ATI Pharmacology
Thrombolytic Drugs Latest
Practice Questions And
Correct Answers (Verified
Answers) Plus Rationales 2026
Q&A | Instant Download Pdf
1. A patient is prescribed alteplase. What is the primary
therapeutic effect?
A. Prevent platelet aggregation
B. Dissolve existing clots
C. Increase blood viscosity
D. Reduce blood pressure
Answer: B. Dissolve existing clots
Rationale: Alteplase is a thrombolytic that breaks down fibrin
and dissolves formed clots.
2. Which condition is a contraindication for thrombolytic
therapy?
A. Ischemic stroke within 3 hours
B. Active internal bleeding
C. Myocardial infarction
,D. Deep vein thrombosis
Answer: B. Active internal bleeding
Rationale: Thrombolytics increase bleeding risk and are
contraindicated in active bleeding.
3. What is the priority nursing assessment before
administering thrombolytics?
A. Lung sounds
B. Bowel sounds
C. Bleeding history
D. Pupillary response
Answer: C. Bleeding history
Rationale: A history of bleeding disorders increases risk of
hemorrhage.
4. Which medication is a tissue plasminogen activator
(tPA)?
A. Heparin
B. Warfarin
C. Alteplase
D. Aspirin
Answer: C. Alteplase
Rationale: Alteplase is a recombinant tPA.
5. A major adverse effect of thrombolytics is:
,A. Hypertension
B. Hemorrhage
C. Bradycardia
D. Hypoglycemia
Answer: B. Hemorrhage
Rationale: Bleeding is the most serious complication.
6. Which lab value should be monitored during
thrombolytic therapy?
A. INR
B. Hemoglobin and hematocrit
C. Sodium level
D. Calcium level
Answer: B. Hemoglobin and hematocrit
Rationale: Decreasing levels may indicate internal bleeding.
7. Streptokinase works by:
A. Blocking thrombin
B. Activating plasminogen
C. Inhibiting vitamin K
D. Increasing clot formation
Answer: B. Activating plasminogen
Rationale: It converts plasminogen to plasmin to dissolve
clots.
, 8. After thrombolytic administration, the nurse should
monitor for:
A. Fever and chills
B. Signs of bleeding
C. Hyperglycemia
D. Constipation
Answer: B. Signs of bleeding
Rationale: Bleeding is the most life-threatening complication.
9. Which drug is commonly used in acute myocardial
infarction?
A. Alteplase
B. Atropine
C. Dopamine
D. Furosemide
Answer: A. Alteplase
Rationale: tPA is used to restore coronary blood flow.
10. Which finding requires immediate intervention after
thrombolytic therapy?
A. Bruising at IV site
B. Sudden headache
C. Mild nausea
D. Low-grade fever
Answer: B. Sudden headache
Rationale: May indicate intracranial hemorrhage.
Thrombolytic Drugs Latest
Practice Questions And
Correct Answers (Verified
Answers) Plus Rationales 2026
Q&A | Instant Download Pdf
1. A patient is prescribed alteplase. What is the primary
therapeutic effect?
A. Prevent platelet aggregation
B. Dissolve existing clots
C. Increase blood viscosity
D. Reduce blood pressure
Answer: B. Dissolve existing clots
Rationale: Alteplase is a thrombolytic that breaks down fibrin
and dissolves formed clots.
2. Which condition is a contraindication for thrombolytic
therapy?
A. Ischemic stroke within 3 hours
B. Active internal bleeding
C. Myocardial infarction
,D. Deep vein thrombosis
Answer: B. Active internal bleeding
Rationale: Thrombolytics increase bleeding risk and are
contraindicated in active bleeding.
3. What is the priority nursing assessment before
administering thrombolytics?
A. Lung sounds
B. Bowel sounds
C. Bleeding history
D. Pupillary response
Answer: C. Bleeding history
Rationale: A history of bleeding disorders increases risk of
hemorrhage.
4. Which medication is a tissue plasminogen activator
(tPA)?
A. Heparin
B. Warfarin
C. Alteplase
D. Aspirin
Answer: C. Alteplase
Rationale: Alteplase is a recombinant tPA.
5. A major adverse effect of thrombolytics is:
,A. Hypertension
B. Hemorrhage
C. Bradycardia
D. Hypoglycemia
Answer: B. Hemorrhage
Rationale: Bleeding is the most serious complication.
6. Which lab value should be monitored during
thrombolytic therapy?
A. INR
B. Hemoglobin and hematocrit
C. Sodium level
D. Calcium level
Answer: B. Hemoglobin and hematocrit
Rationale: Decreasing levels may indicate internal bleeding.
7. Streptokinase works by:
A. Blocking thrombin
B. Activating plasminogen
C. Inhibiting vitamin K
D. Increasing clot formation
Answer: B. Activating plasminogen
Rationale: It converts plasminogen to plasmin to dissolve
clots.
, 8. After thrombolytic administration, the nurse should
monitor for:
A. Fever and chills
B. Signs of bleeding
C. Hyperglycemia
D. Constipation
Answer: B. Signs of bleeding
Rationale: Bleeding is the most life-threatening complication.
9. Which drug is commonly used in acute myocardial
infarction?
A. Alteplase
B. Atropine
C. Dopamine
D. Furosemide
Answer: A. Alteplase
Rationale: tPA is used to restore coronary blood flow.
10. Which finding requires immediate intervention after
thrombolytic therapy?
A. Bruising at IV site
B. Sudden headache
C. Mild nausea
D. Low-grade fever
Answer: B. Sudden headache
Rationale: May indicate intracranial hemorrhage.
