KATZUNG'S BASIC AND
CLINICAL PHARMACOLOGY
16TH EDITION
• AUTHOR(S)TODD W.
VANDERAH
TEST BANK
,Question 1
A nurse is reviewing a medication order for a newly approved
prescription drug. Which statement best explains why post-
marketing surveillance remains necessary after the drug has
been approved for clinical use?
A. It determines the exact dose required for every patient.
B. It identifies rare or delayed adverse effects that may not have
appeared during preapproval studies.
C. It replaces the need for preclinical laboratory testing.
D. It guarantees that the medication is superior to all existing
therapies.
Correct Answer: B
Rationale:
Post-marketing surveillance continues after approval to detect
uncommon, long-term, or delayed adverse effects that may not
have been identified during clinical trials because of limited
sample sizes and study durations. Option A is incorrect because
individual dosing still depends on patient-specific factors.
Option C is incorrect because preclinical testing remains an
essential step before human studies. Option D is incorrect
because approval demonstrates that benefits outweigh risks for
approved indications, not that the drug is better than every
alternative.
,Question 2
A nurse is preparing to administer a medication that has a
narrow therapeutic index. Which nursing action is the highest
priority?
A. Administer the medication with food regardless of
instructions.
B. Monitor prescribed laboratory values and assess for signs of
toxicity.
C. Double the next dose if a scheduled dose is missed.
D. Discontinue the medication after symptom improvement.
Correct Answer: B
Rationale:
Drugs with a narrow therapeutic index require close monitoring
because small changes in drug concentration may result in
toxicity or treatment failure. Laboratory monitoring and careful
assessment improve patient safety. Option A may alter drug
absorption and should only be done if indicated. Option C
increases the risk of toxicity. Option D may lead to disease
recurrence or treatment failure.
Question 3
, A patient asks why a medication underwent years of testing
before becoming available. Which response by the nurse is
most appropriate?
A. "The testing helps evaluate safety, effectiveness, and
appropriate dosing before widespread use."
B. "Testing mainly determines the medication's retail price."
C. "Testing guarantees the medication has no adverse effects."
D. "Testing is performed only after the medication is marketed."
Correct Answer: A
Rationale:
Drug development includes extensive testing to evaluate safety,
efficacy, dosing, and potential adverse effects before regulatory
approval. Option B is unrelated to the purpose of drug
development. Option C is incorrect because no medication is
completely free of risk. Option D reverses the sequence of drug
development.
Question 4
A nurse is teaching a patient about reporting medication side
effects. Which statement by the patient indicates correct
understanding?
A. "I should report unexpected symptoms even if they are not
listed in the medication guide."
CLINICAL PHARMACOLOGY
16TH EDITION
• AUTHOR(S)TODD W.
VANDERAH
TEST BANK
,Question 1
A nurse is reviewing a medication order for a newly approved
prescription drug. Which statement best explains why post-
marketing surveillance remains necessary after the drug has
been approved for clinical use?
A. It determines the exact dose required for every patient.
B. It identifies rare or delayed adverse effects that may not have
appeared during preapproval studies.
C. It replaces the need for preclinical laboratory testing.
D. It guarantees that the medication is superior to all existing
therapies.
Correct Answer: B
Rationale:
Post-marketing surveillance continues after approval to detect
uncommon, long-term, or delayed adverse effects that may not
have been identified during clinical trials because of limited
sample sizes and study durations. Option A is incorrect because
individual dosing still depends on patient-specific factors.
Option C is incorrect because preclinical testing remains an
essential step before human studies. Option D is incorrect
because approval demonstrates that benefits outweigh risks for
approved indications, not that the drug is better than every
alternative.
,Question 2
A nurse is preparing to administer a medication that has a
narrow therapeutic index. Which nursing action is the highest
priority?
A. Administer the medication with food regardless of
instructions.
B. Monitor prescribed laboratory values and assess for signs of
toxicity.
C. Double the next dose if a scheduled dose is missed.
D. Discontinue the medication after symptom improvement.
Correct Answer: B
Rationale:
Drugs with a narrow therapeutic index require close monitoring
because small changes in drug concentration may result in
toxicity or treatment failure. Laboratory monitoring and careful
assessment improve patient safety. Option A may alter drug
absorption and should only be done if indicated. Option C
increases the risk of toxicity. Option D may lead to disease
recurrence or treatment failure.
Question 3
, A patient asks why a medication underwent years of testing
before becoming available. Which response by the nurse is
most appropriate?
A. "The testing helps evaluate safety, effectiveness, and
appropriate dosing before widespread use."
B. "Testing mainly determines the medication's retail price."
C. "Testing guarantees the medication has no adverse effects."
D. "Testing is performed only after the medication is marketed."
Correct Answer: A
Rationale:
Drug development includes extensive testing to evaluate safety,
efficacy, dosing, and potential adverse effects before regulatory
approval. Option B is unrelated to the purpose of drug
development. Option C is incorrect because no medication is
completely free of risk. Option D reverses the sequence of drug
development.
Question 4
A nurse is teaching a patient about reporting medication side
effects. Which statement by the patient indicates correct
understanding?
A. "I should report unexpected symptoms even if they are not
listed in the medication guide."
