KATZUNG'S BASIC AND
CLINICAL PHARMACOLOGY
16TH EDITION
• AUTHOR(S)TODD W.
VANDERAH
TEST BANK
,Question 1
A nurse is teaching a community group about the process used
before a new medication becomes widely available. Which
statement by a participant indicates correct understanding?
A. "A medication is approved after it has shown acceptable
safety and effectiveness in clinical studies."
B. "A medication can be marketed as soon as laboratory testing
is complete."
C. "All adverse effects are known before a medication is
approved."
D. "Once approved, a medication no longer requires safety
monitoring."
Correct Answer: A
Rationale:
Clinical studies are conducted to evaluate whether a medication
demonstrates an acceptable balance of safety and effectiveness
before regulatory approval. Laboratory and animal studies
alone are insufficient for approval. Rare or long-term adverse
effects may not become apparent until after widespread use,
making continued post-marketing surveillance essential.
Question 2
,A nurse is reviewing a newly prescribed medication. Which
characteristic best describes a drug with high therapeutic
selectivity?
A. It produces the desired effect with minimal action on
unintended tissues.
B. It always has a rapid onset of action.
C. It never produces adverse reactions.
D. It requires only one lifetime dose.
Correct Answer: A
Rationale:
Selective drugs preferentially act on intended receptors or
tissues, reducing unwanted effects. Selectivity is not absolute,
and adverse reactions may still occur, particularly at higher
doses. Onset of action and dosing frequency are unrelated to
selectivity.
Question 3
A patient asks why two medications with different brand names
contain the same active ingredient. What is the nurse's best
response?
A. "Different manufacturers may market the same generic
medication under different brand names."
, B. "Brand-name medications always contain different active
ingredients."
C. "Generic medications are less effective than brand-name
medications."
D. "Brand names identify the medication's pharmacologic
class."
Correct Answer: A
Rationale:
Multiple manufacturers may produce medications containing
the same active ingredient while using different brand names.
Approved generic medications are expected to meet standards
for quality and therapeutic equivalence. Brand names identify
products rather than pharmacologic classes.
Question 4
A nurse administers an antihypertensive medication. Which
event best represents a pharmacodynamic effect?
A. The medication lowers the patient's blood pressure.
B. The medication is absorbed through the gastrointestinal
tract.
C. The medication is metabolized by the liver.
D. The medication is eliminated by the kidneys.
CLINICAL PHARMACOLOGY
16TH EDITION
• AUTHOR(S)TODD W.
VANDERAH
TEST BANK
,Question 1
A nurse is teaching a community group about the process used
before a new medication becomes widely available. Which
statement by a participant indicates correct understanding?
A. "A medication is approved after it has shown acceptable
safety and effectiveness in clinical studies."
B. "A medication can be marketed as soon as laboratory testing
is complete."
C. "All adverse effects are known before a medication is
approved."
D. "Once approved, a medication no longer requires safety
monitoring."
Correct Answer: A
Rationale:
Clinical studies are conducted to evaluate whether a medication
demonstrates an acceptable balance of safety and effectiveness
before regulatory approval. Laboratory and animal studies
alone are insufficient for approval. Rare or long-term adverse
effects may not become apparent until after widespread use,
making continued post-marketing surveillance essential.
Question 2
,A nurse is reviewing a newly prescribed medication. Which
characteristic best describes a drug with high therapeutic
selectivity?
A. It produces the desired effect with minimal action on
unintended tissues.
B. It always has a rapid onset of action.
C. It never produces adverse reactions.
D. It requires only one lifetime dose.
Correct Answer: A
Rationale:
Selective drugs preferentially act on intended receptors or
tissues, reducing unwanted effects. Selectivity is not absolute,
and adverse reactions may still occur, particularly at higher
doses. Onset of action and dosing frequency are unrelated to
selectivity.
Question 3
A patient asks why two medications with different brand names
contain the same active ingredient. What is the nurse's best
response?
A. "Different manufacturers may market the same generic
medication under different brand names."
, B. "Brand-name medications always contain different active
ingredients."
C. "Generic medications are less effective than brand-name
medications."
D. "Brand names identify the medication's pharmacologic
class."
Correct Answer: A
Rationale:
Multiple manufacturers may produce medications containing
the same active ingredient while using different brand names.
Approved generic medications are expected to meet standards
for quality and therapeutic equivalence. Brand names identify
products rather than pharmacologic classes.
Question 4
A nurse administers an antihypertensive medication. Which
event best represents a pharmacodynamic effect?
A. The medication lowers the patient's blood pressure.
B. The medication is absorbed through the gastrointestinal
tract.
C. The medication is metabolized by the liver.
D. The medication is eliminated by the kidneys.
