NUR 3145 Pharmacology Exam 3
Questions With Correct Answers
Parkinson's Disease Medications - CORRECT ANSWER✔✔-Mechanism of
| | | | | |
action: increase levels of dopamine and/or antagonize effects of Ach
| | | | | | | | | |
Indirect acting dopaminergic drugs - CORRECT ANSWER✔✔-selegiline
| | | | | | |
(Zelapar) -indirect acting dopamine receptor agonists (MAO-B inhibitor);
| | | | | | |
|inhibits the action of the enzyme monoamine oxidase; primary role of
| | | | | | | | | | |
MAO is the breakdown of catecholamines; prevents breakdown of
| | | | | | | | |
lepadopa
used in early stage ; adjunct drug.
| | | | | | |
Adverse effect: interaction with tyramine foods;(cheese; wine, beer ,
| | | | | | | | |
yogurt) produces severe hypertension
| | |
MAO (monoamine oxidase) causes - CORRECT ANSWER✔✔-the
| | | | | | |
breakdown of catecholamines in the body; the catecholamines are epi;
| | | | | | | | | |
norepi; and dopamine.
| |
MAO inhibitors ; selegiline and rasagiline causes an increase in the levels
| | | | | | | | | | |
of dopaminergic stimulation in the CNS; both are approved for use in
| | | | | | | | | | | | |
combo with carbidopa-levodopa; do not use concurrently with
| | | | | | | |
meperidine
,Dopamine Modulator: - CORRECT ANSWER✔✔-amantadine
| | | | |
(Symmetrel) - anti viral used in the early stage; nerve fibers release
| | | | | | | | | | | |
dopamine in the basal ganglia & blocks the reuptake of dopamine
| | | | | | | | | | |
reduces tremor and rigidity; also used for influenza; effective for 6-8
| | | | | | | | | | |
months. |
Adverse effects: dizziness, insomnia and nausea; this med has
| | | | | | | | |
anticholinergic effects, if used with other anticholinergic meds will have
| | | | | | | | | |
additive effects |
COMT Inhibitor: both drugs block COMT - CORRECT ANSWER✔✔-
| | | | | | | |
talcapone (Tasmar)- adjunct drug to carbidopa-levodopa; treats
| | | | | | |
symptoms; levodopa dose-sparing effect. Works both centrally and
| | | | | | | |
peripherally
entacapone (Comtan) - adjunct; Works only peripherally, can not cross
| | | | | | | | | |
BBB
Adverse effect: GI upset, urine discoloration; associated with severe
| | | | | | | | |
liver failure.
|
Direct acting dopamine receptor agonist
| | | |
first line agents; stimulate pre/post synaptic dopamine receptors in the
| | | | | | | | | |
brain stimulate production of more dopamine; all dopamine agonists -
| | | | | | | | | |
CORRECT ANSWER✔✔- |
, direct acting dopamine receptor agonists (drugs) - CORRECT
| | | | | | | |
ANSWER✔✔-bromocriptine (Parlodel)..Adverse effects: ataxia, | | | |
dizziness, headache, depression, Caution: can produce vasoconstriction
| | | | | | |
in peripheral tissues; can worsen PVD
| | | | |
Pramipexole (Mirapex)..Adverse Effects: edema, fatigue, syncope,
| | | | | |
dizziness, drowsiness |
Ropinirole (Requip)..Adverse effects: drowsiness; ortho hypotension
| | | | |
Dopamine replacement drugs: - CORRECT ANSWER✔✔-carbidopa-
| | | | |
levodopa (Sinemet) - drug of choice for elderly patients; used when
| | | | | | | | | | |
patient functionally impaired. Carbidopa prevents breakdown in
| | | | | | |
periphery and thus prevents s/s of too much levodopa and also requires
| | | | | | | | | | |
|lesser dose of levodopa
| | |
Large doses of levodopa:
| | |
involuntary movements, GI distress, hypotension and cardiac
| | | | | | |
arrhythmias
Adverse effects: palpitations, hypotension, urinary retention,
| | | | | |
depression, dyskinesia |
parkinsons adjunct meds Anti-cholinergic Drugs - CORRECT
| | | | | | |
ANSWER✔✔-Cogentin (benztropine): secondary drug for | | | |
Questions With Correct Answers
Parkinson's Disease Medications - CORRECT ANSWER✔✔-Mechanism of
| | | | | |
action: increase levels of dopamine and/or antagonize effects of Ach
| | | | | | | | | |
Indirect acting dopaminergic drugs - CORRECT ANSWER✔✔-selegiline
| | | | | | |
(Zelapar) -indirect acting dopamine receptor agonists (MAO-B inhibitor);
| | | | | | |
|inhibits the action of the enzyme monoamine oxidase; primary role of
| | | | | | | | | | |
MAO is the breakdown of catecholamines; prevents breakdown of
| | | | | | | | |
lepadopa
used in early stage ; adjunct drug.
| | | | | | |
Adverse effect: interaction with tyramine foods;(cheese; wine, beer ,
| | | | | | | | |
yogurt) produces severe hypertension
| | |
MAO (monoamine oxidase) causes - CORRECT ANSWER✔✔-the
| | | | | | |
breakdown of catecholamines in the body; the catecholamines are epi;
| | | | | | | | | |
norepi; and dopamine.
| |
MAO inhibitors ; selegiline and rasagiline causes an increase in the levels
| | | | | | | | | | |
of dopaminergic stimulation in the CNS; both are approved for use in
| | | | | | | | | | | | |
combo with carbidopa-levodopa; do not use concurrently with
| | | | | | | |
meperidine
,Dopamine Modulator: - CORRECT ANSWER✔✔-amantadine
| | | | |
(Symmetrel) - anti viral used in the early stage; nerve fibers release
| | | | | | | | | | | |
dopamine in the basal ganglia & blocks the reuptake of dopamine
| | | | | | | | | | |
reduces tremor and rigidity; also used for influenza; effective for 6-8
| | | | | | | | | | |
months. |
Adverse effects: dizziness, insomnia and nausea; this med has
| | | | | | | | |
anticholinergic effects, if used with other anticholinergic meds will have
| | | | | | | | | |
additive effects |
COMT Inhibitor: both drugs block COMT - CORRECT ANSWER✔✔-
| | | | | | | |
talcapone (Tasmar)- adjunct drug to carbidopa-levodopa; treats
| | | | | | |
symptoms; levodopa dose-sparing effect. Works both centrally and
| | | | | | | |
peripherally
entacapone (Comtan) - adjunct; Works only peripherally, can not cross
| | | | | | | | | |
BBB
Adverse effect: GI upset, urine discoloration; associated with severe
| | | | | | | | |
liver failure.
|
Direct acting dopamine receptor agonist
| | | |
first line agents; stimulate pre/post synaptic dopamine receptors in the
| | | | | | | | | |
brain stimulate production of more dopamine; all dopamine agonists -
| | | | | | | | | |
CORRECT ANSWER✔✔- |
, direct acting dopamine receptor agonists (drugs) - CORRECT
| | | | | | | |
ANSWER✔✔-bromocriptine (Parlodel)..Adverse effects: ataxia, | | | |
dizziness, headache, depression, Caution: can produce vasoconstriction
| | | | | | |
in peripheral tissues; can worsen PVD
| | | | |
Pramipexole (Mirapex)..Adverse Effects: edema, fatigue, syncope,
| | | | | |
dizziness, drowsiness |
Ropinirole (Requip)..Adverse effects: drowsiness; ortho hypotension
| | | | |
Dopamine replacement drugs: - CORRECT ANSWER✔✔-carbidopa-
| | | | |
levodopa (Sinemet) - drug of choice for elderly patients; used when
| | | | | | | | | | |
patient functionally impaired. Carbidopa prevents breakdown in
| | | | | | |
periphery and thus prevents s/s of too much levodopa and also requires
| | | | | | | | | | |
|lesser dose of levodopa
| | |
Large doses of levodopa:
| | |
involuntary movements, GI distress, hypotension and cardiac
| | | | | | |
arrhythmias
Adverse effects: palpitations, hypotension, urinary retention,
| | | | | |
depression, dyskinesia |
parkinsons adjunct meds Anti-cholinergic Drugs - CORRECT
| | | | | | |
ANSWER✔✔-Cogentin (benztropine): secondary drug for | | | |
