UNDERSTANDING PATHOPHYSIOLOGY
HUETHER AND McCANCE FULL REVISION
NOTES WITH CELLULAR INJURY AND
ADAPTATION CONCEPTS
◉ 4 forces that determine if filtration or reabsorption occurs.
Answer: 1- capillary hydrostatic pressure
2-capillary oncotic pressure
3-Interstitial hydrostatic pressure
4-Interstitial oncotic pressure
◉ capillary hydrostatic pressure.
Answer: the outward movement of water from the capillary to the
interstitial place (being pushed out)
◉ capillary oncotic pressure.
Answer: osmotically attracts water from the interstitial space back
into the capillary (pulls)
◉ Interstitial hydrostatic pressure.
Answer: facilitates the inward movement of water from the
interstitial space into the capillary (pushes)
,◉ interstitial oncotic pressure.
Answer: osmotically attracts water from the capillary into the
interstitial space (pulls)
◉ Aquaporins.
Answer: a family of water channel proteins that provide
permeability to water
how water moves freely by diffusion through the lipid bilayer cell
membrane
◉ Edema.
Answer: excessive accumulation of fluid within the interstitial
spaces
◉ Thrombophelebitis.
Answer: inflammation of veins
◉ Common causes of venous obstruction.
Answer: Thrombophelebitis
hepatic obstruction
, tight clothing around extremities
prolonged standing
◉ Lymphedema.
Answer: when lymphatic channels are blocked or surgically removed
causes proteins and fluid accumulate in the interstitial space
◉ Localized Edema.
Answer: usually limited to site of trauma, as in sprained finger
another type occurs when particular organ systems including
cerebral, pulmonary, and laryngeal ; pleaural effusion; pericardial
effusion; ascites
life-threatening if includes brain, lung, larynx
◉ Pleural Effusion.
Answer: fluid accumulation in pleural spaces
◉ Pericardial Effusion.
HUETHER AND McCANCE FULL REVISION
NOTES WITH CELLULAR INJURY AND
ADAPTATION CONCEPTS
◉ 4 forces that determine if filtration or reabsorption occurs.
Answer: 1- capillary hydrostatic pressure
2-capillary oncotic pressure
3-Interstitial hydrostatic pressure
4-Interstitial oncotic pressure
◉ capillary hydrostatic pressure.
Answer: the outward movement of water from the capillary to the
interstitial place (being pushed out)
◉ capillary oncotic pressure.
Answer: osmotically attracts water from the interstitial space back
into the capillary (pulls)
◉ Interstitial hydrostatic pressure.
Answer: facilitates the inward movement of water from the
interstitial space into the capillary (pushes)
,◉ interstitial oncotic pressure.
Answer: osmotically attracts water from the capillary into the
interstitial space (pulls)
◉ Aquaporins.
Answer: a family of water channel proteins that provide
permeability to water
how water moves freely by diffusion through the lipid bilayer cell
membrane
◉ Edema.
Answer: excessive accumulation of fluid within the interstitial
spaces
◉ Thrombophelebitis.
Answer: inflammation of veins
◉ Common causes of venous obstruction.
Answer: Thrombophelebitis
hepatic obstruction
, tight clothing around extremities
prolonged standing
◉ Lymphedema.
Answer: when lymphatic channels are blocked or surgically removed
causes proteins and fluid accumulate in the interstitial space
◉ Localized Edema.
Answer: usually limited to site of trauma, as in sprained finger
another type occurs when particular organ systems including
cerebral, pulmonary, and laryngeal ; pleaural effusion; pericardial
effusion; ascites
life-threatening if includes brain, lung, larynx
◉ Pleural Effusion.
Answer: fluid accumulation in pleural spaces
◉ Pericardial Effusion.
