KATZUNG'S BASIC AND
CLINICAL PHARMACOLOGY
16TH EDITION
• AUTHOR(S)TODD W.
VANDERAH
TEST BANK
,Question 1
A nurse is reviewing the concept of drug selectivity. Which
statement best describes a selective drug?
A. It produces identical effects in all body systems
B. It targets a specific receptor at therapeutic doses
C. It has no adverse effects when administered correctly
D. It is effective regardless of dosage
Correct Answer: B
Rationale:
A selective drug primarily interacts with a specific receptor or
tissue at therapeutic doses, minimizing effects on other
systems. Option A is incorrect because no drug produces
identical effects in all systems. Option C is incorrect since all
drugs have the potential for adverse effects. Option D is
incorrect because drug effects are dose-dependent.
Question 2
A nurse is explaining pharmacokinetics to a patient. Which
process involves the movement of a drug from the bloodstream
into body tissues?
A. Absorption
,B. Distribution
C. Metabolism
D. Excretion
Correct Answer: B
Rationale:
Distribution refers to the transport of a drug from the
bloodstream to tissues and organs. Absorption (A) is the
movement of a drug into the bloodstream. Metabolism (C)
involves chemical alteration, primarily in the liver. Excretion (D)
is the removal of drugs from the body.
Question 3
A nurse administers an oral medication that undergoes
significant first-pass metabolism. What is the expected effect?
A. Increased bioavailability
B. Decreased drug concentration before reaching systemic
circulation
C. Immediate therapeutic effect
D. Prolonged half-life
Correct Answer: B
Rationale:
, First-pass metabolism reduces the amount of active drug
reaching systemic circulation by metabolizing it in the liver.
Option A is incorrect because bioavailability decreases. Option C
is incorrect because oral drugs typically have delayed onset.
Option D is unrelated to first-pass metabolism.
Question 4
A patient is prescribed a medication with a narrow therapeutic
index. What is the nurse’s priority action?
A. Administer the drug with food
B. Monitor drug levels closely
C. Double the dose if a dose is missed
D. Avoid patient education to prevent confusion
Correct Answer: B
Rationale:
Drugs with a narrow therapeutic index require careful
monitoring of plasma levels to avoid toxicity or subtherapeutic
dosing. Option A may or may not be relevant. Option C is
unsafe. Option D is incorrect because education is essential.
Question 5
A nurse notes that a drug is highly protein-bound. What
implication does this have?
CLINICAL PHARMACOLOGY
16TH EDITION
• AUTHOR(S)TODD W.
VANDERAH
TEST BANK
,Question 1
A nurse is reviewing the concept of drug selectivity. Which
statement best describes a selective drug?
A. It produces identical effects in all body systems
B. It targets a specific receptor at therapeutic doses
C. It has no adverse effects when administered correctly
D. It is effective regardless of dosage
Correct Answer: B
Rationale:
A selective drug primarily interacts with a specific receptor or
tissue at therapeutic doses, minimizing effects on other
systems. Option A is incorrect because no drug produces
identical effects in all systems. Option C is incorrect since all
drugs have the potential for adverse effects. Option D is
incorrect because drug effects are dose-dependent.
Question 2
A nurse is explaining pharmacokinetics to a patient. Which
process involves the movement of a drug from the bloodstream
into body tissues?
A. Absorption
,B. Distribution
C. Metabolism
D. Excretion
Correct Answer: B
Rationale:
Distribution refers to the transport of a drug from the
bloodstream to tissues and organs. Absorption (A) is the
movement of a drug into the bloodstream. Metabolism (C)
involves chemical alteration, primarily in the liver. Excretion (D)
is the removal of drugs from the body.
Question 3
A nurse administers an oral medication that undergoes
significant first-pass metabolism. What is the expected effect?
A. Increased bioavailability
B. Decreased drug concentration before reaching systemic
circulation
C. Immediate therapeutic effect
D. Prolonged half-life
Correct Answer: B
Rationale:
, First-pass metabolism reduces the amount of active drug
reaching systemic circulation by metabolizing it in the liver.
Option A is incorrect because bioavailability decreases. Option C
is incorrect because oral drugs typically have delayed onset.
Option D is unrelated to first-pass metabolism.
Question 4
A patient is prescribed a medication with a narrow therapeutic
index. What is the nurse’s priority action?
A. Administer the drug with food
B. Monitor drug levels closely
C. Double the dose if a dose is missed
D. Avoid patient education to prevent confusion
Correct Answer: B
Rationale:
Drugs with a narrow therapeutic index require careful
monitoring of plasma levels to avoid toxicity or subtherapeutic
dosing. Option A may or may not be relevant. Option C is
unsafe. Option D is incorrect because education is essential.
Question 5
A nurse notes that a drug is highly protein-bound. What
implication does this have?
