WGU D115 OA ADVANCED
PATHOPHYSIOLOGY 2026 PATHOPHYSIOLOGY
CONCEPTS AND CLINICAL APPLICATION
REVIEW GUIDE
◉ Which of the following is a hallmark clinical sign of Nephrotic
Syndrome?
A) Massive proteinuria (>3.5g/day)
B) Hematuria
C) Hypotension
D) Hypolipidemia.
Answer: A
◉ The most common causative organism in uncomplicated UTIs is:
A) Staphylococcus aureus
B) Klebsiella pneumoniae
C) Proteus mirabilis
D) Escherichia coli.
Answer: D
◉ Which hypersensitivity reaction is involved in Anaphylaxis?
,A) Type II (Cytotoxic)
B) Type III (Immune complex)
C) Type I (IgE-mediated)
D) Type IV (Delayed-type).
Answer: C
◉ The pathophysiological hallmark of SLE is:
A) Destruction of T-cells
B) Deposition of immune complexes
C) Excessive production of IgE
D) Mast cell degranulation.
Answer: B
◉ In Iron Deficiency Anemia.
Answer: how does the MCV appear?
A) Microcytic (Low MCV)
B) Macrocytic (High MCV)
C) Normocytic (Normal MCV)
D) Hyperchromic, A
◉ Which physical finding is specific to Vitamin B12 deficiency but
NOT folate?
, A) Fatigue
B) Glossitis
C) Pallor
D) Paresthesia and neurological deficits.
Answer: D
◉ What is the primary defect in Hemophilia A?
A) Deficiency of Factor IX
B) Platelet dysfunction
C) Deficiency of Factor VIII
D) Vitamin K deficiency.
Answer: C
◉ A "shift to the left" on a CBC with differential indicates:
A) Viral infection
B) Parasitic infestation
C) Chronic macrocytic anemia
D) Increased immature neutrophils (bands).
Answer: D
◉ What is the main physiological role of Hemoglobin A1c?
A) Reflecting average blood glucose over 2-3 months
PATHOPHYSIOLOGY 2026 PATHOPHYSIOLOGY
CONCEPTS AND CLINICAL APPLICATION
REVIEW GUIDE
◉ Which of the following is a hallmark clinical sign of Nephrotic
Syndrome?
A) Massive proteinuria (>3.5g/day)
B) Hematuria
C) Hypotension
D) Hypolipidemia.
Answer: A
◉ The most common causative organism in uncomplicated UTIs is:
A) Staphylococcus aureus
B) Klebsiella pneumoniae
C) Proteus mirabilis
D) Escherichia coli.
Answer: D
◉ Which hypersensitivity reaction is involved in Anaphylaxis?
,A) Type II (Cytotoxic)
B) Type III (Immune complex)
C) Type I (IgE-mediated)
D) Type IV (Delayed-type).
Answer: C
◉ The pathophysiological hallmark of SLE is:
A) Destruction of T-cells
B) Deposition of immune complexes
C) Excessive production of IgE
D) Mast cell degranulation.
Answer: B
◉ In Iron Deficiency Anemia.
Answer: how does the MCV appear?
A) Microcytic (Low MCV)
B) Macrocytic (High MCV)
C) Normocytic (Normal MCV)
D) Hyperchromic, A
◉ Which physical finding is specific to Vitamin B12 deficiency but
NOT folate?
, A) Fatigue
B) Glossitis
C) Pallor
D) Paresthesia and neurological deficits.
Answer: D
◉ What is the primary defect in Hemophilia A?
A) Deficiency of Factor IX
B) Platelet dysfunction
C) Deficiency of Factor VIII
D) Vitamin K deficiency.
Answer: C
◉ A "shift to the left" on a CBC with differential indicates:
A) Viral infection
B) Parasitic infestation
C) Chronic macrocytic anemia
D) Increased immature neutrophils (bands).
Answer: D
◉ What is the main physiological role of Hemoglobin A1c?
A) Reflecting average blood glucose over 2-3 months
