ATI PN PHARMACOLOGY PROCTORED EXAM
350 2026 SOLVED QUESTIONS ANSWERS
GRADED A PLUS PHARMACOKINETICS AND
PHARMACODYNAMICS HANDBOOK
◉ NSAIDS (Ibuprofen).
Answer: Analgesic, anti-inflammatory, antipyretic, antiprostaglandin
Sodium based = may increase BP/heart failure, causes Ulcers
SE = N/V, GI bleeding, heartburn, epigastric pain, GI ulcer, renal
impairment, bruising, blood in urine
Caution = with MI's and bypass patient's.
No more than 3,200 Mg/day (it can kill the kidneys/especially
w/long term use)
Nursing interventions = check GFR, platelets, bleeding times, liver
enzymes.
◉ Aspirin (ASA).
Answer: Non-opioid
non-steroidal
anti-inflammatory
,antipyretic
Blood thinner
Aspirin = binds to Cox 1/Cox 2 (stops platelet aggregation, gi upset,
tinnitus, HA, sweating)
◉ Aspirin (ASA).
Answer: Increased risk for GI bleeding (coffee ground emesis, black
tarry stool)
Increase Prothrombin time (PT/INR) ...stop a week before surgery
due to platelet life of 7 days
Enteric coated = prevent GI bleed/upset
Toxicity = tinnitus, humming, dizzy, bad balance, nausea
Caution = with heparin, lovenox, coumadin, Nsaids
◉ Tylenol (acetaminophen).
Answer: Acetaminophen (Tylenol/APAP)
Antipyretic/analgesic-Centrally acting Cox Inhibitor
Acts on hypothalamus--->dilates peripheral blood vessels
No Anti-inflammatory Property/Enhances opioids for pain relief
Hepatotoxic ....NO MORE THAN 4 GRAMS/DAILY
Side Effects:
Renal/Hepatic failure, N/V, Chills, abd. discomfort, Inhibits warfarin
metabolism (can cause it to accumulate)
,Acetylcystiene/Mucomyst---antidote for Tylenol OD
Baby Drops(babies)
Liquids (children)
◉ Tylenol.
Answer: Anti-pyretic--Analgesis---Centrally acting Cox Inhibitor
Acts on Hypothalamus --> dilates peripheral blood vessels
No inflammatory property
◉ PCA pumps.
Answer: 4 hour dose limit
Set machine for how many mg/hour.
Encourage = use before activities
Assess client = LOC, RR, BP, HR
Educate = it's very hard to OD on pumps
Nursing Intervention = check IV line patency, ask to change PCA to
oral med if they're feeling better
Nursing Prejudices = assess their pain, respirations must be 12+
Pain 1-4 = PO meds
Pain 5-10 = IV meds
◉ Narcan (naloxone).
, Answer: Opioid antagonist
Treats Overdose = competes w/opioid receptors
Don't give with pregnancy
(Rebound resp depression, abstinence syndrome, titrate dosage,
rapid infusion)
IV, IM, SQ, NOT ORALLY
1/2 LIFE = 60-90 MINUTES
1/2 LIFE = 3-4 hours
Can lead to rebound respiratory depression
Respirations = Monitor for 4 hours after giving it
◉ Narcan.
Answer: SE = tachycardia, tachypnea, ventricula arrhythmia,
pulmonary edema
Abstinence syndrome = cramping, HTN, vomiting (by stopping
morphine effect, we can induce withdrawal quickly)
Caution = history of heart failure/pulm edema (the
HTN/teachycardia can induce heart failure by increasing workload
of the heart)
Contraindicated = with opioid dependency (immediate withdrawal)
Titrate dosage = relieve pain, reverse respiratory depression (if you
don't titrate it can cause sudden onset of pain/withdrawal)
Rapid Infusion = HTN, tachycardia, N/V
350 2026 SOLVED QUESTIONS ANSWERS
GRADED A PLUS PHARMACOKINETICS AND
PHARMACODYNAMICS HANDBOOK
◉ NSAIDS (Ibuprofen).
Answer: Analgesic, anti-inflammatory, antipyretic, antiprostaglandin
Sodium based = may increase BP/heart failure, causes Ulcers
SE = N/V, GI bleeding, heartburn, epigastric pain, GI ulcer, renal
impairment, bruising, blood in urine
Caution = with MI's and bypass patient's.
No more than 3,200 Mg/day (it can kill the kidneys/especially
w/long term use)
Nursing interventions = check GFR, platelets, bleeding times, liver
enzymes.
◉ Aspirin (ASA).
Answer: Non-opioid
non-steroidal
anti-inflammatory
,antipyretic
Blood thinner
Aspirin = binds to Cox 1/Cox 2 (stops platelet aggregation, gi upset,
tinnitus, HA, sweating)
◉ Aspirin (ASA).
Answer: Increased risk for GI bleeding (coffee ground emesis, black
tarry stool)
Increase Prothrombin time (PT/INR) ...stop a week before surgery
due to platelet life of 7 days
Enteric coated = prevent GI bleed/upset
Toxicity = tinnitus, humming, dizzy, bad balance, nausea
Caution = with heparin, lovenox, coumadin, Nsaids
◉ Tylenol (acetaminophen).
Answer: Acetaminophen (Tylenol/APAP)
Antipyretic/analgesic-Centrally acting Cox Inhibitor
Acts on hypothalamus--->dilates peripheral blood vessels
No Anti-inflammatory Property/Enhances opioids for pain relief
Hepatotoxic ....NO MORE THAN 4 GRAMS/DAILY
Side Effects:
Renal/Hepatic failure, N/V, Chills, abd. discomfort, Inhibits warfarin
metabolism (can cause it to accumulate)
,Acetylcystiene/Mucomyst---antidote for Tylenol OD
Baby Drops(babies)
Liquids (children)
◉ Tylenol.
Answer: Anti-pyretic--Analgesis---Centrally acting Cox Inhibitor
Acts on Hypothalamus --> dilates peripheral blood vessels
No inflammatory property
◉ PCA pumps.
Answer: 4 hour dose limit
Set machine for how many mg/hour.
Encourage = use before activities
Assess client = LOC, RR, BP, HR
Educate = it's very hard to OD on pumps
Nursing Intervention = check IV line patency, ask to change PCA to
oral med if they're feeling better
Nursing Prejudices = assess their pain, respirations must be 12+
Pain 1-4 = PO meds
Pain 5-10 = IV meds
◉ Narcan (naloxone).
, Answer: Opioid antagonist
Treats Overdose = competes w/opioid receptors
Don't give with pregnancy
(Rebound resp depression, abstinence syndrome, titrate dosage,
rapid infusion)
IV, IM, SQ, NOT ORALLY
1/2 LIFE = 60-90 MINUTES
1/2 LIFE = 3-4 hours
Can lead to rebound respiratory depression
Respirations = Monitor for 4 hours after giving it
◉ Narcan.
Answer: SE = tachycardia, tachypnea, ventricula arrhythmia,
pulmonary edema
Abstinence syndrome = cramping, HTN, vomiting (by stopping
morphine effect, we can induce withdrawal quickly)
Caution = history of heart failure/pulm edema (the
HTN/teachycardia can induce heart failure by increasing workload
of the heart)
Contraindicated = with opioid dependency (immediate withdrawal)
Titrate dosage = relieve pain, reverse respiratory depression (if you
don't titrate it can cause sudden onset of pain/withdrawal)
Rapid Infusion = HTN, tachycardia, N/V
