Week 1 Exam: NR565 / NR 565
(Latest ) Advanced
Pharmacology Fundamentals |
Questions & Answers | 100%
Correct | Grade A - Chamberlain
Question:
FDA & QT Interval Drugs
Answer:
· QT interval drugs refers to ability of some drugs to prolong QT interval on
electrocardiogram. Creates risk of dysrhythmias.
o QT interval:
§ Measure of time required for ventricles to repolarize after each
contraction
o Can lead to torsades de pointes which can lead to VFIB
· FDA requires all new drugs to be tested for ability to cause QT
prolongation
,Question:
Boxed Warnings
Answer:
· AKA black box warning - presented on inside of prescription box with
heavy black border
· Strongest safety warning drug can carry and still be on the market
· FDA required - Alert for potentially life-threatening side effects and how
to reduce and prevent harm
· Box warning must appear on an advertising, package insert and product
label
Examples:
· Promethazine (Phenergan) - can cause resp distress in <2 y/o or tissue
necrosis if injected
· Teratogenic drugs
, Question:
Identifying Adverse Drug Reactions
Answer:
· Any noxious or unintended or undesired effect that occurs with normal
drug doses.
· Ex: Allergy, side effect, toxicity, idiosyncratic effect, paradoxical effect,
iatrogenic disease, physical dependence, carcinogenic effect, teratogenic
effect
· Can be difficult to determine. Consider following questions:
o Did symptoms appear shortly after drug was first used?
o Did symptoms abate when drug was discontinued?
o Did symptoms reappear when drug was restarted?
o Is the illness itself sufficient to explain the event?
o Are other drugs in regimen sufficient to explain the event
Question:
Metabolic influences on drug administration
Answer:
· Age: Immature or degenerated organs (liver disease) cannot metabolize
drug quick enough, accumulation occurs. Prolong therapeutic effects,
increased risk toxicity
· In liver disease, drugs eliminated through hepatic metabolization must be
reduced or discontinued
(Latest ) Advanced
Pharmacology Fundamentals |
Questions & Answers | 100%
Correct | Grade A - Chamberlain
Question:
FDA & QT Interval Drugs
Answer:
· QT interval drugs refers to ability of some drugs to prolong QT interval on
electrocardiogram. Creates risk of dysrhythmias.
o QT interval:
§ Measure of time required for ventricles to repolarize after each
contraction
o Can lead to torsades de pointes which can lead to VFIB
· FDA requires all new drugs to be tested for ability to cause QT
prolongation
,Question:
Boxed Warnings
Answer:
· AKA black box warning - presented on inside of prescription box with
heavy black border
· Strongest safety warning drug can carry and still be on the market
· FDA required - Alert for potentially life-threatening side effects and how
to reduce and prevent harm
· Box warning must appear on an advertising, package insert and product
label
Examples:
· Promethazine (Phenergan) - can cause resp distress in <2 y/o or tissue
necrosis if injected
· Teratogenic drugs
, Question:
Identifying Adverse Drug Reactions
Answer:
· Any noxious or unintended or undesired effect that occurs with normal
drug doses.
· Ex: Allergy, side effect, toxicity, idiosyncratic effect, paradoxical effect,
iatrogenic disease, physical dependence, carcinogenic effect, teratogenic
effect
· Can be difficult to determine. Consider following questions:
o Did symptoms appear shortly after drug was first used?
o Did symptoms abate when drug was discontinued?
o Did symptoms reappear when drug was restarted?
o Is the illness itself sufficient to explain the event?
o Are other drugs in regimen sufficient to explain the event
Question:
Metabolic influences on drug administration
Answer:
· Age: Immature or degenerated organs (liver disease) cannot metabolize
drug quick enough, accumulation occurs. Prolong therapeutic effects,
increased risk toxicity
· In liver disease, drugs eliminated through hepatic metabolization must be
reduced or discontinued
