
-Can cause long term cognitive impairment
✔✔Thiotepa - ✔✔-Alkylating agent
-Excreted through skin (importance of skin care)
✔✔__________ is fatal if given IT! - ✔✔Vincristine
✔✔Vincristine - ✔✔-Plant derivative
-Fatal if given IT
-Neuropathy
, -Max dose is 2mg
✔✔5 plant derivative chemotherapeutic agents - ✔✔1. Vincristine
2. Paclitaxel
3. Etoposide
4. Topotecan
5. Irinotecan
✔✔What are seen in the cytoplasm of AML blasts? - ✔✔*Auer Rods*
✔✔Treatment of APML (acute promyelocytic leukemia) - ✔✔Retinoic acid + lower
doses of chemo
✔✔Chloroma - ✔✔A malignant, green-colored tumor of myeloid cells
✔✔_______ is the single best predictor of favorable outcomes for AML. - ✔✔Trisomy 21
✔✔TLS is more common with ALL than AML. What other cancers do you commonly
see it in? Lab Findings? Tx? - ✔✔Common in high-grade non-Hodgkin lymphoma, ALL,
& Burkitt's lymphoma.
Hyperkalemia, hyperuricemia, hyperphosphatemia
IVF, sodium bicarb to increase urine pH. Allopurinol.
✔✔What 3 anti-microbials are commonly implicated in anaphylaxis? - ✔✔1. Bactrim
2. Penicillin
3. Amphotericin B
✔✔In setting of pediatric oncology, what is the most common cause of DIC? - ✔✔Gram
negative sepsis
✔✔Hyperleukocytosis is defined as WBC count >100,000 but children are not typically
symptomatic until count surpasses >_______. - ✔✔300,000/mm3 (100 for AML)
*Most common with CML, AML, and ALL.
Oncologic emergency because blood viscosity may be increased and white cell
aggregates can occlude vessels in the microcirculation. Tx includes aggressive
hydration (2-4x MIVF), sodium bicarb to correct acidosis, TLS drugs, chemo,
leukapheresis.
*Marianne says this is wrong!
✔✔Treatment for increased ICP - ✔✔Dexamethasone
ANSWERS SURE A+
✔✔Cisplatin - ✔✔-Alkylating agent
-Delayed n/v (severe)
-Mannitol (to ensure adequate urinary output)
*May also see renal damage and hemorrhagic cystitis*
-hypomagnesemia (need mag supplementation)
-Ototoxicity
-Antidote is sodium thiosulfate
✔✔Dactinomycin - ✔✔-Anthracycline
-Radiation recall (an acute inflammatory reaction confined to previously irradiated areas
that can be triggered when chemotherapy agents are administered after radiotherapy)
✔✔Daunorubicin/doxorubicin - ✔✔Anthracyclines
Monitor cardiac function
✔✔Irinotecan - ✔✔-Plant derivative
-Diarrhea
✔✔MTX - ✔✔-Anti-metabolite
-Avoid vitamins containing folic acid
-Can cause long term cognitive impairment
✔✔Thiotepa - ✔✔-Alkylating agent
-Excreted through skin (importance of skin care)
✔✔__________ is fatal if given IT! - ✔✔Vincristine
✔✔Vincristine - ✔✔-Plant derivative
-Fatal if given IT
-Neuropathy
, -Max dose is 2mg
✔✔5 plant derivative chemotherapeutic agents - ✔✔1. Vincristine
2. Paclitaxel
3. Etoposide
4. Topotecan
5. Irinotecan
✔✔What are seen in the cytoplasm of AML blasts? - ✔✔*Auer Rods*
✔✔Treatment of APML (acute promyelocytic leukemia) - ✔✔Retinoic acid + lower
doses of chemo
✔✔Chloroma - ✔✔A malignant, green-colored tumor of myeloid cells
✔✔_______ is the single best predictor of favorable outcomes for AML. - ✔✔Trisomy 21
✔✔TLS is more common with ALL than AML. What other cancers do you commonly
see it in? Lab Findings? Tx? - ✔✔Common in high-grade non-Hodgkin lymphoma, ALL,
& Burkitt's lymphoma.
Hyperkalemia, hyperuricemia, hyperphosphatemia
IVF, sodium bicarb to increase urine pH. Allopurinol.
✔✔What 3 anti-microbials are commonly implicated in anaphylaxis? - ✔✔1. Bactrim
2. Penicillin
3. Amphotericin B
✔✔In setting of pediatric oncology, what is the most common cause of DIC? - ✔✔Gram
negative sepsis
✔✔Hyperleukocytosis is defined as WBC count >100,000 but children are not typically
symptomatic until count surpasses >_______. - ✔✔300,000/mm3 (100 for AML)
*Most common with CML, AML, and ALL.
Oncologic emergency because blood viscosity may be increased and white cell
aggregates can occlude vessels in the microcirculation. Tx includes aggressive
hydration (2-4x MIVF), sodium bicarb to correct acidosis, TLS drugs, chemo,
leukapheresis.
*Marianne says this is wrong!
✔✔Treatment for increased ICP - ✔✔Dexamethasone
